• Version:
  • 11.0 [archived version]
STRINGSTRING
CLEC2D CLEC2D PLEK PLEK TAGAP TAGAP CD48 CD48 CD69 CD69 ADAD1 ADAD1 BTLA BTLA CLECL1 CLECL1 CHST10 CHST10 LONRF2 LONRF2 RPS26 RPS26
"CLECL1" - C-type lectin-like domain family 1 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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CLECL1C-type lectin-like domain family 1; May function in mediating immune cell-cell interactions. May act as a T-cell costimulatory molecule, enhancing anti-CD3- induced proliferation. May play a role in the interaction of dendritic cells with T-cells and the cells of the adaptive immune response (191 aa)    
Predicted Functional Partners:
CD69
Early activation antigen CD69; Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets; C-type lectin domain containing (199 aa)
     
   
  0.678
LONRF2
LON peptidase N-terminal domain and ring finger 2 (754 aa)
       
 
  0.655
CHST10
Carbohydrate sulfotransferase 10; Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis; Sulfotransferases, membrane bound (356 aa)
           
  0.636
CLEC2D
C-type lectin domain family 2 member D; Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon-gamma. Binds high molecular weight sulfated glycosaminoglycans; C-type lectin domain containing (194 aa)
     
   
  0.624
RPS26
Ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family (115 aa)
           
  0.606
CD48
CD48 antigen; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation (252 aa)
     
        0.552
TAGAP
T-cell activation Rho GTPase-activating protein; May function as a GTPase-activating protein and may play important roles during T-cell activation (731 aa)
     
   
  0.542
BTLA
B- and T-lymphocyte attenuator; Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response; CD molecules (289 aa)
     
        0.525
ADAD1
Adenosine deaminase domain-containing protein 1; Plays a role in spermatogenesis. Binds to RNA but not to DNA (By similarity); Adenosine deaminases acting on RNA (576 aa)
           
  0.519
PLEK
Pleckstrin; Major protein kinase C substrate of platelets; Pleckstrin homology domain containing (350 aa)
     
        0.507
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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