CLEC18A protein (human) - STRING database

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CLEC18A

C-type lectin domain family 18 member A; Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans; C-type lectin domain containing (446 aa)

Predicted Functional Partners:

DNAJC3

0.513

C1QTNF9B

0.475

WWP2

0.451

LRRC37B

0.446

TSKU

0.435

EPDR1

0.427

DNPH1

0.410

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1QTNF9B	CLEC18A	ENSP00000371572	ENSP00000484176	Complement C1q and tumor necrosis factor-related protein 9B; C1q and TNF related 9B	C-type lectin domain family 18 member A; Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans; C-type lectin domain containing	0.475
CLEC18A	C1QTNF9B	ENSP00000484176	ENSP00000371572	C-type lectin domain family 18 member A; Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans; C-type lectin domain containing	Complement C1q and tumor necrosis factor-related protein 9B; C1q and TNF related 9B	0.475
CLEC18A	DNAJC3	ENSP00000484176	ENSP00000473631	C-type lectin domain family 18 member A; Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans; C-type lectin domain containing	DnaJ homolog subfamily C member 3; Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at ’Ser-52’ and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2 [...]	0.513
CLEC18A	DNPH1	ENSP00000484176	ENSP00000230431	C-type lectin domain family 18 member A; Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans; C-type lectin domain containing	2’-deoxynucleoside 5’-phosphate N-hydrolase 1; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5’-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5’- monophosphates containing purine bases are preferred to those containing pyrimidine bases	0.410
CLEC18A	EPDR1	ENSP00000484176	ENSP00000199448	C-type lectin domain family 18 member A; Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans; C-type lectin domain containing	Mammalian ependymin-related protein 1; Ependymin related 1	0.427
CLEC18A	LRRC37B	ENSP00000484176	ENSP00000340519	C-type lectin domain family 18 member A; Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans; C-type lectin domain containing	Leucine-rich repeat-containing protein 37B; Leucine rich repeat containing 37B	0.446
CLEC18A	TSKU	ENSP00000484176	ENSP00000434847	C-type lectin domain family 18 member A; Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans; C-type lectin domain containing	Tsukushin; Tsukushi, small leucine rich proteoglycan	0.435
CLEC18A	WWP2	ENSP00000484176	ENSP00000352069	C-type lectin domain family 18 member A; Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans; C-type lectin domain containing	NEDD4-like E3 ubiquitin-protein ligase WWP2; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by ’Lys-63’-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation- induced cell death. Ubiquitinates SLC11A2; the ubiqu [...]	0.451
DNAJC3	CLEC18A	ENSP00000473631	ENSP00000484176	DnaJ homolog subfamily C member 3; Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at ’Ser-52’ and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2 [...]	C-type lectin domain family 18 member A; Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans; C-type lectin domain containing	0.513
DNPH1	CLEC18A	ENSP00000230431	ENSP00000484176	2’-deoxynucleoside 5’-phosphate N-hydrolase 1; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5’-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5’- monophosphates containing purine bases are preferred to those containing pyrimidine bases	C-type lectin domain family 18 member A; Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans; C-type lectin domain containing	0.410
EPDR1	CLEC18A	ENSP00000199448	ENSP00000484176	Mammalian ependymin-related protein 1; Ependymin related 1	C-type lectin domain family 18 member A; Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans; C-type lectin domain containing	0.427
EPDR1	TSKU	ENSP00000199448	ENSP00000434847	Mammalian ependymin-related protein 1; Ependymin related 1	Tsukushin; Tsukushi, small leucine rich proteoglycan	0.443
LRRC37B	CLEC18A	ENSP00000340519	ENSP00000484176	Leucine-rich repeat-containing protein 37B; Leucine rich repeat containing 37B	C-type lectin domain family 18 member A; Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans; C-type lectin domain containing	0.446
TSKU	CLEC18A	ENSP00000434847	ENSP00000484176	Tsukushin; Tsukushi, small leucine rich proteoglycan	C-type lectin domain family 18 member A; Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans; C-type lectin domain containing	0.435
TSKU	EPDR1	ENSP00000434847	ENSP00000199448	Tsukushin; Tsukushi, small leucine rich proteoglycan	Mammalian ependymin-related protein 1; Ependymin related 1	0.443
WWP2	CLEC18A	ENSP00000352069	ENSP00000484176	NEDD4-like E3 ubiquitin-protein ligase WWP2; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by ’Lys-63’-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation- induced cell death. Ubiquitinates SLC11A2; the ubiqu [...]	C-type lectin domain family 18 member A; Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans; C-type lectin domain containing	0.451

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