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STRINGSTRING
FAM222B FAM222B MTRNR2L12 MTRNR2L12 TRIM28 TRIM28 FAM135A FAM135A RNF144A RNF144A DEFB115 DEFB115 ZNF727P ZNF727P ASB7 ASB7 PRSS46 PRSS46 SEC14L6 SEC14L6 USP17L1P USP17L1P
"ZNF727P" - Putative zinc finger protein 727 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ZNF727PPutative zinc finger protein 727; May be involved in transcriptional regulation (499 aa)    
Predicted Functional Partners:
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
      
  0.904
DEFB115
Beta-defensin 115; Has antibacterial activity; Defensins, beta (88 aa)
            
  0.670
ASB7
Ankyrin repeat and SOCS box protein 7; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family (318 aa)
      
 
  0.600
FAM135A
Protein FAM135A; Family with sequence similarity 135 member A; Belongs to the FAM135 family (1515 aa)
            
  0.584
PRSS46
Protease, serine, 46; Belongs to the peptidase S1 family (174 aa)
            
  0.554
RNF144A
E3 ubiquitin-protein ligase RNF144A; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC (292 aa)
        
 
  0.515
SEC14L6
Putative SEC14-like protein 6; SEC14 like lipid binding 6 (397 aa)
      
 
  0.500
MTRNR2L12
Humanin-like 8; Plays a role as a neuroprotective and antiapoptotic factor; Belongs to the humanin family (24 aa)
            
  0.493
FAM222B
Protein FAM222B; Family with sequence similarity 222 member B (562 aa)
            
  0.491
USP17L1P
Ubiquitin carboxyl-terminal hydrolase 17-like protein 1; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection (530 aa)
            
  0.473
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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