| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GGNBP2 | ZNHIT3 | ENSP00000478220 | ENSP00000484687 | Gametogenetin-binding protein 2; May be involved in spermatogenesis | Zinc finger HIT-type containing 3 | 0.713 |
| MED1 | THRB | ENSP00000300651 | ENSP00000379904 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Acts as a coactivator for [...] | Thyroid hormone receptor beta; Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine; Belongs to the nuclear hormone receptor family. NR1 subfamily | 0.958 |
| MED1 | TRIP4 | ENSP00000300651 | ENSP00000261884 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Acts as a coactivator for [...] | Activating signal cointegrator 1; Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation. Also involved in androgen receptor transactivation (By similarity). Plays a pivotal role in the transactivation of NF-kap [...] | 0.997 |
| MED1 | ZNHIT3 | ENSP00000300651 | ENSP00000484687 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Acts as a coactivator for [...] | Zinc finger HIT-type containing 3 | 0.760 |
| NHP2L1 | NOP58 | ENSP00000383949 | ENSP00000264279 | NHP2-like protein 1; Binds to the 5’-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding | Nucleolar protein 58; Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs; Belongs to the NOP5/NOP56 family | 0.999 |
| NHP2L1 | NUFIP1 | ENSP00000383949 | ENSP00000368459 | NHP2-like protein 1; Binds to the 5’-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding | Nuclear fragile X mental retardation-interacting protein 1; Binds RNA | 0.874 |
| NHP2L1 | RUVBL1 | ENSP00000383949 | ENSP00000318297 | NHP2-like protein 1; Binds to the 5’-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding | RuvB-like 1; May be able to bind plasminogen at cell surface and enhance plasminogen activation; AAA ATPases | 0.858 |
| NHP2L1 | ZNHIT3 | ENSP00000383949 | ENSP00000484687 | NHP2-like protein 1; Binds to the 5’-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding | Zinc finger HIT-type containing 3 | 0.755 |
| NHP2L1 | ZNHIT6 | ENSP00000383949 | ENSP00000359606 | NHP2-like protein 1; Binds to the 5’-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding | Box C/D snoRNA protein 1; Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis; Belongs to the BCD1 family | 0.736 |
| NOP58 | NHP2L1 | ENSP00000264279 | ENSP00000383949 | Nucleolar protein 58; Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs; Belongs to the NOP5/NOP56 family | NHP2-like protein 1; Binds to the 5’-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding | 0.999 |
| NOP58 | NUFIP1 | ENSP00000264279 | ENSP00000368459 | Nucleolar protein 58; Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs; Belongs to the NOP5/NOP56 family | Nuclear fragile X mental retardation-interacting protein 1; Binds RNA | 0.963 |
| NOP58 | RUVBL1 | ENSP00000264279 | ENSP00000318297 | Nucleolar protein 58; Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs; Belongs to the NOP5/NOP56 family | RuvB-like 1; May be able to bind plasminogen at cell surface and enhance plasminogen activation; AAA ATPases | 0.965 |
| NOP58 | ZNHIT3 | ENSP00000264279 | ENSP00000484687 | Nucleolar protein 58; Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs; Belongs to the NOP5/NOP56 family | Zinc finger HIT-type containing 3 | 0.828 |
| NOP58 | ZNHIT6 | ENSP00000264279 | ENSP00000359606 | Nucleolar protein 58; Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs; Belongs to the NOP5/NOP56 family | Box C/D snoRNA protein 1; Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis; Belongs to the BCD1 family | 0.964 |
| NUFIP1 | NHP2L1 | ENSP00000368459 | ENSP00000383949 | Nuclear fragile X mental retardation-interacting protein 1; Binds RNA | NHP2-like protein 1; Binds to the 5’-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding | 0.874 |
| NUFIP1 | NOP58 | ENSP00000368459 | ENSP00000264279 | Nuclear fragile X mental retardation-interacting protein 1; Binds RNA | Nucleolar protein 58; Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs; Belongs to the NOP5/NOP56 family | 0.963 |
| NUFIP1 | RUVBL1 | ENSP00000368459 | ENSP00000318297 | Nuclear fragile X mental retardation-interacting protein 1; Binds RNA | RuvB-like 1; May be able to bind plasminogen at cell surface and enhance plasminogen activation; AAA ATPases | 0.723 |
| NUFIP1 | ZNHIT1 | ENSP00000368459 | ENSP00000304593 | Nuclear fragile X mental retardation-interacting protein 1; Binds RNA | Zinc finger HIT domain-containing protein 1; Seems to play a role in p53-mediated apoptosis induction. Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity; Belongs to the ZNHIT1 family | 0.524 |
| NUFIP1 | ZNHIT3 | ENSP00000368459 | ENSP00000484687 | Nuclear fragile X mental retardation-interacting protein 1; Binds RNA | Zinc finger HIT-type containing 3 | 0.990 |
| NUFIP1 | ZNHIT6 | ENSP00000368459 | ENSP00000359606 | Nuclear fragile X mental retardation-interacting protein 1; Binds RNA | Box C/D snoRNA protein 1; Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis; Belongs to the BCD1 family | 0.936 |
