| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DIS3L | RBM26 | ENSP00000321711 | ENSP00000483408 | DIS3-like exonuclease 1; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3’ untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA | RNA-binding protein 26; Protein phosphatase 1 regulatory subunits | 0.607 |
| PRPF3 | RBM26 | ENSP00000315379 | ENSP00000483408 | U4/U6 small nuclear ribonucleoprotein Prp3; Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | RNA-binding protein 26; Protein phosphatase 1 regulatory subunits | 0.676 |
| RBM26 | DIS3L | ENSP00000483408 | ENSP00000321711 | RNA-binding protein 26; Protein phosphatase 1 regulatory subunits | DIS3-like exonuclease 1; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3’ untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA | 0.607 |
| RBM26 | PRPF3 | ENSP00000483408 | ENSP00000315379 | RNA-binding protein 26; Protein phosphatase 1 regulatory subunits | U4/U6 small nuclear ribonucleoprotein Prp3; Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | 0.676 |
| RBM26 | SLA | ENSP00000483408 | ENSP00000394049 | RNA-binding protein 26; Protein phosphatase 1 regulatory subunits | Src-like-adapter; Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins; SH2 domain containing | 0.641 |
| RBM26 | THOC2 | ENSP00000483408 | ENSP00000245838 | RNA-binding protein 26; Protein phosphatase 1 regulatory subunits | THO complex subunit 2; Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5’ end of the mRNA where it functions in mRNA export to the cyt [...] | 0.606 |
| RBM26 | TP53BP1 | ENSP00000483408 | ENSP00000371475 | RNA-binding protein 26; Protein phosphatase 1 regulatory subunits | TP53-binding protein 1; Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs si [...] | 0.682 |
| RBM26 | ZC3H10 | ENSP00000483408 | ENSP00000257940 | RNA-binding protein 26; Protein phosphatase 1 regulatory subunits | Zinc finger CCCH domain-containing protein 10; Specific regulator of miRNA biogenesis. Binds, via the C3H1-type zinc finger domains, to the binding motif 5’-GCAGCGC-3’ on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA; Zinc fingers CCCH-type | 0.681 |
| RBM26 | ZC3H15 | ENSP00000483408 | ENSP00000338788 | RNA-binding protein 26; Protein phosphatase 1 regulatory subunits | Zinc finger CCCH domain-containing protein 15; Protects DRG1 from proteolytic degradation; Zinc fingers CCCH-type | 0.625 |
| RBM26 | ZC3H3 | ENSP00000483408 | ENSP00000262577 | RNA-binding protein 26; Protein phosphatase 1 regulatory subunits | Zinc finger CCCH domain-containing protein 3; Required for the export of polyadenylated mRNAs from the nucleus. Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double- stranded DNA in vitro. Involved in RNA cleavage (By similarity); Zinc fingers CCCH-type | 0.611 |
| RBM26 | ZC3H4 | ENSP00000483408 | ENSP00000253048 | RNA-binding protein 26; Protein phosphatase 1 regulatory subunits | Zinc finger CCCH domain-containing protein 4; Armadillo-like helical domain containing | 0.634 |
| RBM26 | ZC3HAV1L | ENSP00000483408 | ENSP00000275766 | RNA-binding protein 26; Protein phosphatase 1 regulatory subunits | Zinc finger CCCH-type containing, antiviral 1 like | 0.640 |
| SLA | RBM26 | ENSP00000394049 | ENSP00000483408 | Src-like-adapter; Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins; SH2 domain containing | RNA-binding protein 26; Protein phosphatase 1 regulatory subunits | 0.641 |
| THOC2 | RBM26 | ENSP00000245838 | ENSP00000483408 | THO complex subunit 2; Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5’ end of the mRNA where it functions in mRNA export to the cyt [...] | RNA-binding protein 26; Protein phosphatase 1 regulatory subunits | 0.606 |
| THOC2 | TP53BP1 | ENSP00000245838 | ENSP00000371475 | THO complex subunit 2; Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5’ end of the mRNA where it functions in mRNA export to the cyt [...] | TP53-binding protein 1; Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs si [...] | 0.675 |
| THOC2 | ZC3H15 | ENSP00000245838 | ENSP00000338788 | THO complex subunit 2; Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5’ end of the mRNA where it functions in mRNA export to the cyt [...] | Zinc finger CCCH domain-containing protein 15; Protects DRG1 from proteolytic degradation; Zinc fingers CCCH-type | 0.855 |
| TP53BP1 | RBM26 | ENSP00000371475 | ENSP00000483408 | TP53-binding protein 1; Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs si [...] | RNA-binding protein 26; Protein phosphatase 1 regulatory subunits | 0.682 |
| TP53BP1 | THOC2 | ENSP00000371475 | ENSP00000245838 | TP53-binding protein 1; Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs si [...] | THO complex subunit 2; Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5’ end of the mRNA where it functions in mRNA export to the cyt [...] | 0.675 |
| TP53BP1 | ZC3H4 | ENSP00000371475 | ENSP00000253048 | TP53-binding protein 1; Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs si [...] | Zinc finger CCCH domain-containing protein 4; Armadillo-like helical domain containing | 0.694 |
| ZC3H10 | RBM26 | ENSP00000257940 | ENSP00000483408 | Zinc finger CCCH domain-containing protein 10; Specific regulator of miRNA biogenesis. Binds, via the C3H1-type zinc finger domains, to the binding motif 5’-GCAGCGC-3’ on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA; Zinc fingers CCCH-type | RNA-binding protein 26; Protein phosphatase 1 regulatory subunits | 0.681 |
