• Version:
  • 11.0 [archived version]
STRINGSTRING
NXPE1 NXPE1 EIF3H EIF3H WBP1L WBP1L COLCA2 COLCA2 HIGD1A HIGD1A DIP2B DIP2B POU3F1 POU3F1 C11orf53 C11orf53 FAM186A FAM186A POU2AF1 POU2AF1 SHROOM2 SHROOM2
"COLCA2" - Colorectal cancer associated 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
COLCA2Colorectal cancer associated 2 (251 aa)    
Predicted Functional Partners:
C11orf53
Uncharacterized protein C11orf53; Chromosome 11 open reading frame 53 (236 aa)
           
  0.900
HIGD1A
HIG1 domain family member 1A, mitochondrial; Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes (107 aa)
           
  0.721
WBP1L
WW domain binding protein 1 like; WBP1/VOPP1 family (363 aa)
           
  0.717
DIP2B
Disco interacting protein 2 homolog B (1576 aa)
           
  0.630
POU3F1
POU domain, class 3, transcription factor 1; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Thought to be involved in early embryogenesis and neurogenesis; POU class homeoboxes and pseudogenes (451 aa)
           
  0.575
NXPE1
NXPE family member 1; Neurexophilin and PC-esterase domain family member 1; Belongs to the NXPE family (405 aa)
           
  0.559
EIF3H
Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (352 aa)
           
  0.539
FAM186A
Protein FAM186A; Family with sequence similarity 186 member A; Belongs to the FAM186 family (2351 aa)
           
  0.530
SHROOM2
Protein Shroom2; May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity); Belongs to the shroom family (1616 aa)
           
  0.518
POU2AF1
POU domain class 2-associating factor 1; Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers; Belongs to the POU2AF1 family (256 aa)
           
  0.478
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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