DDX24 protein (human) - STRING database

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DDX24

ATP-dependent RNA helicase DDX24; ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily (859 aa)

Predicted Functional Partners:

NIFK

0.995

EBNA1BP2

0.993

NOP2

0.993

NOC3L

0.993

BRIX1

0.989

DDX56

0.988

KIAA0020

0.987

NOC2L

0.986

GTPBP4

0.984

PES1

0.983

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRIX1	DDX24	ENSP00000338862	ENSP00000481495	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	ATP-dependent RNA helicase DDX24; ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily	0.989
BRIX1	DDX56	ENSP00000338862	ENSP00000258772	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	Probable ATP-dependent RNA helicase DDX56; May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity; Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily	0.990
BRIX1	EBNA1BP2	ENSP00000338862	ENSP00000407323	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA; Belongs to the EBP2 family	0.998
BRIX1	GTPBP4	ENSP00000338862	ENSP00000354040	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily	0.986
BRIX1	KIAA0020	ENSP00000338862	ENSP00000380982	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	Pumilio homolog 3; Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells (By similarity)	0.982
BRIX1	NIFK	ENSP00000338862	ENSP00000285814	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	Nucleolar protein interacting with the FHA domain of MKI67; RNA binding motif containing	0.998
BRIX1	NOC2L	ENSP00000338862	ENSP00000317992	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	Nucleolar complex protein 2 homolog; Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter; Armadillo-like helical domain containing	0.954
BRIX1	NOC3L	ENSP00000338862	ENSP00000360412	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	Nucleolar complex protein 3 homolog; May be required for adipogenesis; Armadillo-like helical domain containing	0.997
BRIX1	NOP2	ENSP00000338862	ENSP00000371858	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase; Involved in ribosomal large subunit assembly. S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family	0.994
BRIX1	PES1	ENSP00000338862	ENSP00000346725	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family	0.993
DDX24	BRIX1	ENSP00000481495	ENSP00000338862	ATP-dependent RNA helicase DDX24; ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	0.989
DDX24	DDX56	ENSP00000481495	ENSP00000258772	ATP-dependent RNA helicase DDX24; ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily	Probable ATP-dependent RNA helicase DDX56; May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity; Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily	0.988
DDX24	EBNA1BP2	ENSP00000481495	ENSP00000407323	ATP-dependent RNA helicase DDX24; ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily	Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA; Belongs to the EBP2 family	0.993
DDX24	GTPBP4	ENSP00000481495	ENSP00000354040	ATP-dependent RNA helicase DDX24; ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily	0.984
DDX24	KIAA0020	ENSP00000481495	ENSP00000380982	ATP-dependent RNA helicase DDX24; ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily	Pumilio homolog 3; Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells (By similarity)	0.987
DDX24	NIFK	ENSP00000481495	ENSP00000285814	ATP-dependent RNA helicase DDX24; ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily	Nucleolar protein interacting with the FHA domain of MKI67; RNA binding motif containing	0.995
DDX24	NOC2L	ENSP00000481495	ENSP00000317992	ATP-dependent RNA helicase DDX24; ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily	Nucleolar complex protein 2 homolog; Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter; Armadillo-like helical domain containing	0.986
DDX24	NOC3L	ENSP00000481495	ENSP00000360412	ATP-dependent RNA helicase DDX24; ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily	Nucleolar complex protein 3 homolog; May be required for adipogenesis; Armadillo-like helical domain containing	0.993
DDX24	NOP2	ENSP00000481495	ENSP00000371858	ATP-dependent RNA helicase DDX24; ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily	Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase; Involved in ribosomal large subunit assembly. S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family	0.993
DDX24	PES1	ENSP00000481495	ENSP00000346725	ATP-dependent RNA helicase DDX24; ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family	0.983

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