SRRM3 protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SRRM3

Serine/arginine repetitive matrix 3; Belongs to the CWC21 family (653 aa)

Predicted Functional Partners:

BUD13

0.864

CDC5L

0.860

EFTUD2

0.846

SYF2

0.839

PRPF8

0.838

CWC15

0.833

BUD31

0.822

DHX38

0.818

SNRNP200

0.817

PLRG1

0.816

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BUD13	BUD31	ENSP00000260210	ENSP00000386023	BUD13 homolog; Spliceosomal P complex; Belongs to the CWC26 family	Protein BUD31 homolog; Spliceosomal Bact complex	0.850
BUD13	CDC5L	ENSP00000260210	ENSP00000360532	BUD13 homolog; Spliceosomal P complex; Belongs to the CWC26 family	Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing	0.924
BUD13	CWC15	ENSP00000260210	ENSP00000475615	BUD13 homolog; Spliceosomal P complex; Belongs to the CWC26 family	Spliceosome-associated protein CWC15 homolog; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing	0.721
BUD13	DHX38	ENSP00000260210	ENSP00000268482	BUD13 homolog; Spliceosomal P complex; Belongs to the CWC26 family	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; Probable ATP-binding RNA helicase involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily	0.745
BUD13	EFTUD2	ENSP00000260210	ENSP00000392094	BUD13 homolog; Spliceosomal P complex; Belongs to the CWC26 family	116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily	0.884
BUD13	PLRG1	ENSP00000260210	ENSP00000424417	BUD13 homolog; Spliceosomal P complex; Belongs to the CWC26 family	Pleiotropic regulator 1; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing	0.768
BUD13	PRPF8	ENSP00000260210	ENSP00000460348	BUD13 homolog; Spliceosomal P complex; Belongs to the CWC26 family	Pre-mRNA-processing-splicing factor 8; Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site	0.702
BUD13	SNRNP200	ENSP00000260210	ENSP00000317123	BUD13 homolog; Spliceosomal P complex; Belongs to the CWC26 family	U5 small nuclear ribonucleoprotein 200 kDa helicase; RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome	0.795
BUD13	SRRM3	ENSP00000260210	ENSP00000480851	BUD13 homolog; Spliceosomal P complex; Belongs to the CWC26 family	Serine/arginine repetitive matrix 3; Belongs to the CWC21 family	0.864
BUD13	SYF2	ENSP00000260210	ENSP00000236273	BUD13 homolog; Spliceosomal P complex; Belongs to the CWC26 family	Pre-mRNA-splicing factor SYF2; May be involved in pre-mRNA splicing; Belongs to the SYF2 family	0.848
BUD31	BUD13	ENSP00000386023	ENSP00000260210	Protein BUD31 homolog; Spliceosomal Bact complex	BUD13 homolog; Spliceosomal P complex; Belongs to the CWC26 family	0.850
BUD31	CDC5L	ENSP00000386023	ENSP00000360532	Protein BUD31 homolog; Spliceosomal Bact complex	Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing	0.998
BUD31	CWC15	ENSP00000386023	ENSP00000475615	Protein BUD31 homolog; Spliceosomal Bact complex	Spliceosome-associated protein CWC15 homolog; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing	0.998
BUD31	DHX38	ENSP00000386023	ENSP00000268482	Protein BUD31 homolog; Spliceosomal Bact complex	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; Probable ATP-binding RNA helicase involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily	0.987
BUD31	EFTUD2	ENSP00000386023	ENSP00000392094	Protein BUD31 homolog; Spliceosomal Bact complex	116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily	0.999
BUD31	PLRG1	ENSP00000386023	ENSP00000424417	Protein BUD31 homolog; Spliceosomal Bact complex	Pleiotropic regulator 1; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing	0.998
BUD31	PRPF8	ENSP00000386023	ENSP00000460348	Protein BUD31 homolog; Spliceosomal Bact complex	Pre-mRNA-processing-splicing factor 8; Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site	0.996
BUD31	SNRNP200	ENSP00000386023	ENSP00000317123	Protein BUD31 homolog; Spliceosomal Bact complex	U5 small nuclear ribonucleoprotein 200 kDa helicase; RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome	0.998
BUD31	SRRM3	ENSP00000386023	ENSP00000480851	Protein BUD31 homolog; Spliceosomal Bact complex	Serine/arginine repetitive matrix 3; Belongs to the CWC21 family	0.822
BUD31	SYF2	ENSP00000386023	ENSP00000236273	Protein BUD31 homolog; Spliceosomal Bact complex	Pre-mRNA-splicing factor SYF2; May be involved in pre-mRNA splicing; Belongs to the SYF2 family	0.998

page 1 of 6

Network

Fusion

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Neighborhood

© STRING Consortium 2020

Credits

Access

Info

About