| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABHD16A | TMEM222 | ENSP00000379282 | ENSP00000483276 | Protein ABHD16A; Abhydrolase domain containing 16A | Transmembrane protein 222 | 0.552 |
| ARL4C | TMEM222 | ENSP00000339754 | ENSP00000483276 | ADP-ribosylation factor-like protein 4C; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the [...] | Transmembrane protein 222 | 0.471 |
| FKBP7 | TMEM222 | ENSP00000413152 | ENSP00000483276 | Peptidylprolyl isomerase; EF-hand domain containing | Transmembrane protein 222 | 0.453 |
| POLR1C | TMEM222 | ENSP00000361465 | ENSP00000483276 | DNA-directed RNA polymerases I and III subunit RPAC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity) | Transmembrane protein 222 | 0.531 |
| POLR1C | TRMT6 | ENSP00000361465 | ENSP00000203001 | DNA-directed RNA polymerases I and III subunit RPAC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity) | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Together with the TRMT61A catalytic subunit, part of a mRNA N(1)-methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs- N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries | 0.754 |
| SNRPA1 | TMEM222 | ENSP00000254193 | ENSP00000483276 | U2 small nuclear ribonucleoprotein A; This protein is associated with sn-RNP U2. It helps the A’ protein to bind stem loop IV of U2 snRNA; Belongs to the U2 small nuclear ribonucleoprotein A family | Transmembrane protein 222 | 0.559 |
| STXBP1 | TMEM222 | ENSP00000362399 | ENSP00000483276 | Syntaxin-binding protein 1; May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1-1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions | Transmembrane protein 222 | 0.658 |
| TMEM222 | ABHD16A | ENSP00000483276 | ENSP00000379282 | Transmembrane protein 222 | Protein ABHD16A; Abhydrolase domain containing 16A | 0.552 |
| TMEM222 | ARL4C | ENSP00000483276 | ENSP00000339754 | Transmembrane protein 222 | ADP-ribosylation factor-like protein 4C; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the [...] | 0.471 |
| TMEM222 | FKBP7 | ENSP00000483276 | ENSP00000413152 | Transmembrane protein 222 | Peptidylprolyl isomerase; EF-hand domain containing | 0.453 |
| TMEM222 | POLR1C | ENSP00000483276 | ENSP00000361465 | Transmembrane protein 222 | DNA-directed RNA polymerases I and III subunit RPAC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity) | 0.531 |
| TMEM222 | SNRPA1 | ENSP00000483276 | ENSP00000254193 | Transmembrane protein 222 | U2 small nuclear ribonucleoprotein A; This protein is associated with sn-RNP U2. It helps the A’ protein to bind stem loop IV of U2 snRNA; Belongs to the U2 small nuclear ribonucleoprotein A family | 0.559 |
| TMEM222 | STXBP1 | ENSP00000483276 | ENSP00000362399 | Transmembrane protein 222 | Syntaxin-binding protein 1; May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1-1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions | 0.658 |
| TMEM222 | TRMT6 | ENSP00000483276 | ENSP00000203001 | Transmembrane protein 222 | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Together with the TRMT61A catalytic subunit, part of a mRNA N(1)-methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs- N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries | 0.522 |
| TMEM222 | TTLL10 | ENSP00000483276 | ENSP00000368592 | Transmembrane protein 222 | Inactive polyglycylase TTLL10; Inactive polyglycylase; Tubulin tyrosine ligase family | 0.517 |
| TMEM222 | UBTD1 | ENSP00000483276 | ENSP00000359698 | Transmembrane protein 222 | Ubiquitin domain-containing protein 1; May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2 | 0.815 |
| TMEM222 | UBTD2 | ENSP00000483276 | ENSP00000377381 | Transmembrane protein 222 | Ubiquitin domain containing 2 | 0.449 |
| TRMT6 | POLR1C | ENSP00000203001 | ENSP00000361465 | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Together with the TRMT61A catalytic subunit, part of a mRNA N(1)-methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs- N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries | DNA-directed RNA polymerases I and III subunit RPAC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity) | 0.754 |
| TRMT6 | TMEM222 | ENSP00000203001 | ENSP00000483276 | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Together with the TRMT61A catalytic subunit, part of a mRNA N(1)-methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs- N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries | Transmembrane protein 222 | 0.522 |
| TTLL10 | TMEM222 | ENSP00000368592 | ENSP00000483276 | Inactive polyglycylase TTLL10; Inactive polyglycylase; Tubulin tyrosine ligase family | Transmembrane protein 222 | 0.517 |
