| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DCAF6 | KLHDC2 | ENSP00000356814 | ENSP00000298307 | DDB1- and CUL4-associated factor 6; Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex | Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding | 0.500 |
| DCAF6 | RNF14 | ENSP00000356814 | ENSP00000378028 | DDB1- and CUL4-associated factor 6; Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex | E3 ubiquitin-protein ligase RNF14; Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription; Belongs to the RBR family. RNF14 subfamily | 0.607 |
| DCAF6 | ZNF322 | ENSP00000356814 | ENSP00000482607 | DDB1- and CUL4-associated factor 6; Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex | Zinc finger protein 322; Involved in transcriptional regulation as an activator; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.492 |
| DCAF6 | ZNHIT6 | ENSP00000356814 | ENSP00000359606 | DDB1- and CUL4-associated factor 6; Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex | Box C/D snoRNA protein 1; Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis; Belongs to the BCD1 family | 0.622 |
| FAM208B | ZNF322 | ENSP00000328426 | ENSP00000482607 | Protein FAM208B; Family with sequence similarity 208 member B; Belongs to the FAM208 family | Zinc finger protein 322; Involved in transcriptional regulation as an activator; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.473 |
| FOS | JUN | ENSP00000306245 | ENSP00000360266 | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and different [...] | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells. Binds to the USP28 promoter in colorectal cancer (CRC) cells; Basic leucine zipper proteins | 0.999 |
| FOS | ZNF322 | ENSP00000306245 | ENSP00000482607 | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and different [...] | Zinc finger protein 322; Involved in transcriptional regulation as an activator; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.463 |
| JUN | FOS | ENSP00000360266 | ENSP00000306245 | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells. Binds to the USP28 promoter in colorectal cancer (CRC) cells; Basic leucine zipper proteins | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and different [...] | 0.999 |
| JUN | ZNF322 | ENSP00000360266 | ENSP00000482607 | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells. Binds to the USP28 promoter in colorectal cancer (CRC) cells; Basic leucine zipper proteins | Zinc finger protein 322; Involved in transcriptional regulation as an activator; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.639 |
| KLHDC2 | DCAF6 | ENSP00000298307 | ENSP00000356814 | Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding | DDB1- and CUL4-associated factor 6; Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex | 0.500 |
| KLHDC2 | RNF14 | ENSP00000298307 | ENSP00000378028 | Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding | E3 ubiquitin-protein ligase RNF14; Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription; Belongs to the RBR family. RNF14 subfamily | 0.412 |
| KLHDC2 | ZNF322 | ENSP00000298307 | ENSP00000482607 | Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding | Zinc finger protein 322; Involved in transcriptional regulation as an activator; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.491 |
| KLHDC2 | ZNHIT6 | ENSP00000298307 | ENSP00000359606 | Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding | Box C/D snoRNA protein 1; Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis; Belongs to the BCD1 family | 0.465 |
| POM121L2 | ZNF322 | ENSP00000392726 | ENSP00000482607 | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family | Zinc finger protein 322; Involved in transcriptional regulation as an activator; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.574 |
| RNF14 | DCAF6 | ENSP00000378028 | ENSP00000356814 | E3 ubiquitin-protein ligase RNF14; Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription; Belongs to the RBR family. RNF14 subfamily | DDB1- and CUL4-associated factor 6; Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex | 0.607 |
| RNF14 | KLHDC2 | ENSP00000378028 | ENSP00000298307 | E3 ubiquitin-protein ligase RNF14; Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription; Belongs to the RBR family. RNF14 subfamily | Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding | 0.412 |
| RNF14 | ZNF322 | ENSP00000378028 | ENSP00000482607 | E3 ubiquitin-protein ligase RNF14; Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription; Belongs to the RBR family. RNF14 subfamily | Zinc finger protein 322; Involved in transcriptional regulation as an activator; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.473 |
| RNF14 | ZNHIT6 | ENSP00000378028 | ENSP00000359606 | E3 ubiquitin-protein ligase RNF14; Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription; Belongs to the RBR family. RNF14 subfamily | Box C/D snoRNA protein 1; Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis; Belongs to the BCD1 family | 0.591 |
| SELT | ZNF322 | ENSP00000418910 | ENSP00000482607 | Thioredoxin reductase-like selenoprotein T; Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress ans cell death. Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (By similarity). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, con [...] | Zinc finger protein 322; Involved in transcriptional regulation as an activator; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.461 |
| VRK3 | ZNF322 | ENSP00000469880 | ENSP00000482607 | Inactive serine/threonine-protein kinase VRK3; Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus | Zinc finger protein 322; Involved in transcriptional regulation as an activator; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.456 |
