node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCL2L13 | BCL2L14 | ENSP00000480836 | ENSP00000309132 | Bcl-2-like protein 13; May promote the activation of caspase-3 and apoptosis; BCL2 family | Apoptosis facilitator Bcl-2-like protein 14; Plays a role in apoptosis; Belongs to the Bcl-2 family | 0.610 |
BCL2L13 | BNIP3 | ENSP00000480836 | ENSP00000357625 | Bcl-2-like protein 13; May promote the activation of caspase-3 and apoptosis; BCL2 family | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP- in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer [...] | 0.604 |
BCL2L13 | CHKA | ENSP00000480836 | ENSP00000265689 | Bcl-2-like protein 13; May promote the activation of caspase-3 and apoptosis; BCL2 family | Choline kinase alpha; Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline | 0.632 |
BCL2L13 | CNEP1R1 | ENSP00000480836 | ENSP00000405635 | Bcl-2-like protein 13; May promote the activation of caspase-3 and apoptosis; BCL2 family | CTD nuclear envelope phosphatase 1 regulatory subunit 1 | 0.678 |
BCL2L13 | FAM57A | ENSP00000480836 | ENSP00000312017 | Bcl-2-like protein 13; May promote the activation of caspase-3 and apoptosis; BCL2 family | Protein FAM57A; Family with sequence similarity 57 member A; TLC domain containing | 0.612 |
BCL2L13 | FUNDC1 | ENSP00000480836 | ENSP00000367284 | Bcl-2-like protein 13; May promote the activation of caspase-3 and apoptosis; BCL2 family | FUN14 domain-containing protein 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control | 0.588 |
BCL2L13 | GABARAP | ENSP00000480836 | ENSP00000306866 | Bcl-2-like protein 13; May promote the activation of caspase-3 and apoptosis; BCL2 family | Gamma-aminobutyric acid receptor-associated protein; Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation; Belongs to the ATG8 family | 0.841 |
BCL2L13 | GABARAPL1 | ENSP00000480836 | ENSP00000266458 | Bcl-2-like protein 13; May promote the activation of caspase-3 and apoptosis; BCL2 family | Gamma-aminobutyric acid receptor-associated protein-like 1; Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation; Belongs to the ATG8 family | 0.855 |
BCL2L13 | GABARAPL2 | ENSP00000480836 | ENSP00000037243 | Bcl-2-like protein 13; May promote the activation of caspase-3 and apoptosis; BCL2 family | Gamma-aminobutyric acid receptor-associated protein-like 2; Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved [...] | 0.884 |
BCL2L13 | PLN | ENSP00000480836 | ENSP00000350132 | Bcl-2-like protein 13; May promote the activation of caspase-3 and apoptosis; BCL2 family | Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation; Belongs to the phospholamban family | 0.539 |
BCL2L14 | BCL2L13 | ENSP00000309132 | ENSP00000480836 | Apoptosis facilitator Bcl-2-like protein 14; Plays a role in apoptosis; Belongs to the Bcl-2 family | Bcl-2-like protein 13; May promote the activation of caspase-3 and apoptosis; BCL2 family | 0.610 |
BNIP3 | BCL2L13 | ENSP00000357625 | ENSP00000480836 | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP- in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer [...] | Bcl-2-like protein 13; May promote the activation of caspase-3 and apoptosis; BCL2 family | 0.604 |
BNIP3 | FUNDC1 | ENSP00000357625 | ENSP00000367284 | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP- in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer [...] | FUN14 domain-containing protein 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control | 0.714 |
BNIP3 | GABARAP | ENSP00000357625 | ENSP00000306866 | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP- in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer [...] | Gamma-aminobutyric acid receptor-associated protein; Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation; Belongs to the ATG8 family | 0.929 |
BNIP3 | GABARAPL1 | ENSP00000357625 | ENSP00000266458 | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP- in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer [...] | Gamma-aminobutyric acid receptor-associated protein-like 1; Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation; Belongs to the ATG8 family | 0.943 |
BNIP3 | GABARAPL2 | ENSP00000357625 | ENSP00000037243 | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP- in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer [...] | Gamma-aminobutyric acid receptor-associated protein-like 2; Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved [...] | 0.924 |
CHKA | BCL2L13 | ENSP00000265689 | ENSP00000480836 | Choline kinase alpha; Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline | Bcl-2-like protein 13; May promote the activation of caspase-3 and apoptosis; BCL2 family | 0.632 |
CNEP1R1 | BCL2L13 | ENSP00000405635 | ENSP00000480836 | CTD nuclear envelope phosphatase 1 regulatory subunit 1 | Bcl-2-like protein 13; May promote the activation of caspase-3 and apoptosis; BCL2 family | 0.678 |
FAM57A | BCL2L13 | ENSP00000312017 | ENSP00000480836 | Protein FAM57A; Family with sequence similarity 57 member A; TLC domain containing | Bcl-2-like protein 13; May promote the activation of caspase-3 and apoptosis; BCL2 family | 0.612 |
FUNDC1 | BCL2L13 | ENSP00000367284 | ENSP00000480836 | FUN14 domain-containing protein 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control | Bcl-2-like protein 13; May promote the activation of caspase-3 and apoptosis; BCL2 family | 0.588 |