SPON2 protein (human) - STRING database

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SPON2

Spondin-2; Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern- recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS) (331 aa)

Predicted Functional Partners:

THBS2

0.921

THSD1

0.920

CFP

0.919

THBS1

0.914

ITGB2

0.912

SPON1

0.912

ADAMTSL4

0.910

ADAMTS9

0.908

ADAMTS6

0.907

ADAMTSL1

0.907

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTS6	ADAMTS9	ENSP00000370443	ENSP00000418735	ADAM metallopeptidase with thrombospondin type 1 motif 6	A disintegrin and metalloproteinase with thrombospondin motifs 9; Cleaves the large aggregating proteoglycans, aggrecan (at the ’1838-Glu-\|-Ala-1839’ site) and versican (at the ’1428- Glu-\|-Ala-1429’ site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos; ADAM metallopeptidases with thrombospondin type 1 motif	0.912
ADAMTS6	ADAMTSL1	ENSP00000370443	ENSP00000369921	ADAM metallopeptidase with thrombospondin type 1 motif 6	ADAMTS-like protein 1; I-set domain containing; ADAMTS like	0.919
ADAMTS6	ADAMTSL4	ENSP00000370443	ENSP00000358035	ADAM metallopeptidase with thrombospondin type 1 motif 6	ADAMTS-like protein 4; Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis; ADAMTS like	0.918
ADAMTS6	CFP	ENSP00000370443	ENSP00000247153	ADAM metallopeptidase with thrombospondin type 1 motif 6	Properdin; A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes	0.902
ADAMTS6	SPON1	ENSP00000370443	ENSP00000460236	ADAM metallopeptidase with thrombospondin type 1 motif 6	Spondin-1; Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell	0.910
ADAMTS6	SPON2	ENSP00000370443	ENSP00000483599	ADAM metallopeptidase with thrombospondin type 1 motif 6	Spondin-2; Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern- recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS)	0.907
ADAMTS6	THBS1	ENSP00000370443	ENSP00000260356	ADAM metallopeptidase with thrombospondin type 1 motif 6	Thrombospondin-1; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity)	0.917
ADAMTS6	THBS2	ENSP00000370443	ENSP00000355751	ADAM metallopeptidase with thrombospondin type 1 motif 6	Thrombospondin-2; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties	0.904
ADAMTS6	THSD1	ENSP00000370443	ENSP00000258613	ADAM metallopeptidase with thrombospondin type 1 motif 6	Thrombospondin type-1 domain-containing protein 1; Thrombospondin type 1 domain containing 1	0.902
ADAMTS9	ADAMTS6	ENSP00000418735	ENSP00000370443	A disintegrin and metalloproteinase with thrombospondin motifs 9; Cleaves the large aggregating proteoglycans, aggrecan (at the ’1838-Glu-\|-Ala-1839’ site) and versican (at the ’1428- Glu-\|-Ala-1429’ site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos; ADAM metallopeptidases with thrombospondin type 1 motif	ADAM metallopeptidase with thrombospondin type 1 motif 6	0.912
ADAMTS9	ADAMTSL1	ENSP00000418735	ENSP00000369921	A disintegrin and metalloproteinase with thrombospondin motifs 9; Cleaves the large aggregating proteoglycans, aggrecan (at the ’1838-Glu-\|-Ala-1839’ site) and versican (at the ’1428- Glu-\|-Ala-1429’ site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos; ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS-like protein 1; I-set domain containing; ADAMTS like	0.927
ADAMTS9	ADAMTSL4	ENSP00000418735	ENSP00000358035	A disintegrin and metalloproteinase with thrombospondin motifs 9; Cleaves the large aggregating proteoglycans, aggrecan (at the ’1838-Glu-\|-Ala-1839’ site) and versican (at the ’1428- Glu-\|-Ala-1429’ site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos; ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS-like protein 4; Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis; ADAMTS like	0.916
ADAMTS9	CFP	ENSP00000418735	ENSP00000247153	A disintegrin and metalloproteinase with thrombospondin motifs 9; Cleaves the large aggregating proteoglycans, aggrecan (at the ’1838-Glu-\|-Ala-1839’ site) and versican (at the ’1428- Glu-\|-Ala-1429’ site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos; ADAM metallopeptidases with thrombospondin type 1 motif	Properdin; A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes	0.900
ADAMTS9	SPON1	ENSP00000418735	ENSP00000460236	A disintegrin and metalloproteinase with thrombospondin motifs 9; Cleaves the large aggregating proteoglycans, aggrecan (at the ’1838-Glu-\|-Ala-1839’ site) and versican (at the ’1428- Glu-\|-Ala-1429’ site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos; ADAM metallopeptidases with thrombospondin type 1 motif	Spondin-1; Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell	0.907
ADAMTS9	SPON2	ENSP00000418735	ENSP00000483599	A disintegrin and metalloproteinase with thrombospondin motifs 9; Cleaves the large aggregating proteoglycans, aggrecan (at the ’1838-Glu-\|-Ala-1839’ site) and versican (at the ’1428- Glu-\|-Ala-1429’ site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos; ADAM metallopeptidases with thrombospondin type 1 motif	Spondin-2; Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern- recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS)	0.908
ADAMTS9	THBS1	ENSP00000418735	ENSP00000260356	A disintegrin and metalloproteinase with thrombospondin motifs 9; Cleaves the large aggregating proteoglycans, aggrecan (at the ’1838-Glu-\|-Ala-1839’ site) and versican (at the ’1428- Glu-\|-Ala-1429’ site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos; ADAM metallopeptidases with thrombospondin type 1 motif	Thrombospondin-1; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity)	0.913
ADAMTS9	THBS2	ENSP00000418735	ENSP00000355751	A disintegrin and metalloproteinase with thrombospondin motifs 9; Cleaves the large aggregating proteoglycans, aggrecan (at the ’1838-Glu-\|-Ala-1839’ site) and versican (at the ’1428- Glu-\|-Ala-1429’ site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos; ADAM metallopeptidases with thrombospondin type 1 motif	Thrombospondin-2; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties	0.911
ADAMTS9	THSD1	ENSP00000418735	ENSP00000258613	A disintegrin and metalloproteinase with thrombospondin motifs 9; Cleaves the large aggregating proteoglycans, aggrecan (at the ’1838-Glu-\|-Ala-1839’ site) and versican (at the ’1428- Glu-\|-Ala-1429’ site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos; ADAM metallopeptidases with thrombospondin type 1 motif	Thrombospondin type-1 domain-containing protein 1; Thrombospondin type 1 domain containing 1	0.902
ADAMTSL1	ADAMTS6	ENSP00000369921	ENSP00000370443	ADAMTS-like protein 1; I-set domain containing; ADAMTS like	ADAM metallopeptidase with thrombospondin type 1 motif 6	0.919
ADAMTSL1	ADAMTS9	ENSP00000369921	ENSP00000418735	ADAMTS-like protein 1; I-set domain containing; ADAMTS like	A disintegrin and metalloproteinase with thrombospondin motifs 9; Cleaves the large aggregating proteoglycans, aggrecan (at the ’1838-Glu-\|-Ala-1839’ site) and versican (at the ’1428- Glu-\|-Ala-1429’ site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos; ADAM metallopeptidases with thrombospondin type 1 motif	0.927

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