node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FAM221A | HEATR9 | ENSP00000342576 | ENSP00000473941 | Protein FAM221A; Family with sequence similarity 221 member A; Belongs to the FAM221 family | Protein HEATR9; Armadillo-like helical domain containing | 0.595 |
FAM221A | OR6T1 | ENSP00000342576 | ENSP00000325203 | Protein FAM221A; Family with sequence similarity 221 member A; Belongs to the FAM221 family | Olfactory receptor 6T1; Odorant receptor; Olfactory receptors, family 6 | 0.668 |
FAM221A | RDM1 | ENSP00000342576 | ENSP00000483549 | Protein FAM221A; Family with sequence similarity 221 member A; Belongs to the FAM221 family | RAD52 motif-containing protein 1; May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA; RNA binding motif containing | 0.451 |
HEATR9 | FAM221A | ENSP00000473941 | ENSP00000342576 | Protein HEATR9; Armadillo-like helical domain containing | Protein FAM221A; Family with sequence similarity 221 member A; Belongs to the FAM221 family | 0.595 |
HEATR9 | OR6T1 | ENSP00000473941 | ENSP00000325203 | Protein HEATR9; Armadillo-like helical domain containing | Olfactory receptor 6T1; Odorant receptor; Olfactory receptors, family 6 | 0.700 |
HEATR9 | RDM1 | ENSP00000473941 | ENSP00000483549 | Protein HEATR9; Armadillo-like helical domain containing | RAD52 motif-containing protein 1; May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA; RNA binding motif containing | 0.480 |
OR6T1 | FAM221A | ENSP00000325203 | ENSP00000342576 | Olfactory receptor 6T1; Odorant receptor; Olfactory receptors, family 6 | Protein FAM221A; Family with sequence similarity 221 member A; Belongs to the FAM221 family | 0.668 |
OR6T1 | HEATR9 | ENSP00000325203 | ENSP00000473941 | Olfactory receptor 6T1; Odorant receptor; Olfactory receptors, family 6 | Protein HEATR9; Armadillo-like helical domain containing | 0.700 |
OR6T1 | RDM1 | ENSP00000325203 | ENSP00000483549 | Olfactory receptor 6T1; Odorant receptor; Olfactory receptors, family 6 | RAD52 motif-containing protein 1; May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA; RNA binding motif containing | 0.530 |
PI4KB | RDM1 | ENSP00000357869 | ENSP00000483549 | Phosphatidylinositol 4-kinase beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity); Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily | RAD52 motif-containing protein 1; May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA; RNA binding motif containing | 0.455 |
PLEKHM1 | RDM1 | ENSP00000389913 | ENSP00000483549 | Pleckstrin homology domain-containing family M member 1; Proposed to act as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Seems to be involved in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion. Positively regulates lysosome peripheral distributi [...] | RAD52 motif-containing protein 1; May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA; RNA binding motif containing | 0.468 |
PSMC5 | RDM1 | ENSP00000310572 | ENSP00000483549 | 26S proteasome regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with [...] | RAD52 motif-containing protein 1; May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA; RNA binding motif containing | 0.485 |
RAD52 | RDM1 | ENSP00000351284 | ENSP00000483549 | DNA repair protein RAD52 homolog; Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase; Belongs to the RAD52 family | RAD52 motif-containing protein 1; May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA; RNA binding motif containing | 0.793 |
RAD52 | WDHD1 | ENSP00000351284 | ENSP00000353793 | DNA repair protein RAD52 homolog; Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase; Belongs to the RAD52 family | WD repeat and HMG-box DNA-binding protein 1; Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication; WD repeat domain containing | 0.805 |
RDM1 | FAM221A | ENSP00000483549 | ENSP00000342576 | RAD52 motif-containing protein 1; May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA; RNA binding motif containing | Protein FAM221A; Family with sequence similarity 221 member A; Belongs to the FAM221 family | 0.451 |
RDM1 | HEATR9 | ENSP00000483549 | ENSP00000473941 | RAD52 motif-containing protein 1; May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA; RNA binding motif containing | Protein HEATR9; Armadillo-like helical domain containing | 0.480 |
RDM1 | OR6T1 | ENSP00000483549 | ENSP00000325203 | RAD52 motif-containing protein 1; May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA; RNA binding motif containing | Olfactory receptor 6T1; Odorant receptor; Olfactory receptors, family 6 | 0.530 |
RDM1 | PI4KB | ENSP00000483549 | ENSP00000357869 | RAD52 motif-containing protein 1; May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA; RNA binding motif containing | Phosphatidylinositol 4-kinase beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity); Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily | 0.455 |
RDM1 | PLEKHM1 | ENSP00000483549 | ENSP00000389913 | RAD52 motif-containing protein 1; May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA; RNA binding motif containing | Pleckstrin homology domain-containing family M member 1; Proposed to act as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Seems to be involved in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion. Positively regulates lysosome peripheral distributi [...] | 0.468 |
RDM1 | PSMC5 | ENSP00000483549 | ENSP00000310572 | RAD52 motif-containing protein 1; May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA; RNA binding motif containing | 26S proteasome regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with [...] | 0.485 |