node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADRB2 | SPATS2L | ENSP00000305372 | ENSP00000482515 | Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine; Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily | SPATS2-like protein; Spermatogenesis associated serine rich 2 like; Belongs to the SPATS2 family | 0.480 |
AOX1 | KCTD18 | ENSP00000363832 | ENSP00000352941 | Aldehyde oxidase; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N- methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species [...] | BTB/POZ domain-containing protein KCTD18; Potassium channel tetramerization domain containing 18 | 0.409 |
AOX1 | SPATS2L | ENSP00000363832 | ENSP00000482515 | Aldehyde oxidase; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N- methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species [...] | SPATS2-like protein; Spermatogenesis associated serine rich 2 like; Belongs to the SPATS2 family | 0.542 |
AOX1 | TYW5 | ENSP00000363832 | ENSP00000346627 | Aldehyde oxidase; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N- methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species [...] | tRNA wybutosine-synthesizing protein 5; tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3’-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes; Belongs to the TYW5 family | 0.536 |
BZW1 | C2orf47 | ENSP00000394316 | ENSP00000295079 | Basic leucine zipper and W2 domain-containing protein 1; Enhances histone H4 gene transcription but does not seem to bind DNA directly | m-AAA protease-interacting protein 1, mitochondrial; Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB) | 0.424 |
BZW1 | C2orf69 | ENSP00000394316 | ENSP00000312770 | Basic leucine zipper and W2 domain-containing protein 1; Enhances histone H4 gene transcription but does not seem to bind DNA directly | UPF0565 protein C2orf69; Chromosome 2 open reading frame 69 | 0.445 |
BZW1 | KCTD18 | ENSP00000394316 | ENSP00000352941 | Basic leucine zipper and W2 domain-containing protein 1; Enhances histone H4 gene transcription but does not seem to bind DNA directly | BTB/POZ domain-containing protein KCTD18; Potassium channel tetramerization domain containing 18 | 0.679 |
BZW1 | SPATS2L | ENSP00000394316 | ENSP00000482515 | Basic leucine zipper and W2 domain-containing protein 1; Enhances histone H4 gene transcription but does not seem to bind DNA directly | SPATS2-like protein; Spermatogenesis associated serine rich 2 like; Belongs to the SPATS2 family | 0.738 |
BZW1 | TYW5 | ENSP00000394316 | ENSP00000346627 | Basic leucine zipper and W2 domain-containing protein 1; Enhances histone H4 gene transcription but does not seem to bind DNA directly | tRNA wybutosine-synthesizing protein 5; tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3’-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes; Belongs to the TYW5 family | 0.732 |
C2orf47 | BZW1 | ENSP00000295079 | ENSP00000394316 | m-AAA protease-interacting protein 1, mitochondrial; Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB) | Basic leucine zipper and W2 domain-containing protein 1; Enhances histone H4 gene transcription but does not seem to bind DNA directly | 0.424 |
C2orf47 | C2orf69 | ENSP00000295079 | ENSP00000312770 | m-AAA protease-interacting protein 1, mitochondrial; Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB) | UPF0565 protein C2orf69; Chromosome 2 open reading frame 69 | 0.608 |
C2orf47 | FTCDNL1 | ENSP00000295079 | ENSP00000482786 | m-AAA protease-interacting protein 1, mitochondrial; Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB) | Formiminotransferase cyclodeaminase N-terminal like | 0.642 |
C2orf47 | KCTD18 | ENSP00000295079 | ENSP00000352941 | m-AAA protease-interacting protein 1, mitochondrial; Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB) | BTB/POZ domain-containing protein KCTD18; Potassium channel tetramerization domain containing 18 | 0.525 |
C2orf47 | SPATS2L | ENSP00000295079 | ENSP00000482515 | m-AAA protease-interacting protein 1, mitochondrial; Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB) | SPATS2-like protein; Spermatogenesis associated serine rich 2 like; Belongs to the SPATS2 family | 0.497 |
C2orf47 | TYW5 | ENSP00000295079 | ENSP00000346627 | m-AAA protease-interacting protein 1, mitochondrial; Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB) | tRNA wybutosine-synthesizing protein 5; tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3’-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes; Belongs to the TYW5 family | 0.556 |
C2orf69 | BZW1 | ENSP00000312770 | ENSP00000394316 | UPF0565 protein C2orf69; Chromosome 2 open reading frame 69 | Basic leucine zipper and W2 domain-containing protein 1; Enhances histone H4 gene transcription but does not seem to bind DNA directly | 0.445 |
C2orf69 | C2orf47 | ENSP00000312770 | ENSP00000295079 | UPF0565 protein C2orf69; Chromosome 2 open reading frame 69 | m-AAA protease-interacting protein 1, mitochondrial; Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB) | 0.608 |
C2orf69 | FTCDNL1 | ENSP00000312770 | ENSP00000482786 | UPF0565 protein C2orf69; Chromosome 2 open reading frame 69 | Formiminotransferase cyclodeaminase N-terminal like | 0.440 |
C2orf69 | KCTD18 | ENSP00000312770 | ENSP00000352941 | UPF0565 protein C2orf69; Chromosome 2 open reading frame 69 | BTB/POZ domain-containing protein KCTD18; Potassium channel tetramerization domain containing 18 | 0.559 |
C2orf69 | SPATS2L | ENSP00000312770 | ENSP00000482515 | UPF0565 protein C2orf69; Chromosome 2 open reading frame 69 | SPATS2-like protein; Spermatogenesis associated serine rich 2 like; Belongs to the SPATS2 family | 0.599 |