node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGL | AMY2A | ENSP00000294724 | ENSP00000481450 | Glycogen debranching enzyme; Multifunctional enzyme acting as 1,4-alpha-D-glucan-1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6- glucosidase in glycogen degradation; Belongs to the glycogen debranching enzyme family | Pancreatic alpha-amylase; Amylase, alpha 2A | 0.811 |
AGL | AMY2B | ENSP00000294724 | ENSP00000354610 | Glycogen debranching enzyme; Multifunctional enzyme acting as 1,4-alpha-D-glucan-1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6- glucosidase in glycogen degradation; Belongs to the glycogen debranching enzyme family | Amylase, alpha 2B; Belongs to the glycosyl hydrolase 13 family | 0.836 |
AGL | GAA | ENSP00000294724 | ENSP00000305692 | Glycogen debranching enzyme; Multifunctional enzyme acting as 1,4-alpha-D-glucan-1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6- glucosidase in glycogen degradation; Belongs to the glycogen debranching enzyme family | Lysosomal alpha-glucosidase; Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans | 0.473 |
AGL | GBE1 | ENSP00000294724 | ENSP00000410833 | Glycogen debranching enzyme; Multifunctional enzyme acting as 1,4-alpha-D-glucan-1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6- glucosidase in glycogen degradation; Belongs to the glycogen debranching enzyme family | 1,4-alpha-glucan-branching enzyme; Required for normal glycogen accumulation. The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule (Probable); Belongs to the glycosyl hydrolase 13 family. GlgB subfamily | 0.998 |
AGL | LOC93432 | ENSP00000294724 | ENSP00000447431 | Glycogen debranching enzyme; Multifunctional enzyme acting as 1,4-alpha-D-glucan-1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6- glucosidase in glycogen degradation; Belongs to the glycogen debranching enzyme family | Probable maltase-glucoamylase 2; Homo sapiens maltase-glucoamylase (alpha-glucosidase) (LOC93432), mRNA | 0.939 |
AGL | MGAM | ENSP00000294724 | ENSP00000447378 | Glycogen debranching enzyme; Multifunctional enzyme acting as 1,4-alpha-D-glucan-1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6- glucosidase in glycogen degradation; Belongs to the glycogen debranching enzyme family | Maltase-glucoamylase, intestinal; May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing | 0.952 |
AGL | PYGB | ENSP00000294724 | ENSP00000216962 | Glycogen debranching enzyme; Multifunctional enzyme acting as 1,4-alpha-D-glucan-1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6- glucosidase in glycogen degradation; Belongs to the glycogen debranching enzyme family | Glycogen phosphorylase, brain form; Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties | 0.992 |
AGL | PYGL | ENSP00000294724 | ENSP00000216392 | Glycogen debranching enzyme; Multifunctional enzyme acting as 1,4-alpha-D-glucan-1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6- glucosidase in glycogen degradation; Belongs to the glycogen debranching enzyme family | Glycogen phosphorylase, liver form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties | 0.992 |
AGL | SI | ENSP00000294724 | ENSP00000264382 | Glycogen debranching enzyme; Multifunctional enzyme acting as 1,4-alpha-D-glucan-1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6- glucosidase in glycogen degradation; Belongs to the glycogen debranching enzyme family | Sucrase-isomaltase, intestinal; Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides; Belongs to the glycosyl hydrolase 31 family | 0.627 |
AMY2A | AGL | ENSP00000481450 | ENSP00000294724 | Pancreatic alpha-amylase; Amylase, alpha 2A | Glycogen debranching enzyme; Multifunctional enzyme acting as 1,4-alpha-D-glucan-1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6- glucosidase in glycogen degradation; Belongs to the glycogen debranching enzyme family | 0.811 |
AMY2A | AMY2B | ENSP00000481450 | ENSP00000354610 | Pancreatic alpha-amylase; Amylase, alpha 2A | Amylase, alpha 2B; Belongs to the glycosyl hydrolase 13 family | 0.806 |
AMY2A | GAA | ENSP00000481450 | ENSP00000305692 | Pancreatic alpha-amylase; Amylase, alpha 2A | Lysosomal alpha-glucosidase; Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans | 0.860 |
AMY2A | GANC | ENSP00000481450 | ENSP00000326227 | Pancreatic alpha-amylase; Amylase, alpha 2A | Neutral alpha-glucosidase C; Has alpha-glucosidase activity | 0.909 |
AMY2A | GBE1 | ENSP00000481450 | ENSP00000410833 | Pancreatic alpha-amylase; Amylase, alpha 2A | 1,4-alpha-glucan-branching enzyme; Required for normal glycogen accumulation. The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule (Probable); Belongs to the glycosyl hydrolase 13 family. GlgB subfamily | 0.932 |
AMY2A | LOC93432 | ENSP00000481450 | ENSP00000447431 | Pancreatic alpha-amylase; Amylase, alpha 2A | Probable maltase-glucoamylase 2; Homo sapiens maltase-glucoamylase (alpha-glucosidase) (LOC93432), mRNA | 0.980 |
AMY2A | MGAM | ENSP00000481450 | ENSP00000447378 | Pancreatic alpha-amylase; Amylase, alpha 2A | Maltase-glucoamylase, intestinal; May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing | 0.971 |
AMY2A | PYGB | ENSP00000481450 | ENSP00000216962 | Pancreatic alpha-amylase; Amylase, alpha 2A | Glycogen phosphorylase, brain form; Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties | 0.808 |
AMY2A | PYGL | ENSP00000481450 | ENSP00000216392 | Pancreatic alpha-amylase; Amylase, alpha 2A | Glycogen phosphorylase, liver form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties | 0.815 |
AMY2A | SI | ENSP00000481450 | ENSP00000264382 | Pancreatic alpha-amylase; Amylase, alpha 2A | Sucrase-isomaltase, intestinal; Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides; Belongs to the glycosyl hydrolase 31 family | 0.971 |
AMY2B | AGL | ENSP00000354610 | ENSP00000294724 | Amylase, alpha 2B; Belongs to the glycosyl hydrolase 13 family | Glycogen debranching enzyme; Multifunctional enzyme acting as 1,4-alpha-D-glucan-1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6- glucosidase in glycogen degradation; Belongs to the glycogen debranching enzyme family | 0.836 |