| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BLK | NKAPL | ENSP00000259089 | ENSP00000345716 | Tyrosine-protein kinase Blk; Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis d [...] | NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis | 0.405 |
| BLK | ZSCAN26 | ENSP00000259089 | ENSP00000484931 | Tyrosine-protein kinase Blk; Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis d [...] | Zinc finger and SCAN domain-containing protein 26; May be involved in transcriptional regulation; SCAN domain containing | 0.476 |
| CHD3 | KIZ | ENSP00000369716 | ENSP00000479542 | Chromodomain-helicase-DNA-binding protein 3; Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity; Belongs to the SNF2/RAD54 helicase family | Centrosomal protein kizuna; Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole; Belongs to the kizuna family | 0.508 |
| CHD3 | VSIG10L | ENSP00000369716 | ENSP00000335623 | Chromodomain-helicase-DNA-binding protein 3; Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity; Belongs to the SNF2/RAD54 helicase family | V-set and immunoglobulin domain containing 10 like | 0.497 |
| CHD3 | ZSCAN26 | ENSP00000369716 | ENSP00000484931 | Chromodomain-helicase-DNA-binding protein 3; Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity; Belongs to the SNF2/RAD54 helicase family | Zinc finger and SCAN domain-containing protein 26; May be involved in transcriptional regulation; SCAN domain containing | 0.548 |
| CPA5 | ZSCAN26 | ENSP00000420237 | ENSP00000484931 | M14 carboxypeptidases; Belongs to the peptidase M14 family | Zinc finger and SCAN domain-containing protein 26; May be involved in transcriptional regulation; SCAN domain containing | 0.509 |
| KIZ | CHD3 | ENSP00000479542 | ENSP00000369716 | Centrosomal protein kizuna; Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole; Belongs to the kizuna family | Chromodomain-helicase-DNA-binding protein 3; Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity; Belongs to the SNF2/RAD54 helicase family | 0.508 |
| KIZ | VSIG10L | ENSP00000479542 | ENSP00000335623 | Centrosomal protein kizuna; Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole; Belongs to the kizuna family | V-set and immunoglobulin domain containing 10 like | 0.672 |
| KIZ | ZSCAN26 | ENSP00000479542 | ENSP00000484931 | Centrosomal protein kizuna; Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole; Belongs to the kizuna family | Zinc finger and SCAN domain-containing protein 26; May be involved in transcriptional regulation; SCAN domain containing | 0.658 |
| NKAPL | BLK | ENSP00000345716 | ENSP00000259089 | NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis | Tyrosine-protein kinase Blk; Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis d [...] | 0.405 |
| NKAPL | PRKCQ | ENSP00000345716 | ENSP00000263125 | NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis | Protein kinase C theta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non- redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transact [...] | 0.511 |
| NKAPL | ZSCAN26 | ENSP00000345716 | ENSP00000484931 | NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis | Zinc finger and SCAN domain-containing protein 26; May be involved in transcriptional regulation; SCAN domain containing | 0.613 |
| NR1H2 | VSIG10L | ENSP00000253727 | ENSP00000335623 | Oxysterols receptor LXR-beta; Nuclear receptor. Binds preferentially to double- stranded oligonucleotide direct repeats having the consensus half- site sequence 5’-AGGTCA-3’ and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Exhibits a ligand-dependent transcriptional activation activity; Belongs to the nuclear hormone receptor family. NR1 subfamily | V-set and immunoglobulin domain containing 10 like | 0.443 |
| NR1H2 | ZSCAN26 | ENSP00000253727 | ENSP00000484931 | Oxysterols receptor LXR-beta; Nuclear receptor. Binds preferentially to double- stranded oligonucleotide direct repeats having the consensus half- site sequence 5’-AGGTCA-3’ and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Exhibits a ligand-dependent transcriptional activation activity; Belongs to the nuclear hormone receptor family. NR1 subfamily | Zinc finger and SCAN domain-containing protein 26; May be involved in transcriptional regulation; SCAN domain containing | 0.443 |
| PRKCQ | NKAPL | ENSP00000263125 | ENSP00000345716 | Protein kinase C theta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non- redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transact [...] | NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis | 0.511 |
| PRKCQ | ZSCAN26 | ENSP00000263125 | ENSP00000484931 | Protein kinase C theta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non- redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transact [...] | Zinc finger and SCAN domain-containing protein 26; May be involved in transcriptional regulation; SCAN domain containing | 0.526 |
| TMEM151A | ZSCAN26 | ENSP00000326244 | ENSP00000484931 | Transmembrane protein 151A | Zinc finger and SCAN domain-containing protein 26; May be involved in transcriptional regulation; SCAN domain containing | 0.442 |
| VSIG10L | CHD3 | ENSP00000335623 | ENSP00000369716 | V-set and immunoglobulin domain containing 10 like | Chromodomain-helicase-DNA-binding protein 3; Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity; Belongs to the SNF2/RAD54 helicase family | 0.497 |
| VSIG10L | KIZ | ENSP00000335623 | ENSP00000479542 | V-set and immunoglobulin domain containing 10 like | Centrosomal protein kizuna; Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole; Belongs to the kizuna family | 0.672 |
| VSIG10L | NR1H2 | ENSP00000335623 | ENSP00000253727 | V-set and immunoglobulin domain containing 10 like | Oxysterols receptor LXR-beta; Nuclear receptor. Binds preferentially to double- stranded oligonucleotide direct repeats having the consensus half- site sequence 5’-AGGTCA-3’ and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Exhibits a ligand-dependent transcriptional activation activity; Belongs to the nuclear hormone receptor family. NR1 subfamily | 0.443 |
