node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAP1 | IFFO1 | ENSP00000158762 | ENSP00000482285 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration; Ankyrin repeat domain containing | Intermediate filament family orphan 1; Belongs to the intermediate filament family | 0.547 |
AMOTL1 | CDADC1 | ENSP00000387739 | ENSP00000251108 | Angiomotin-like protein 1; Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus; Belongs to the angiomotin family | Cytidine and dCMP deaminase domain-containing protein 1; May play an important role in testicular development and spermatogenesis; Belongs to the cytidine and deoxycytidylate deaminase family | 0.600 |
AMOTL1 | IFFO1 | ENSP00000387739 | ENSP00000482285 | Angiomotin-like protein 1; Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus; Belongs to the angiomotin family | Intermediate filament family orphan 1; Belongs to the intermediate filament family | 0.600 |
C11orf52 | IFFO1 | ENSP00000278601 | ENSP00000482285 | Uncharacterized protein C11orf52; Chromosome 11 open reading frame 52 | Intermediate filament family orphan 1; Belongs to the intermediate filament family | 0.510 |
CDADC1 | AMOTL1 | ENSP00000251108 | ENSP00000387739 | Cytidine and dCMP deaminase domain-containing protein 1; May play an important role in testicular development and spermatogenesis; Belongs to the cytidine and deoxycytidylate deaminase family | Angiomotin-like protein 1; Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus; Belongs to the angiomotin family | 0.600 |
CDADC1 | IFFO1 | ENSP00000251108 | ENSP00000482285 | Cytidine and dCMP deaminase domain-containing protein 1; May play an important role in testicular development and spermatogenesis; Belongs to the cytidine and deoxycytidylate deaminase family | Intermediate filament family orphan 1; Belongs to the intermediate filament family | 0.600 |
DOCK5 | IFFO1 | ENSP00000276440 | ENSP00000482285 | Dedicator of cytokinesis protein 5; Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen; DOCK C2 domain containing | Intermediate filament family orphan 1; Belongs to the intermediate filament family | 0.506 |
IFFO1 | ACAP1 | ENSP00000482285 | ENSP00000158762 | Intermediate filament family orphan 1; Belongs to the intermediate filament family | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration; Ankyrin repeat domain containing | 0.547 |
IFFO1 | AMOTL1 | ENSP00000482285 | ENSP00000387739 | Intermediate filament family orphan 1; Belongs to the intermediate filament family | Angiomotin-like protein 1; Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus; Belongs to the angiomotin family | 0.600 |
IFFO1 | C11orf52 | ENSP00000482285 | ENSP00000278601 | Intermediate filament family orphan 1; Belongs to the intermediate filament family | Uncharacterized protein C11orf52; Chromosome 11 open reading frame 52 | 0.510 |
IFFO1 | CDADC1 | ENSP00000482285 | ENSP00000251108 | Intermediate filament family orphan 1; Belongs to the intermediate filament family | Cytidine and dCMP deaminase domain-containing protein 1; May play an important role in testicular development and spermatogenesis; Belongs to the cytidine and deoxycytidylate deaminase family | 0.600 |
IFFO1 | DOCK5 | ENSP00000482285 | ENSP00000276440 | Intermediate filament family orphan 1; Belongs to the intermediate filament family | Dedicator of cytokinesis protein 5; Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen; DOCK C2 domain containing | 0.506 |
IFFO1 | MARCH9 | ENSP00000482285 | ENSP00000266643 | Intermediate filament family orphan 1; Belongs to the intermediate filament family | E3 ubiquitin-protein ligase MARCH9; E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates; Membrane associated ring-CH-type fingers | 0.577 |
IFFO1 | NEK11 | ENSP00000482285 | ENSP00000372857 | Intermediate filament family orphan 1; Belongs to the intermediate filament family | Serine/threonine-protein kinase Nek11; Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation | 0.580 |
IFFO1 | RASGRP3 | ENSP00000482285 | ENSP00000384192 | Intermediate filament family orphan 1; Belongs to the intermediate filament family | Ras guanyl-releasing protein 3; Guanine nucleotide exchange factor (GEF) for Ras and Rap1; EF-hand domain containing | 0.506 |
IFFO1 | TCHP | ENSP00000482285 | ENSP00000324404 | Intermediate filament family orphan 1; Belongs to the intermediate filament family | Trichoplein keratin filament-binding protein; Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a ’capping’ or ’branching’ protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells. Is a negative regulator of ciliogenesis; Belongs to the TCHP family | 0.723 |
IFFO1 | WNK3 | ENSP00000482285 | ENSP00000346667 | Intermediate filament family orphan 1; Belongs to the intermediate filament family | Serine/threonine-protein kinase WNK3; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway. Inhibits the activity of KCNJ1 by decreasing its expression at the ce [...] | 0.538 |
MARCH9 | IFFO1 | ENSP00000266643 | ENSP00000482285 | E3 ubiquitin-protein ligase MARCH9; E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates; Membrane associated ring-CH-type fingers | Intermediate filament family orphan 1; Belongs to the intermediate filament family | 0.577 |
MARCH9 | NEK11 | ENSP00000266643 | ENSP00000372857 | E3 ubiquitin-protein ligase MARCH9; E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates; Membrane associated ring-CH-type fingers | Serine/threonine-protein kinase Nek11; Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation | 0.449 |
NEK11 | IFFO1 | ENSP00000372857 | ENSP00000482285 | Serine/threonine-protein kinase Nek11; Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation | Intermediate filament family orphan 1; Belongs to the intermediate filament family | 0.580 |