node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C5orf22 | CHAMP1 | ENSP00000326879 | ENSP00000354730 | UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family | Chromosome alignment-maintaining phosphoprotein 1; Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore; Zinc fingers C2H2-type | 0.636 |
C5orf22 | LRRC8B | ENSP00000326879 | ENSP00000332674 | UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family | Volume-regulated anion channel subunit LRRC8B; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition | 0.627 |
C5orf22 | PIGH | ENSP00000326879 | ENSP00000216452 | UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family | Phosphatidylinositol N-acetylglucosaminyltransferase subunit H; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis | 0.628 |
C5orf22 | SAYSD1 | ENSP00000326879 | ENSP00000229903 | UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family | SAYSVFN motif domain containing 1 | 0.734 |
C5orf22 | TPSAB1 | ENSP00000326879 | ENSP00000343577 | UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family | Tryptase alpha/beta-1; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates; Belongs to the peptidase S1 family. Tryptase subfamily | 0.432 |
C5orf22 | TPSB2 | ENSP00000326879 | ENSP00000482743 | UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family | Tryptase beta 2; Belongs to the peptidase S1 family | 0.492 |
C5orf22 | TRMT13 | ENSP00000326879 | ENSP00000359160 | UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family | tRNA-m(4)X modification enzyme TRM13 homolog; tRNA methylase which 2’-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His) | 0.753 |
CHAMP1 | C5orf22 | ENSP00000354730 | ENSP00000326879 | Chromosome alignment-maintaining phosphoprotein 1; Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore; Zinc fingers C2H2-type | UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family | 0.636 |
CHAMP1 | LRRC8B | ENSP00000354730 | ENSP00000332674 | Chromosome alignment-maintaining phosphoprotein 1; Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore; Zinc fingers C2H2-type | Volume-regulated anion channel subunit LRRC8B; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition | 0.576 |
CHAMP1 | PIGH | ENSP00000354730 | ENSP00000216452 | Chromosome alignment-maintaining phosphoprotein 1; Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore; Zinc fingers C2H2-type | Phosphatidylinositol N-acetylglucosaminyltransferase subunit H; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis | 0.596 |
CHAMP1 | SAYSD1 | ENSP00000354730 | ENSP00000229903 | Chromosome alignment-maintaining phosphoprotein 1; Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore; Zinc fingers C2H2-type | SAYSVFN motif domain containing 1 | 0.670 |
CHAMP1 | TPSB2 | ENSP00000354730 | ENSP00000482743 | Chromosome alignment-maintaining phosphoprotein 1; Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore; Zinc fingers C2H2-type | Tryptase beta 2; Belongs to the peptidase S1 family | 0.440 |
CHAMP1 | TRMT13 | ENSP00000354730 | ENSP00000359160 | Chromosome alignment-maintaining phosphoprotein 1; Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore; Zinc fingers C2H2-type | tRNA-m(4)X modification enzyme TRM13 homolog; tRNA methylase which 2’-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His) | 0.667 |
CPA3 | TPSAB1 | ENSP00000296046 | ENSP00000343577 | M14 carboxypeptidases | Tryptase alpha/beta-1; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates; Belongs to the peptidase S1 family. Tryptase subfamily | 0.888 |
CPA3 | TPSB2 | ENSP00000296046 | ENSP00000482743 | M14 carboxypeptidases | Tryptase beta 2; Belongs to the peptidase S1 family | 0.726 |
CPA4 | TPSAB1 | ENSP00000222482 | ENSP00000343577 | Carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway. Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val; Belongs to the peptidase M14 family | Tryptase alpha/beta-1; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates; Belongs to the peptidase S1 family. Tryptase subfamily | 0.643 |
CPA4 | TPSB2 | ENSP00000222482 | ENSP00000482743 | Carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway. Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val; Belongs to the peptidase M14 family | Tryptase beta 2; Belongs to the peptidase S1 family | 0.544 |
LRRC8B | C5orf22 | ENSP00000332674 | ENSP00000326879 | Volume-regulated anion channel subunit LRRC8B; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition | UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family | 0.627 |
LRRC8B | CHAMP1 | ENSP00000332674 | ENSP00000354730 | Volume-regulated anion channel subunit LRRC8B; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition | Chromosome alignment-maintaining phosphoprotein 1; Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore; Zinc fingers C2H2-type | 0.576 |
LRRC8B | PIGH | ENSP00000332674 | ENSP00000216452 | Volume-regulated anion channel subunit LRRC8B; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition | Phosphatidylinositol N-acetylglucosaminyltransferase subunit H; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis | 0.580 |