| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMY2A | BCL2L12 | ENSP00000481450 | ENSP00000482218 | Pancreatic alpha-amylase; Amylase, alpha 2A | Bcl-2-like protein 12; BCL2 like 12 | 0.680 |
| BAX | BCL2L1 | ENSP00000293288 | ENSP00000302564 | Apoptosis regulator BAX; Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis; Belongs to the Bcl-2 family | Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis; Belongs to the Bcl-2 family | 0.998 |
| BAX | BCL2L12 | ENSP00000293288 | ENSP00000482218 | Apoptosis regulator BAX; Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis; Belongs to the Bcl-2 family | Bcl-2-like protein 12; BCL2 like 12 | 0.579 |
| BAX | TP53 | ENSP00000293288 | ENSP00000269305 | Apoptosis regulator BAX; Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis; Belongs to the Bcl-2 family | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in [...] | 0.984 |
| BCL2L1 | BAX | ENSP00000302564 | ENSP00000293288 | Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis; Belongs to the Bcl-2 family | Apoptosis regulator BAX; Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis; Belongs to the Bcl-2 family | 0.998 |
| BCL2L1 | BCL2L12 | ENSP00000302564 | ENSP00000482218 | Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis; Belongs to the Bcl-2 family | Bcl-2-like protein 12; BCL2 like 12 | 0.746 |
| BCL2L1 | TP53 | ENSP00000302564 | ENSP00000269305 | Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis; Belongs to the Bcl-2 family | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in [...] | 0.999 |
| BCL2L12 | AMY2A | ENSP00000482218 | ENSP00000481450 | Bcl-2-like protein 12; BCL2 like 12 | Pancreatic alpha-amylase; Amylase, alpha 2A | 0.680 |
| BCL2L12 | BAX | ENSP00000482218 | ENSP00000293288 | Bcl-2-like protein 12; BCL2 like 12 | Apoptosis regulator BAX; Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis; Belongs to the Bcl-2 family | 0.579 |
| BCL2L12 | BCL2L1 | ENSP00000482218 | ENSP00000302564 | Bcl-2-like protein 12; BCL2 like 12 | Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis; Belongs to the Bcl-2 family | 0.746 |
| BCL2L12 | KSR2 | ENSP00000482218 | ENSP00000389715 | Bcl-2-like protein 12; BCL2 like 12 | Kinase suppressor of Ras 2; Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8- mediated signaling. Acts as a negative regulator of MAP3K3- mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family | 0.556 |
| BCL2L12 | NAIF1 | ENSP00000482218 | ENSP00000362170 | Bcl-2-like protein 12; BCL2 like 12 | Nuclear apoptosis-inducing factor 1; Induces apoptosis; Belongs to the NAIF1 family | 0.628 |
| BCL2L12 | PRR12 | ENSP00000482218 | ENSP00000394510 | Bcl-2-like protein 12; BCL2 like 12 | Proline-rich protein 12; Proline rich 12 | 0.706 |
| BCL2L12 | PRRG2 | ENSP00000482218 | ENSP00000246794 | Bcl-2-like protein 12; BCL2 like 12 | Transmembrane gamma-carboxyglutamic acid protein 2; Proline rich and Gla domain containing | 0.689 |
| BCL2L12 | RIT1 | ENSP00000482218 | ENSP00000357305 | Bcl-2-like protein 12; BCL2 like 12 | GTP-binding protein Rit1; Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF- dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation; Belongs to the small GTPase superfamily. Ras family | 0.582 |
| BCL2L12 | SCAF1 | ENSP00000482218 | ENSP00000353769 | Bcl-2-like protein 12; BCL2 like 12 | Splicing factor, arginine/serine-rich 19; May function in pre-mRNA splicing | 0.707 |
| BCL2L12 | TP53 | ENSP00000482218 | ENSP00000269305 | Bcl-2-like protein 12; BCL2 like 12 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in [...] | 0.756 |
| KSR2 | BCL2L12 | ENSP00000389715 | ENSP00000482218 | Kinase suppressor of Ras 2; Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8- mediated signaling. Acts as a negative regulator of MAP3K3- mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family | Bcl-2-like protein 12; BCL2 like 12 | 0.556 |
| KSR2 | NAIF1 | ENSP00000389715 | ENSP00000362170 | Kinase suppressor of Ras 2; Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8- mediated signaling. Acts as a negative regulator of MAP3K3- mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family | Nuclear apoptosis-inducing factor 1; Induces apoptosis; Belongs to the NAIF1 family | 0.641 |
| KSR2 | RIT1 | ENSP00000389715 | ENSP00000357305 | Kinase suppressor of Ras 2; Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8- mediated signaling. Acts as a negative regulator of MAP3K3- mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family | GTP-binding protein Rit1; Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF- dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation; Belongs to the small GTPase superfamily. Ras family | 0.765 |
