node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATF2 | C18orf25 | ENSP00000264110 | ENSP00000481626 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti- apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5’-TGACGTCA-3’) or to AP-1 (activator protein 1) consensus sequences (5’-TGACTCA-3’). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cy [...] | Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25 | 0.547 |
C18orf25 | ATF2 | ENSP00000481626 | ENSP00000264110 | Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti- apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5’-TGACGTCA-3’) or to AP-1 (activator protein 1) consensus sequences (5’-TGACTCA-3’). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cy [...] | 0.547 |
C18orf25 | CSNK2A2 | ENSP00000481626 | ENSP00000262506 | Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25 | Casein kinase II subunit alpha; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoin [...] | 0.516 |
C18orf25 | RNF165 | ENSP00000481626 | ENSP00000269439 | Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25 | E3 ubiquitin-protein ligase RNF165; E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL; Belongs to the Arkadia family | 0.685 |
C18orf25 | RNF38 | ENSP00000481626 | ENSP00000259605 | Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25 | E3 ubiquitin-protein ligase RNF38; Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme; Ring finger proteins | 0.457 |
C18orf25 | SUMO1 | ENSP00000481626 | ENSP00000376077 | Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25 | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instan [...] | 0.711 |
C18orf25 | TMEM200C | ENSP00000481626 | ENSP00000463375 | Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25 | Transmembrane protein 200C | 0.510 |
C18orf25 | TP53BP1 | ENSP00000481626 | ENSP00000371475 | Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25 | TP53-binding protein 1; Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs si [...] | 0.673 |
C18orf25 | VSX2 | ENSP00000481626 | ENSP00000261980 | Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25 | Visual system homeobox 2; Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity); Belongs to the paired homeobox family | 0.735 |
C18orf25 | ZNF618 | ENSP00000481626 | ENSP00000288466 | Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25 | Zinc finger protein 618; Zinc fingers C2H2-type | 0.472 |
C18orf25 | ZRANB2 | ENSP00000481626 | ENSP00000359958 | Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25 | Zinc finger Ran-binding domain-containing protein 2; Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5’- splice site selection; Zinc fingers RANBP2-type | 0.588 |
CSNK2A2 | C18orf25 | ENSP00000262506 | ENSP00000481626 | Casein kinase II subunit alpha; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoin [...] | Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25 | 0.516 |
RNF165 | C18orf25 | ENSP00000269439 | ENSP00000481626 | E3 ubiquitin-protein ligase RNF165; E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL; Belongs to the Arkadia family | Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25 | 0.685 |
RNF165 | TMEM200C | ENSP00000269439 | ENSP00000463375 | E3 ubiquitin-protein ligase RNF165; E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL; Belongs to the Arkadia family | Transmembrane protein 200C | 0.520 |
RNF38 | C18orf25 | ENSP00000259605 | ENSP00000481626 | E3 ubiquitin-protein ligase RNF38; Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme; Ring finger proteins | Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25 | 0.457 |
RNF38 | ZNF618 | ENSP00000259605 | ENSP00000288466 | E3 ubiquitin-protein ligase RNF38; Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme; Ring finger proteins | Zinc finger protein 618; Zinc fingers C2H2-type | 0.410 |
SUMO1 | C18orf25 | ENSP00000376077 | ENSP00000481626 | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instan [...] | Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25 | 0.711 |
SUMO1 | TP53BP1 | ENSP00000376077 | ENSP00000371475 | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instan [...] | TP53-binding protein 1; Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs si [...] | 0.978 |
TMEM200C | C18orf25 | ENSP00000463375 | ENSP00000481626 | Transmembrane protein 200C | Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25 | 0.510 |
TMEM200C | RNF165 | ENSP00000463375 | ENSP00000269439 | Transmembrane protein 200C | E3 ubiquitin-protein ligase RNF165; E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL; Belongs to the Arkadia family | 0.520 |