FAM13C protein (human) - STRING database

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FAM13C

Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family (585 aa)

Predicted Functional Partners:

AHCYL1

0.787

CPXM2

0.748

FAM124B

0.653

GABRB3

0.589

SDAD1

0.568

GABRB2

0.562

FAM43B

0.561

PDZRN3

0.558

COL4A2

0.526

LGALSL

0.521

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHCYL1	FAM13C	ENSP00000358814	ENSP00000481854	S-adenosylhomocysteine hydrolase-like protein 1; Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5- trisphosphate competing for the common binding site and acting as endogenous ’pseudoligand’ whose inhibitory activity can be modulated by its phosphorylation status. In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5- trisphosphate-induced calcium release by interacting with I [...]	Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family	0.787
COL4A2	CPXM2	ENSP00000353654	ENSP00000241305	Collagen alpha-2(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen	Inactive carboxypeptidase-like protein X2; May be involved in cell-cell interactions; M14 carboxypeptidases	0.558
COL4A2	FAM13C	ENSP00000353654	ENSP00000481854	Collagen alpha-2(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen	Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family	0.526
CPXM2	COL4A2	ENSP00000241305	ENSP00000353654	Inactive carboxypeptidase-like protein X2; May be involved in cell-cell interactions; M14 carboxypeptidases	Collagen alpha-2(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen	0.558
CPXM2	FAM13C	ENSP00000241305	ENSP00000481854	Inactive carboxypeptidase-like protein X2; May be involved in cell-cell interactions; M14 carboxypeptidases	Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family	0.748
CPXM2	GABRB2	ENSP00000241305	ENSP00000274547	Inactive carboxypeptidase-like protein X2; May be involved in cell-cell interactions; M14 carboxypeptidases	Gamma-aminobutyric acid receptor subunit beta-2; Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel; Gamma-aminobutyric acid type A receptor subunits	0.426
CPXM2	GABRB3	ENSP00000241305	ENSP00000308725	Inactive carboxypeptidase-like protein X2; May be involved in cell-cell interactions; M14 carboxypeptidases	Gamma-aminobutyric acid receptor subunit beta-3; Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB3 sub-subfamily	0.497
FAM124B	FAM13C	ENSP00000386895	ENSP00000481854	Protein FAM124B; Family with sequence similarity 124 member B; Belongs to the FAM124 family	Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family	0.653
FAM13C	AHCYL1	ENSP00000481854	ENSP00000358814	Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family	S-adenosylhomocysteine hydrolase-like protein 1; Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5- trisphosphate competing for the common binding site and acting as endogenous ’pseudoligand’ whose inhibitory activity can be modulated by its phosphorylation status. In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5- trisphosphate-induced calcium release by interacting with I [...]	0.787
FAM13C	COL4A2	ENSP00000481854	ENSP00000353654	Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family	Collagen alpha-2(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen	0.526
FAM13C	CPXM2	ENSP00000481854	ENSP00000241305	Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family	Inactive carboxypeptidase-like protein X2; May be involved in cell-cell interactions; M14 carboxypeptidases	0.748
FAM13C	FAM124B	ENSP00000481854	ENSP00000386895	Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family	Protein FAM124B; Family with sequence similarity 124 member B; Belongs to the FAM124 family	0.653
FAM13C	FAM43B	ENSP00000481854	ENSP00000331397	Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family	Protein FAM43B; Family with sequence similarity 43 member B; Belongs to the FAM43 family	0.561
FAM13C	GABRB2	ENSP00000481854	ENSP00000274547	Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family	Gamma-aminobutyric acid receptor subunit beta-2; Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel; Gamma-aminobutyric acid type A receptor subunits	0.562
FAM13C	GABRB3	ENSP00000481854	ENSP00000308725	Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family	Gamma-aminobutyric acid receptor subunit beta-3; Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB3 sub-subfamily	0.589
FAM13C	LGALSL	ENSP00000481854	ENSP00000238875	Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family	Galectin-related protein; Does not bind lactose, and may not bind carbohydrates	0.521
FAM13C	PDZRN3	ENSP00000481854	ENSP00000263666	Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family	E3 ubiquitin-protein ligase PDZRN3; E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation; PDZ domain containing	0.558
FAM13C	SDAD1	ENSP00000481854	ENSP00000348596	Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family	Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family	0.568
FAM43B	FAM13C	ENSP00000331397	ENSP00000481854	Protein FAM43B; Family with sequence similarity 43 member B; Belongs to the FAM43 family	Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family	0.561
GABRB2	CPXM2	ENSP00000274547	ENSP00000241305	Gamma-aminobutyric acid receptor subunit beta-2; Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel; Gamma-aminobutyric acid type A receptor subunits	Inactive carboxypeptidase-like protein X2; May be involved in cell-cell interactions; M14 carboxypeptidases	0.426

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