UBTFL1 protein (human) - STRING database

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UBTFL1

Upstream-binding factor 1-like protein 1; Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development (393 aa)

Predicted Functional Partners:

BDP1

0.749

EMP2

0.655

ZSCAN4

0.628

CDX2

0.609

LEUTX

0.577

OR2T2

0.573

OR4C3

0.570

TRIM43

0.513

ZNF595

0.507

GTF2IRD1

0.493

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BDP1	UBTFL1	ENSP00000351575	ENSP00000485108	Transcription factor TFIIIB component B’’ homolog; General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site; Myb/SANT domain containing	Upstream-binding factor 1-like protein 1; Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development	0.749
CDX2	UBTFL1	ENSP00000370408	ENSP00000485108	Homeobox protein CDX-2; Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine; HOXL subclass homeoboxes	Upstream-binding factor 1-like protein 1; Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development	0.609
EMP2	UBTFL1	ENSP00000352540	ENSP00000485108	Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation. Facilitates surface trafficking and formation of lipid rafts bearing GPI-anchor proteins (By similarity). Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cyto [...]	Upstream-binding factor 1-like protein 1; Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development	0.655
GTF2IRD1	UBTFL1	ENSP00000397566	ENSP00000485108	General transcription factor II-I repeat domain-containing protein 1; May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity)	Upstream-binding factor 1-like protein 1; Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development	0.493
LEUTX	TRIM43	ENSP00000380053	ENSP00000272395	PRD class homeoboxes and pseudogenes	Tripartite motif containing 43; Ring finger proteins	0.528
LEUTX	UBTFL1	ENSP00000380053	ENSP00000485108	PRD class homeoboxes and pseudogenes	Upstream-binding factor 1-like protein 1; Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development	0.577
LEUTX	ZSCAN4	ENSP00000380053	ENSP00000321963	PRD class homeoboxes and pseudogenes	Zinc finger and SCAN domain-containing protein 4; Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity); SCAN domain containing	0.471
OR2T2	UBTFL1	ENSP00000343062	ENSP00000485108	Olfactory receptor 2T2; Odorant receptor; Olfactory receptors, family 2	Upstream-binding factor 1-like protein 1; Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development	0.573
OR2T2	ZNF595	ENSP00000343062	ENSP00000477392	Olfactory receptor 2T2; Odorant receptor; Olfactory receptors, family 2	Zinc finger protein 595; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.473
OR4C3	UBTFL1	ENSP00000321419	ENSP00000485108	Olfactory receptor 4C3; Odorant receptor; Olfactory receptors, family 4	Upstream-binding factor 1-like protein 1; Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development	0.570
OR4C3	ZNF595	ENSP00000321419	ENSP00000477392	Olfactory receptor 4C3; Odorant receptor; Olfactory receptors, family 4	Zinc finger protein 595; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.471
TRIM43	LEUTX	ENSP00000272395	ENSP00000380053	Tripartite motif containing 43; Ring finger proteins	PRD class homeoboxes and pseudogenes	0.528
TRIM43	UBTFL1	ENSP00000272395	ENSP00000485108	Tripartite motif containing 43; Ring finger proteins	Upstream-binding factor 1-like protein 1; Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development	0.513
TRIM43	ZSCAN4	ENSP00000272395	ENSP00000321963	Tripartite motif containing 43; Ring finger proteins	Zinc finger and SCAN domain-containing protein 4; Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity); SCAN domain containing	0.687
UBTFL1	BDP1	ENSP00000485108	ENSP00000351575	Upstream-binding factor 1-like protein 1; Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development	Transcription factor TFIIIB component B’’ homolog; General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site; Myb/SANT domain containing	0.749
UBTFL1	CDX2	ENSP00000485108	ENSP00000370408	Upstream-binding factor 1-like protein 1; Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development	Homeobox protein CDX-2; Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine; HOXL subclass homeoboxes	0.609
UBTFL1	EMP2	ENSP00000485108	ENSP00000352540	Upstream-binding factor 1-like protein 1; Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development	Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation. Facilitates surface trafficking and formation of lipid rafts bearing GPI-anchor proteins (By similarity). Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cyto [...]	0.655
UBTFL1	GTF2IRD1	ENSP00000485108	ENSP00000397566	Upstream-binding factor 1-like protein 1; Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development	General transcription factor II-I repeat domain-containing protein 1; May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity)	0.493
UBTFL1	LEUTX	ENSP00000485108	ENSP00000380053	Upstream-binding factor 1-like protein 1; Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development	PRD class homeoboxes and pseudogenes	0.577
UBTFL1	OR2T2	ENSP00000485108	ENSP00000343062	Upstream-binding factor 1-like protein 1; Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development	Olfactory receptor 2T2; Odorant receptor; Olfactory receptors, family 2	0.573

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