• Version:
  • 11.0 [archived version]
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SEPT9 SEPT9 SLC5A8 SLC5A8 KIRREL2 KIRREL2 IRX1 IRX1 SKOR2 SKOR2 EVX2 EVX2 SMAD3 SMAD3 SMAD2 SMAD2 TBC1D12 TBC1D12 HDHD2 HDHD2 NOC3L NOC3L
"SKOR2" - SKI family transcriptional corepressor 2 in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SKOR2SKI family transcriptional corepressor 2; Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervous system; SKI transcriptional corepressors (1015 aa)    
Predicted Functional Partners:
HDHD2
Haloacid dehalogenase like hydrolase domain containing 2 (259 aa)
           
  0.703
SMAD2
Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (467 aa)
       
 
  0.668
EVX2
Homeobox even-skipped homolog protein 2; HOXL subclass homeoboxes; Belongs to the even-skipped homeobox family (476 aa)
     
   
  0.606
SMAD3
Mothers against decapentaplegic homolog 3; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and mi [...] (425 aa)
       
 
  0.590
KIRREL2
Kin of IRRE-like protein 2; Kirre like nephrin family adhesion molecule 2; C2-set domain containing (708 aa)
           
  0.589
SLC5A8
Sodium-coupled monocarboxylate transporter 1; Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D- hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+)-substrate stoichiometry of between 4-1 and 2-1. Catalyzes passive carrier mediated diffusion of iodide. Med [...] (610 aa)
           
  0.582
TBC1D12
TBC1 domain family member 12; May act as a GTPase-activating protein for Rab family protein(s) (775 aa)
           
  0.557
SEPT9
Septin-9; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. Septin GTPase family (586 aa)
           
  0.556
IRX1
Iroquois-class homeodomain protein IRX-1; TALE class homeoboxes and pseudogenes (480 aa)
           
  0.543
NOC3L
Nucleolar complex protein 3 homolog; May be required for adipogenesis; Armadillo-like helical domain containing (800 aa)
           
  0.539
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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