• Version:
  • 11.0 [archived version]
STRINGSTRING
DEFB128 DEFB128 DEFB121 DEFB121 DEFB113 DEFB113 DEFB116 DEFB116 DEFB115 DEFB115 DEFB133 DEFB133 DEFB112 DEFB112 DEFB114 DEFB114 DEFB127 DEFB127 DEFB135 DEFB135 DEFB110 DEFB110
"DEFB133" - Beta-defensin 133 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DEFB133Beta-defensin 133; Has antibacterial activity; Defensins, beta (61 aa)    
Predicted Functional Partners:
DEFB110
Beta-defensin 110; Has antibacterial activity; Defensins, beta (67 aa)
      
 
    0.910
DEFB135
Beta-defensin 135; Has antibacterial activity; Defensins, beta (77 aa)
      
 
    0.908
DEFB113
Beta-defensin 113; Has antibacterial activity; Defensins, beta (82 aa)
      
 
    0.907
DEFB121
Beta-defensin 121; Has antibacterial activity; Belongs to the beta-defensin family (76 aa)
      
 
    0.907
DEFB116
Beta-defensin 116; Has antibacterial activity; Defensins, beta (102 aa)
      
 
    0.906
DEFB115
Beta-defensin 115; Has antibacterial activity; Defensins, beta (88 aa)
      
 
    0.905
DEFB128
Beta-defensin 128; Has antibacterial activity; Defensins, beta (93 aa)
      
 
    0.905
DEFB114
Beta-defensin 114; Has a salt-sensitive antimicrobial activity against Gram-negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS- induced reduction of sperm motility in vitro and may protect from LPS-induced lethality; Defensins, beta (69 aa)
      
 
    0.905
DEFB127
Beta-defensin 127; Has antibacterial activity; Defensins, beta (99 aa)
      
 
    0.905
DEFB112
Beta-defensin 112; Has antibacterial activity; Defensins, beta (113 aa)
      
 
    0.904
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (0%) [HD]
STRING is part of the ELIXIR infrastructure: it is one of ELIXIR's Core Data Resources.  Learn more >