| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C11orf65 | CUL5 | ENSP00000483537 | ENSP00000376808 | Uncharacterized protein C11orf65; Chromosome 11 open reading frame 65 | Cullin-5; Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulate [...] | 0.455 |
| C11orf65 | DCAF4L2 | ENSP00000483537 | ENSP00000316496 | Uncharacterized protein C11orf65; Chromosome 11 open reading frame 65 | DDB1- and CUL4-associated factor 4-like protein 2; DDB1 and CUL4 associated factor 4 like 2; WD repeat domain containing | 0.529 |
| C11orf65 | DMXL2 | ENSP00000483537 | ENSP00000441858 | Uncharacterized protein C11orf65; Chromosome 11 open reading frame 65 | DmX-like protein 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity); Deafness associated genes | 0.406 |
| C11orf65 | EXPH5 | ENSP00000483537 | ENSP00000265843 | Uncharacterized protein C11orf65; Chromosome 11 open reading frame 65 | Exophilin-5; May act as Rab effector protein and play a role in vesicle trafficking | 0.685 |
| C11orf65 | IKZF5 | ENSP00000483537 | ENSP00000357881 | Uncharacterized protein C11orf65; Chromosome 11 open reading frame 65 | Zinc finger protein Pegasus; DNA-binding protein that binds to the 5’GNNTGTNG-3’ core sequence. Transcriptional repressor; Zinc fingers C2H2-type | 0.440 |
| C11orf65 | KDELC2 | ENSP00000483537 | ENSP00000315386 | Uncharacterized protein C11orf65; Chromosome 11 open reading frame 65 | KDEL motif-containing protein 2; Glycosyltransferase family 90; Belongs to the KDELC family | 0.814 |
| C11orf65 | NPAT | ENSP00000483537 | ENSP00000278612 | Uncharacterized protein C11orf65; Chromosome 11 open reading frame 65 | Protein NPAT; Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters; Belongs to the NPAT family | 0.477 |
| C11orf65 | SLC35F2 | ENSP00000483537 | ENSP00000436785 | Uncharacterized protein C11orf65; Chromosome 11 open reading frame 65 | Solute carrier family 35 member F2; Putative solute transporter | 0.426 |
| C11orf65 | SUMO1 | ENSP00000483537 | ENSP00000376077 | Uncharacterized protein C11orf65; Chromosome 11 open reading frame 65 | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instan [...] | 0.547 |
| C11orf65 | TNFAIP8L3 | ENSP00000483537 | ENSP00000328016 | Uncharacterized protein C11orf65; Chromosome 11 open reading frame 65 | Tumor necrosis factor alpha-induced protein 8-like protein 3; Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling; Belongs to the TNFAIP8 family | 0.433 |
| CUL5 | C11orf65 | ENSP00000376808 | ENSP00000483537 | Cullin-5; Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulate [...] | Uncharacterized protein C11orf65; Chromosome 11 open reading frame 65 | 0.455 |
| CUL5 | KDELC2 | ENSP00000376808 | ENSP00000315386 | Cullin-5; Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulate [...] | KDEL motif-containing protein 2; Glycosyltransferase family 90; Belongs to the KDELC family | 0.483 |
| DCAF4L2 | C11orf65 | ENSP00000316496 | ENSP00000483537 | DDB1- and CUL4-associated factor 4-like protein 2; DDB1 and CUL4 associated factor 4 like 2; WD repeat domain containing | Uncharacterized protein C11orf65; Chromosome 11 open reading frame 65 | 0.529 |
| DMXL2 | C11orf65 | ENSP00000441858 | ENSP00000483537 | DmX-like protein 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity); Deafness associated genes | Uncharacterized protein C11orf65; Chromosome 11 open reading frame 65 | 0.406 |
| DMXL2 | KDELC2 | ENSP00000441858 | ENSP00000315386 | DmX-like protein 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity); Deafness associated genes | KDEL motif-containing protein 2; Glycosyltransferase family 90; Belongs to the KDELC family | 0.451 |
| DMXL2 | SLC35F2 | ENSP00000441858 | ENSP00000436785 | DmX-like protein 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity); Deafness associated genes | Solute carrier family 35 member F2; Putative solute transporter | 0.476 |
| DMXL2 | TNFAIP8L3 | ENSP00000441858 | ENSP00000328016 | DmX-like protein 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity); Deafness associated genes | Tumor necrosis factor alpha-induced protein 8-like protein 3; Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling; Belongs to the TNFAIP8 family | 0.517 |
| EXPH5 | C11orf65 | ENSP00000265843 | ENSP00000483537 | Exophilin-5; May act as Rab effector protein and play a role in vesicle trafficking | Uncharacterized protein C11orf65; Chromosome 11 open reading frame 65 | 0.685 |
| EXPH5 | KDELC2 | ENSP00000265843 | ENSP00000315386 | Exophilin-5; May act as Rab effector protein and play a role in vesicle trafficking | KDEL motif-containing protein 2; Glycosyltransferase family 90; Belongs to the KDELC family | 0.684 |
| EXPH5 | NPAT | ENSP00000265843 | ENSP00000278612 | Exophilin-5; May act as Rab effector protein and play a role in vesicle trafficking | Protein NPAT; Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters; Belongs to the NPAT family | 0.481 |
