| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARMC1 | ARMC9 | ENSP00000276569 | ENSP00000484804 | Armadillo repeat containing 1 | LisH domain-containing protein ARMC9; Armadillo repeat containing 9 | 0.727 |
| ARMC1 | FBXO22 | ENSP00000276569 | ENSP00000307833 | Armadillo repeat containing 1 | F-box only protein 22; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function; F-boxes other | 0.740 |
| ARMC1 | GEMIN7 | ENSP00000276569 | ENSP00000270257 | Armadillo repeat containing 1 | Gem-associated protein 7; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chapero [...] | 0.699 |
| ARMC1 | RHBDD1 | ENSP00000276569 | ENSP00000375914 | Armadillo repeat containing 1 | Rhomboid-related protein 4; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfe [...] | 0.747 |
| ARMC1 | SIVA1 | ENSP00000276569 | ENSP00000329213 | Armadillo repeat containing 1 | Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa- B and promotes T-cell receptor-mediated apoptosis | 0.632 |
| ARMC1 | SNAPC5 | ENSP00000276569 | ENSP00000319597 | Armadillo repeat containing 1 | snRNA-activating protein complex subunit 5; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box | 0.760 |
| ARMC1 | SNX24 | ENSP00000276569 | ENSP00000261369 | Armadillo repeat containing 1 | Sorting nexin-24; May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family | 0.680 |
| ARMC9 | ARMC1 | ENSP00000484804 | ENSP00000276569 | LisH domain-containing protein ARMC9; Armadillo repeat containing 9 | Armadillo repeat containing 1 | 0.727 |
| ARMC9 | DPH5 | ENSP00000484804 | ENSP00000359127 | LisH domain-containing protein ARMC9; Armadillo repeat containing 9 | Diphthine methyl ester synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis | 0.657 |
| ARMC9 | FBXO22 | ENSP00000484804 | ENSP00000307833 | LisH domain-containing protein ARMC9; Armadillo repeat containing 9 | F-box only protein 22; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function; F-boxes other | 0.707 |
| ARMC9 | GEMIN7 | ENSP00000484804 | ENSP00000270257 | LisH domain-containing protein ARMC9; Armadillo repeat containing 9 | Gem-associated protein 7; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chapero [...] | 0.636 |
| ARMC9 | KLHDC1 | ENSP00000484804 | ENSP00000352282 | LisH domain-containing protein ARMC9; Armadillo repeat containing 9 | Kelch domain containing 1 | 0.672 |
| ARMC9 | RHBDD1 | ENSP00000484804 | ENSP00000375914 | LisH domain-containing protein ARMC9; Armadillo repeat containing 9 | Rhomboid-related protein 4; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfe [...] | 0.720 |
| ARMC9 | SIVA1 | ENSP00000484804 | ENSP00000329213 | LisH domain-containing protein ARMC9; Armadillo repeat containing 9 | Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa- B and promotes T-cell receptor-mediated apoptosis | 0.671 |
| ARMC9 | SNAPC5 | ENSP00000484804 | ENSP00000319597 | LisH domain-containing protein ARMC9; Armadillo repeat containing 9 | snRNA-activating protein complex subunit 5; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box | 0.762 |
| ARMC9 | SNX24 | ENSP00000484804 | ENSP00000261369 | LisH domain-containing protein ARMC9; Armadillo repeat containing 9 | Sorting nexin-24; May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family | 0.687 |
| ARMC9 | U2AF2 | ENSP00000484804 | ENSP00000307863 | LisH domain-containing protein ARMC9; Armadillo repeat containing 9 | Splicing factor U2AF 65 kDa subunit; Necessary for the splicing of pre-mRNA. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the [...] | 0.646 |
| DPH5 | ARMC9 | ENSP00000359127 | ENSP00000484804 | Diphthine methyl ester synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis | LisH domain-containing protein ARMC9; Armadillo repeat containing 9 | 0.657 |
| DPH5 | U2AF2 | ENSP00000359127 | ENSP00000307863 | Diphthine methyl ester synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis | Splicing factor U2AF 65 kDa subunit; Necessary for the splicing of pre-mRNA. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the [...] | 0.494 |
| FBXO22 | ARMC1 | ENSP00000307833 | ENSP00000276569 | F-box only protein 22; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function; F-boxes other | Armadillo repeat containing 1 | 0.740 |
