PEX12 protein (human) - STRING database

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PEX12

Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins (359 aa)

Predicted Functional Partners:

PEX10

0.999

PEX2

0.998

PEX13

0.998

PEX6

0.996

PEX14

0.994

PEX7

0.994

PEX1

0.993

PEX5

0.988

PEX3

0.985

PEX26

0.980

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PEX1	PEX10	ENSP00000248633	ENSP00000288774	Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	0.991
PEX1	PEX12	ENSP00000248633	ENSP00000482609	Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes	Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins	0.993
PEX1	PEX13	ENSP00000248633	ENSP00000295030	Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes	Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins; Peroxins	0.993
PEX1	PEX14	ENSP00000248633	ENSP00000349016	Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes	Peroxisomal membrane protein PEX14; Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin; Peroxins	0.985
PEX1	PEX2	ENSP00000248633	ENSP00000349543	Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes	Peroxisome biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes; Belongs to the pex2/pex10/pex12 family	0.988
PEX1	PEX26	ENSP00000248633	ENSP00000331106	Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes	Peroxisome assembly protein 26; Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence; Peroxins	0.988
PEX1	PEX3	ENSP00000248633	ENSP00000356563	Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes	Peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes; Belongs to the peroxin-3 family	0.894
PEX1	PEX5	ENSP00000248633	ENSP00000391601	Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes	Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import	0.920
PEX1	PEX6	ENSP00000248633	ENSP00000303511	Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes	Peroxisome assembly factor 2; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes	0.982
PEX1	PEX7	ENSP00000248633	ENSP00000315680	Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes	Peroxisomal targeting signal 2 receptor; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import; Belongs to the WD repeat peroxin-7 family	0.987
PEX10	PEX1	ENSP00000288774	ENSP00000248633	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes	0.991
PEX10	PEX12	ENSP00000288774	ENSP00000482609	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins	0.999
PEX10	PEX13	ENSP00000288774	ENSP00000295030	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins; Peroxins	0.996
PEX10	PEX14	ENSP00000288774	ENSP00000349016	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	Peroxisomal membrane protein PEX14; Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin; Peroxins	0.992
PEX10	PEX2	ENSP00000288774	ENSP00000349543	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	Peroxisome biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes; Belongs to the pex2/pex10/pex12 family	0.999
PEX10	PEX26	ENSP00000288774	ENSP00000331106	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	Peroxisome assembly protein 26; Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence; Peroxins	0.980
PEX10	PEX3	ENSP00000288774	ENSP00000356563	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	Peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes; Belongs to the peroxin-3 family	0.941
PEX10	PEX5	ENSP00000288774	ENSP00000391601	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import	0.966
PEX10	PEX6	ENSP00000288774	ENSP00000303511	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	Peroxisome assembly factor 2; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes	0.995
PEX10	PEX7	ENSP00000288774	ENSP00000315680	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	Peroxisomal targeting signal 2 receptor; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import; Belongs to the WD repeat peroxin-7 family	0.996

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