PLEKHA2 protein (human) - STRING database

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PLEKHA2

Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity); Pleckstrin homology domain containing (425 aa)

Predicted Functional Partners:

PTPN13

0.942

KCTD16

0.573

PLEKHG1

0.568

INPPL1

0.563

GOT1L1

0.555

PLEKHH3

0.545

HTRA4

0.538

GIPC1

0.527

TM2D2

0.516

OR2A14

0.507

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GIPC1	PLEKHA2	ENSP00000376753	ENSP00000482228	PDZ domain-containing protein GIPC1; May be involved in G protein-linked signaling; Belongs to the GIPC family	Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity); Pleckstrin homology domain containing	0.527
GOT1L1	HTRA4	ENSP00000303077	ENSP00000305919	Putative aspartate aminotransferase, cytoplasmic 2; Glutamic-oxaloacetic transaminase 1 like 1	Serine protease HTRA4; Serine protease; PDZ domain containing	0.437
GOT1L1	PLEKHA2	ENSP00000303077	ENSP00000482228	Putative aspartate aminotransferase, cytoplasmic 2; Glutamic-oxaloacetic transaminase 1 like 1	Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity); Pleckstrin homology domain containing	0.555
GOT1L1	TM2D2	ENSP00000303077	ENSP00000416050	Putative aspartate aminotransferase, cytoplasmic 2; Glutamic-oxaloacetic transaminase 1 like 1	TM2 domain containing 2	0.473
HTRA4	GOT1L1	ENSP00000305919	ENSP00000303077	Serine protease HTRA4; Serine protease; PDZ domain containing	Putative aspartate aminotransferase, cytoplasmic 2; Glutamic-oxaloacetic transaminase 1 like 1	0.437
HTRA4	PLEKHA2	ENSP00000305919	ENSP00000482228	Serine protease HTRA4; Serine protease; PDZ domain containing	Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity); Pleckstrin homology domain containing	0.538
HTRA4	TM2D2	ENSP00000305919	ENSP00000416050	Serine protease HTRA4; Serine protease; PDZ domain containing	TM2 domain containing 2	0.609
INPPL1	PLEKHA2	ENSP00000298229	ENSP00000482228	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signalin [...]	Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity); Pleckstrin homology domain containing	0.563
KCTD16	PLEKHA2	ENSP00000426548	ENSP00000482228	BTB/POZ domain-containing protein KCTD16; Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity)	Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity); Pleckstrin homology domain containing	0.573
OR2A14	PLEKHA2	ENSP00000386137	ENSP00000482228	Olfactory receptor 2A14; Odorant receptor; Olfactory receptors, family 2	Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity); Pleckstrin homology domain containing	0.507
PLEKHA2	GIPC1	ENSP00000482228	ENSP00000376753	Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity); Pleckstrin homology domain containing	PDZ domain-containing protein GIPC1; May be involved in G protein-linked signaling; Belongs to the GIPC family	0.527
PLEKHA2	GOT1L1	ENSP00000482228	ENSP00000303077	Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity); Pleckstrin homology domain containing	Putative aspartate aminotransferase, cytoplasmic 2; Glutamic-oxaloacetic transaminase 1 like 1	0.555
PLEKHA2	HTRA4	ENSP00000482228	ENSP00000305919	Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity); Pleckstrin homology domain containing	Serine protease HTRA4; Serine protease; PDZ domain containing	0.538
PLEKHA2	INPPL1	ENSP00000482228	ENSP00000298229	Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity); Pleckstrin homology domain containing	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signalin [...]	0.563
PLEKHA2	KCTD16	ENSP00000482228	ENSP00000426548	Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity); Pleckstrin homology domain containing	BTB/POZ domain-containing protein KCTD16; Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity)	0.573
PLEKHA2	OR2A14	ENSP00000482228	ENSP00000386137	Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity); Pleckstrin homology domain containing	Olfactory receptor 2A14; Odorant receptor; Olfactory receptors, family 2	0.507
PLEKHA2	PLEKHG1	ENSP00000482228	ENSP00000356297	Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity); Pleckstrin homology domain containing	Pleckstrin homology and RhoGEF domain containing G1	0.568
PLEKHA2	PLEKHH3	ENSP00000482228	ENSP00000468678	Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity); Pleckstrin homology domain containing	Pleckstrin homology, MyTH4 and FERM domain containing H3	0.545
PLEKHA2	PTPN13	ENSP00000482228	ENSP00000394794	Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity); Pleckstrin homology domain containing	Tyrosine-protein phosphatase non-receptor type 13; Tyrosine phosphatase which regulates negatively FAS- induced apoptosis and NGFR-mediated pro-apoptotic signaling. May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2; FERM domain containing	0.942
PLEKHA2	TM2D2	ENSP00000482228	ENSP00000416050	Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity); Pleckstrin homology domain containing	TM2 domain containing 2	0.516

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