| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APOBEC4 | MYO3A | ENSP00000310622 | ENSP00000265944 | Putative C->U-editing enzyme APOBEC-4; Putative C to U editing enzyme whose physiological substrate is not yet known; Apolipoprotein B mRNA editing enzyme catalytic subunits | Myosin-IIIa; Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory [...] | 0.492 |
| APOBEC4 | TRIM64 | ENSP00000310622 | ENSP00000483764 | Putative C->U-editing enzyme APOBEC-4; Putative C to U editing enzyme whose physiological substrate is not yet known; Apolipoprotein B mRNA editing enzyme catalytic subunits | Tripartite motif containing 64; Belongs to the TRIM/RBCC family | 0.408 |
| CMYA5 | TRIM42 | ENSP00000394770 | ENSP00000286349 | Cardiomyopathy-associated protein 5; May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity); A-kinase anchoring proteins | Tripartite motif-containing protein 42; Protein phosphatase 1 regulatory subunits; Belongs to the TRIM/RBCC family | 0.432 |
| CMYA5 | TRIM64 | ENSP00000394770 | ENSP00000483764 | Cardiomyopathy-associated protein 5; May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity); A-kinase anchoring proteins | Tripartite motif containing 64; Belongs to the TRIM/RBCC family | 0.432 |
| MYO3A | APOBEC4 | ENSP00000265944 | ENSP00000310622 | Myosin-IIIa; Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory [...] | Putative C->U-editing enzyme APOBEC-4; Putative C to U editing enzyme whose physiological substrate is not yet known; Apolipoprotein B mRNA editing enzyme catalytic subunits | 0.492 |
| MYO3A | TRIM64 | ENSP00000265944 | ENSP00000483764 | Myosin-IIIa; Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory [...] | Tripartite motif containing 64; Belongs to the TRIM/RBCC family | 0.454 |
| PML | TRIM42 | ENSP00000268058 | ENSP00000286349 | Protein PML; Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression- activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respe [...] | Tripartite motif-containing protein 42; Protein phosphatase 1 regulatory subunits; Belongs to the TRIM/RBCC family | 0.428 |
| PML | TRIM64 | ENSP00000268058 | ENSP00000483764 | Protein PML; Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression- activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respe [...] | Tripartite motif containing 64; Belongs to the TRIM/RBCC family | 0.404 |
| SPAG11A | TRIM64 | ENSP00000316012 | ENSP00000483764 | Sperm associated antigen 11A; Belongs to the SPAG11 family | Tripartite motif containing 64; Belongs to the TRIM/RBCC family | 0.587 |
| SPAG11B | TRIM64 | ENSP00000381480 | ENSP00000483764 | Sperm-associated antigen 11A; Sperm associated antigen 11B; Belongs to the SPAG11 family | Tripartite motif containing 64; Belongs to the TRIM/RBCC family | 0.530 |
| TRIM42 | CMYA5 | ENSP00000286349 | ENSP00000394770 | Tripartite motif-containing protein 42; Protein phosphatase 1 regulatory subunits; Belongs to the TRIM/RBCC family | Cardiomyopathy-associated protein 5; May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity); A-kinase anchoring proteins | 0.432 |
| TRIM42 | PML | ENSP00000286349 | ENSP00000268058 | Tripartite motif-containing protein 42; Protein phosphatase 1 regulatory subunits; Belongs to the TRIM/RBCC family | Protein PML; Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression- activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respe [...] | 0.428 |
| TRIM42 | TRIM64 | ENSP00000286349 | ENSP00000483764 | Tripartite motif-containing protein 42; Protein phosphatase 1 regulatory subunits; Belongs to the TRIM/RBCC family | Tripartite motif containing 64; Belongs to the TRIM/RBCC family | 0.559 |
| TRIM64 | APOBEC4 | ENSP00000483764 | ENSP00000310622 | Tripartite motif containing 64; Belongs to the TRIM/RBCC family | Putative C->U-editing enzyme APOBEC-4; Putative C to U editing enzyme whose physiological substrate is not yet known; Apolipoprotein B mRNA editing enzyme catalytic subunits | 0.408 |
| TRIM64 | CMYA5 | ENSP00000483764 | ENSP00000394770 | Tripartite motif containing 64; Belongs to the TRIM/RBCC family | Cardiomyopathy-associated protein 5; May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity); A-kinase anchoring proteins | 0.432 |
| TRIM64 | MYO3A | ENSP00000483764 | ENSP00000265944 | Tripartite motif containing 64; Belongs to the TRIM/RBCC family | Myosin-IIIa; Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory [...] | 0.454 |
| TRIM64 | PML | ENSP00000483764 | ENSP00000268058 | Tripartite motif containing 64; Belongs to the TRIM/RBCC family | Protein PML; Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression- activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respe [...] | 0.404 |
| TRIM64 | SPAG11A | ENSP00000483764 | ENSP00000316012 | Tripartite motif containing 64; Belongs to the TRIM/RBCC family | Sperm associated antigen 11A; Belongs to the SPAG11 family | 0.587 |
| TRIM64 | SPAG11B | ENSP00000483764 | ENSP00000381480 | Tripartite motif containing 64; Belongs to the TRIM/RBCC family | Sperm-associated antigen 11A; Sperm associated antigen 11B; Belongs to the SPAG11 family | 0.530 |
| TRIM64 | TRIM42 | ENSP00000483764 | ENSP00000286349 | Tripartite motif containing 64; Belongs to the TRIM/RBCC family | Tripartite motif-containing protein 42; Protein phosphatase 1 regulatory subunits; Belongs to the TRIM/RBCC family | 0.559 |
