PKIB protein (human) - STRING database

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PKIB

cAMP-dependent protein kinase inhibitor beta; Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains (85 aa)

Predicted Functional Partners:

MPPED1

0.644

SLAIN2

0.627

AKAP14

0.608

PKIG

0.576

CALML5

0.549

AKAP4

0.485

TBATA

0.478

NUDCD2

0.457

GREB1

0.445

ANKRD32

0.433

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKAP14	AKAP4	ENSP00000360485	ENSP00000351327	A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins	A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; A-kinase anchoring proteins	0.860
AKAP14	MPPED1	ENSP00000360485	ENSP00000388137	A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins	Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro)	0.660
AKAP14	PKIB	ENSP00000360485	ENSP00000480824	A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins	cAMP-dependent protein kinase inhibitor beta; Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains	0.608
AKAP14	SLAIN2	ENSP00000360485	ENSP00000264313	A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins	SLAIN motif-containing protein 2; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase	0.634
AKAP14	TBATA	ENSP00000360485	ENSP00000299290	A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins	Protein TBATA; May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function	0.515
AKAP4	AKAP14	ENSP00000351327	ENSP00000360485	A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; A-kinase anchoring proteins	A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins	0.860
AKAP4	MPPED1	ENSP00000351327	ENSP00000388137	A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; A-kinase anchoring proteins	Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro)	0.515
AKAP4	PKIB	ENSP00000351327	ENSP00000480824	A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; A-kinase anchoring proteins	cAMP-dependent protein kinase inhibitor beta; Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains	0.485
AKAP4	SLAIN2	ENSP00000351327	ENSP00000264313	A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; A-kinase anchoring proteins	SLAIN motif-containing protein 2; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase	0.506
AKAP4	TBATA	ENSP00000351327	ENSP00000299290	A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; A-kinase anchoring proteins	Protein TBATA; May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function	0.411
ANKRD32	PKIB	ENSP00000265140	ENSP00000480824	SMC5-SMC6 complex localization factor protein 1; Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication- coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks. Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions	cAMP-dependent protein kinase inhibitor beta; Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains	0.433
CALML5	PKIB	ENSP00000369689	ENSP00000480824	Calmodulin-like protein 5; Binds calcium. May be involved in terminal differentiation of keratinocytes; EF-hand domain containing	cAMP-dependent protein kinase inhibitor beta; Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains	0.549
GREB1	PKIB	ENSP00000370896	ENSP00000480824	Protein GREB1; May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers	cAMP-dependent protein kinase inhibitor beta; Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains	0.445
MPPED1	AKAP14	ENSP00000388137	ENSP00000360485	Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro)	A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins	0.660
MPPED1	AKAP4	ENSP00000388137	ENSP00000351327	Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro)	A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; A-kinase anchoring proteins	0.515
MPPED1	PKIB	ENSP00000388137	ENSP00000480824	Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro)	cAMP-dependent protein kinase inhibitor beta; Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains	0.644
MPPED1	SLAIN2	ENSP00000388137	ENSP00000264313	Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro)	SLAIN motif-containing protein 2; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase	0.653
MPPED1	TBATA	ENSP00000388137	ENSP00000299290	Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro)	Protein TBATA; May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function	0.515
NUDCD2	PKIB	ENSP00000304854	ENSP00000480824	NudC domain-containing protein 2; May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone; NudC family	cAMP-dependent protein kinase inhibitor beta; Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains	0.457
PKIB	AKAP14	ENSP00000480824	ENSP00000360485	cAMP-dependent protein kinase inhibitor beta; Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains	A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins	0.608

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