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  • 11.0 [archived version]
STRINGSTRING
TUBB2B TUBB2B CPA3 CPA3 TPSB2 TPSB2 CHAMP1 CHAMP1 TPSAB1 TPSAB1 C5orf22 C5orf22 PIGH PIGH CPA4 CPA4 TRMT13 TRMT13 LRRC8B LRRC8B SAYSD1 SAYSD1
"TPSB2" - Tryptase beta 2 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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[Homology]
Score
TPSB2Tryptase beta 2; Belongs to the peptidase S1 family (275 aa)    
Predicted Functional Partners:
CPA3
M14 carboxypeptidases (417 aa)
     
 
  0.726
TPSAB1
Tryptase alpha/beta-1; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates; Belongs to the peptidase S1 family. Tryptase subfamily (275 aa)
   
 
0.608
TRMT13
tRNA-m(4)X modification enzyme TRM13 homolog; tRNA methylase which 2’-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His) (481 aa)
           
  0.544
CPA4
Carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway. Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val; Belongs to the peptidase M14 family (421 aa)
       
 
  0.544
TUBB2B
Tubulin beta-2B chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Plays a critical role in proper axon guidance in both central and peripheral axon tracts. Implicated in neuronal migration; Tubulins (445 aa)
       
      0.524
C5orf22
UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family (442 aa)
           
  0.492
SAYSD1
SAYSVFN motif domain containing 1 (183 aa)
           
  0.473
LRRC8B
Volume-regulated anion channel subunit LRRC8B; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (803 aa)
       
 
  0.457
CHAMP1
Chromosome alignment-maintaining phosphoprotein 1; Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore; Zinc fingers C2H2-type (812 aa)
           
  0.440
PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis (188 aa)
           
  0.423
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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