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STRINGSTRING
EML5 EML5 XPA XPA ITFG2 ITFG2 PCDHA12 PCDHA12 ZNF518A ZNF518A GTF3C4 GTF3C4 CDCP2 CDCP2 ZNF717 ZNF717 SRRM3 SRRM3 C15orf57 C15orf57 GPATCH4 GPATCH4
"ZNF518A" - Zinc finger protein 518A in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
ZNF518AZinc finger protein 518A; May be involved in transcriptional regulation; Zinc fingers C2H2-type (1483 aa)    
Predicted Functional Partners:
CDCP2
CUB domain containing protein 2 (449 aa)
            
  0.630
C15orf57
Coiled-coil domain-containing protein 32; Chromosome 15 open reading frame 57 (194 aa)
            
  0.538
SRRM3
Serine/arginine repetitive matrix 3; Belongs to the CWC21 family (653 aa)
            
  0.525
XPA
DNA repair protein complementing XP-A cells; Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation; Belongs to the XPA family (273 aa)
        
      0.513
GPATCH4
G-patch domain containing 4 (375 aa)
            
  0.489
ITFG2
KICSTOR complex protein ITFG2; As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose (447 aa)
            
  0.473
EML5
Echinoderm microtubule-associated protein-like 5; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; WD repeat domain containing (1977 aa)
        
 
  0.471
PCDHA12
Protocadherin alpha-12; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins (941 aa)
        
 
  0.464
ZNF717
Zinc finger protein 717; Zinc fingers C2H2-type (110 aa)
            
  0.441
GTF3C4
General transcription factor 3C polypeptide 4; Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box; Belongs to the TFIIIC subunit 4 family (822 aa)
            
  0.422
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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