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  • 11.0 [archived version]
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QDPR QDPR TYMS TYMS FLVCR2 FLVCR2 FOLR1 FOLR1 FPGS FPGS SLC46A1 SLC46A1 SLC19A1 SLC19A1 SLC11A2 SLC11A2 FOLR2 FOLR2 FLVCR1 FLVCR1 CYBRD1 CYBRD1
"SLC46A1" - Proton-coupled folate transporter in Homo sapiens
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Known Interactions
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experimentally determined
Predicted Interactions
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textmining
co-expression
protein homology
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SLC46A1Proton-coupled folate transporter; Has been shown to act both as an intestinal proton- coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme; Solute carriers (459 aa)    
Predicted Functional Partners:
SLC19A1
Folate transporter 1; Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H(+)-pump; Minor histocompatibility antigens (591 aa)
     
   
  0.794
FLVCR1
Feline leukemia virus subgroup C receptor-related protein 1; Isoform 1- Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythtopoiesis, a process in which heme synthesis intensifies. [...] (555 aa)
     
   
  0.772
QDPR
Dihydropteridine reductase; The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases; Short chain dehydrogenase/reductase superfamily (244 aa)
           
  0.760
FOLR1
Folate receptor alpha; Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation (257 aa)
           
  0.744
FLVCR2
Feline leukemia virus subgroup C receptor-related protein 2; Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism; Solute carriers (526 aa)
     
   
  0.720
SLC11A2
Natural resistance-associated macrophage protein 2; Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria; Belongs to the NRAMP family (590 aa)
           
  0.698
FOLR2
Folate receptor beta; Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (255 aa)
           
  0.684
CYBRD1
Cytochrome b reductase 1; Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells; Cytochrome b561 (286 aa)
           
  0.678
FPGS
Folylpolyglutamate synthase, mitochondrial; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates; Belongs to the folylpolyglutamate synthase family (587 aa)
           
  0.669
TYMS
Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway (313 aa)
           
  0.648
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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