CGA protein (human) - STRING database

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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CGA

Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family (147 aa)

Predicted Functional Partners:

TSHB

0.988

FSHB

0.988

POMC

0.985

LHB

0.981

FSHR

0.967

GHRHR

0.960

LHCGR

0.960

GCG

0.958

GHRH

0.951

CRH

0.951

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CGA	CRH	ENSP00000482232	ENSP00000276571	Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family	Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Endogenous ligands	0.951
CGA	FSHB	ENSP00000482232	ENSP00000416606	Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family	Follitropin subunit beta; Stimulates development of follicle and spermatogenesis in the reproductive organs; Belongs to the glycoprotein hormones subunit beta family	0.988
CGA	FSHR	ENSP00000482232	ENSP00000384708	Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family	Follicle-stimulating hormone receptor; Receptor for follicle-stimulating hormone or follitropin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Induces cAMP production through the activation of PI3K-AKT and SRC-ERK1/2 signaling pathways; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily	0.967
CGA	GCG	ENSP00000482232	ENSP00000387662	Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family	Glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life; Belongs to the glucagon family	0.958
CGA	GHRH	ENSP00000482232	ENSP00000362716	Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family	Somatoliberin; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone; Belongs to the glucagon family	0.951
CGA	GHRHR	ENSP00000482232	ENSP00000320180	Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family	Growth hormone-releasing hormone receptor; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion; Belongs to the G-protein coupled receptor 2 family	0.960
CGA	LHB	ENSP00000482232	ENSP00000221421	Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family	Lutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids; Endogenous ligands	0.981
CGA	LHCGR	ENSP00000482232	ENSP00000294954	Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family	Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Glycoprotein hormone receptors	0.960
CGA	POMC	ENSP00000482232	ENSP00000384092	Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family	Pro-opiomelanocortin; Met-enkephalin- Endogenous opiate; Belongs to the POMC family	0.985
CGA	TSHB	ENSP00000482232	ENSP00000256592	Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family	Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism; Endogenous ligands	0.988
CRH	CGA	ENSP00000276571	ENSP00000482232	Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Endogenous ligands	Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family	0.951
CRH	FSHB	ENSP00000276571	ENSP00000416606	Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Endogenous ligands	Follitropin subunit beta; Stimulates development of follicle and spermatogenesis in the reproductive organs; Belongs to the glycoprotein hormones subunit beta family	0.908
CRH	FSHR	ENSP00000276571	ENSP00000384708	Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Endogenous ligands	Follicle-stimulating hormone receptor; Receptor for follicle-stimulating hormone or follitropin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Induces cAMP production through the activation of PI3K-AKT and SRC-ERK1/2 signaling pathways; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily	0.908
CRH	GCG	ENSP00000276571	ENSP00000387662	Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Endogenous ligands	Glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life; Belongs to the glucagon family	0.959
CRH	GHRH	ENSP00000276571	ENSP00000362716	Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Endogenous ligands	Somatoliberin; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone; Belongs to the glucagon family	0.978
CRH	GHRHR	ENSP00000276571	ENSP00000320180	Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Endogenous ligands	Growth hormone-releasing hormone receptor; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion; Belongs to the G-protein coupled receptor 2 family	0.954
CRH	LHB	ENSP00000276571	ENSP00000221421	Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Endogenous ligands	Lutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids; Endogenous ligands	0.926
CRH	LHCGR	ENSP00000276571	ENSP00000294954	Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Endogenous ligands	Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Glycoprotein hormone receptors	0.912
CRH	POMC	ENSP00000276571	ENSP00000384092	Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Endogenous ligands	Pro-opiomelanocortin; Met-enkephalin- Endogenous opiate; Belongs to the POMC family	0.997
CRH	TSHB	ENSP00000276571	ENSP00000256592	Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Endogenous ligands	Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism; Endogenous ligands	0.941

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