| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDYL | RPL23A | ENSP00000380718 | ENSP00000389103 | Chromodomain Y-like protein; Isoform 2- Chromatin reader protein that recognizes and binds histone H3 trimethylated at ’Lys-9’, dimethylated at ’Lys- 27’ and trimethylated at ’Lys-27’ (H3K9me3, H3K27me2 and H3K27me3, respectively). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape. Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing h [...] | 60S ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA; Belongs to the universal ribosomal protein uL23 family | 0.660 |
| CDYL | UBE2D3 | ENSP00000380718 | ENSP00000349722 | Chromodomain Y-like protein; Isoform 2- Chromatin reader protein that recognizes and binds histone H3 trimethylated at ’Lys-9’, dimethylated at ’Lys- 27’ and trimethylated at ’Lys-27’ (H3K9me3, H3K27me2 and H3K27me3, respectively). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape. Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing h [...] | Ubiquitin conjugating enzyme E2 D3; Belongs to the ubiquitin-conjugating enzyme family | 0.470 |
| CDYL | ZNF280A | ENSP00000380718 | ENSP00000302855 | Chromodomain Y-like protein; Isoform 2- Chromatin reader protein that recognizes and binds histone H3 trimethylated at ’Lys-9’, dimethylated at ’Lys- 27’ and trimethylated at ’Lys-27’ (H3K9me3, H3K27me2 and H3K27me3, respectively). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape. Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing h [...] | Zinc finger protein 280A; May function as a transcription factor | 0.717 |
| CDYL | ZNF280B | ENSP00000380718 | ENSP00000480958 | Chromodomain Y-like protein; Isoform 2- Chromatin reader protein that recognizes and binds histone H3 trimethylated at ’Lys-9’, dimethylated at ’Lys- 27’ and trimethylated at ’Lys-27’ (H3K9me3, H3K27me2 and H3K27me3, respectively). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape. Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing h [...] | Zinc finger protein 280B; May function as a transcription factor | 0.770 |
| CINP | ZNF280B | ENSP00000216756 | ENSP00000480958 | Cyclin-dependent kinase 2-interacting protein; Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling; Belongs to the CINP family | Zinc finger protein 280B; May function as a transcription factor | 0.588 |
| DYNC1LI1 | PRAME | ENSP00000273130 | ENSP00000445675 | Cytoplasmic dynein 1 light intermediate chain 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkp [...] | Melanoma antigen preferentially expressed in tumors; Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis; PRAME family | 0.506 |
| DYNC1LI1 | SETD4 | ENSP00000273130 | ENSP00000382163 | Cytoplasmic dynein 1 light intermediate chain 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkp [...] | SET domain containing 4 | 0.694 |
| DYNC1LI1 | ZNF280B | ENSP00000273130 | ENSP00000480958 | Cytoplasmic dynein 1 light intermediate chain 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkp [...] | Zinc finger protein 280B; May function as a transcription factor | 0.643 |
| POM121L1P | PRAME | ENSP00000481613 | ENSP00000445675 | annotation not available | Melanoma antigen preferentially expressed in tumors; Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis; PRAME family | 0.442 |
| POM121L1P | ZNF280A | ENSP00000481613 | ENSP00000302855 | annotation not available | Zinc finger protein 280A; May function as a transcription factor | 0.679 |
| POM121L1P | ZNF280B | ENSP00000481613 | ENSP00000480958 | annotation not available | Zinc finger protein 280B; May function as a transcription factor | 0.669 |
| PRAME | DYNC1LI1 | ENSP00000445675 | ENSP00000273130 | Melanoma antigen preferentially expressed in tumors; Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis; PRAME family | Cytoplasmic dynein 1 light intermediate chain 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkp [...] | 0.506 |
| PRAME | POM121L1P | ENSP00000445675 | ENSP00000481613 | Melanoma antigen preferentially expressed in tumors; Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis; PRAME family | annotation not available | 0.442 |
| PRAME | SETD4 | ENSP00000445675 | ENSP00000382163 | Melanoma antigen preferentially expressed in tumors; Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis; PRAME family | SET domain containing 4 | 0.459 |
| PRAME | ZNF280A | ENSP00000445675 | ENSP00000302855 | Melanoma antigen preferentially expressed in tumors; Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis; PRAME family | Zinc finger protein 280A; May function as a transcription factor | 0.760 |
| PRAME | ZNF280B | ENSP00000445675 | ENSP00000480958 | Melanoma antigen preferentially expressed in tumors; Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis; PRAME family | Zinc finger protein 280B; May function as a transcription factor | 0.694 |
| RPL23A | CDYL | ENSP00000389103 | ENSP00000380718 | 60S ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA; Belongs to the universal ribosomal protein uL23 family | Chromodomain Y-like protein; Isoform 2- Chromatin reader protein that recognizes and binds histone H3 trimethylated at ’Lys-9’, dimethylated at ’Lys- 27’ and trimethylated at ’Lys-27’ (H3K9me3, H3K27me2 and H3K27me3, respectively). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape. Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing h [...] | 0.660 |
| RPL23A | UBE2D3 | ENSP00000389103 | ENSP00000349722 | 60S ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA; Belongs to the universal ribosomal protein uL23 family | Ubiquitin conjugating enzyme E2 D3; Belongs to the ubiquitin-conjugating enzyme family | 0.644 |
| RPL23A | ZNF280A | ENSP00000389103 | ENSP00000302855 | 60S ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA; Belongs to the universal ribosomal protein uL23 family | Zinc finger protein 280A; May function as a transcription factor | 0.649 |
| RPL23A | ZNF280B | ENSP00000389103 | ENSP00000480958 | 60S ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA; Belongs to the universal ribosomal protein uL23 family | Zinc finger protein 280B; May function as a transcription factor | 0.695 |
