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STRINGSTRING
KNDC1 KNDC1 ENSG00000259305 ENSG00000259305 C8orf76 C8orf76 SRPX SRPX PAMR1 PAMR1 SLC1A2 SLC1A2 LDLRAD3 LDLRAD3 ACOT11 ACOT11 FAM188A FAM188A MICAL3 MICAL3 NEBL NEBL
"PAMR1" - Inactive serine protease PAMR1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
PAMR1Inactive serine protease PAMR1; May play a role in regeneration of skeletal muscle; Belongs to the peptidase S1 family (737 aa)    
Predicted Functional Partners:
SLC1A2
Excitatory amino acid transporter 2; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminatin [...] (574 aa)
      
   
  0.728
FAM188A
Ubiquitin carboxyl-terminal hydrolase MINDY-3; Hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins (445 aa)
            
  0.658
SRPX
Sushi repeat-containing protein SRPX; May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction; Sushi domain containing (464 aa)
      
   
  0.572
NEBL
Nebulette; Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres. Isoform 2 might play a role in the assembly of focal adhesion; LIM domain containing (1014 aa)
            
  0.570
KNDC1
Protein very KIND; RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence (1749 aa)
      
   
  0.551
ACOT11
Acyl-coenzyme A thioesterase 11; Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates (607 aa)
      
   
  0.547
LDLRAD3
Low-density lipoprotein receptor class A domain-containing protein 3; May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production (345 aa)
            
  0.542
MICAL3
[F-actin]-monooxygenase MICAL3; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion- the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required fo [...] (2002 aa)
            
  0.532
ENSG00000259305
Zinc fingers and homeoboxes protein 1, isoform 2; ZHX1-C8orf76 readthrough (292 aa)
            
  0.527
C8orf76
Uncharacterized protein C8orf76; Chromosome 8 open reading frame 76 (380 aa)
            
  0.527
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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