node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABHD4 | HSD11B1L | ENSP00000414558 | ENSP00000480443 | Protein ABHD4; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethan [...] | Hydroxysteroid 11-beta-dehydrogenase 1-like protein; Short chain dehydrogenase/reductase superfamily; Belongs to the short-chain dehydrogenases/reductases (SDR) family | 0.421 |
ABHD4 | MFSD3 | ENSP00000414558 | ENSP00000301327 | Protein ABHD4; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethan [...] | Major facilitator superfamily domain containing 3 | 0.407 |
CCDC3 | HSD11B1L | ENSP00000368102 | ENSP00000480443 | Coiled-coil domain-containing protein 3; Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha- induced NF-kappaB activation in ECs. Positively regulates lipid accumulation in adipose cells (By similarity) | Hydroxysteroid 11-beta-dehydrogenase 1-like protein; Short chain dehydrogenase/reductase superfamily; Belongs to the short-chain dehydrogenases/reductases (SDR) family | 0.424 |
CCDC3 | MFSD3 | ENSP00000368102 | ENSP00000301327 | Coiled-coil domain-containing protein 3; Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha- induced NF-kappaB activation in ECs. Positively regulates lipid accumulation in adipose cells (By similarity) | Major facilitator superfamily domain containing 3 | 0.463 |
CCDC3 | ROGDI | ENSP00000368102 | ENSP00000322832 | Coiled-coil domain-containing protein 3; Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha- induced NF-kappaB activation in ECs. Positively regulates lipid accumulation in adipose cells (By similarity) | Protein rogdi homolog; May act as a positive regulator of cell proliferation; Belongs to the rogdi family | 0.423 |
DYSF | HSD11B1L | ENSP00000386881 | ENSP00000480443 | Dysferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity); Ferlin family | Hydroxysteroid 11-beta-dehydrogenase 1-like protein; Short chain dehydrogenase/reductase superfamily; Belongs to the short-chain dehydrogenases/reductases (SDR) family | 0.467 |
HSD11B1L | ABHD4 | ENSP00000480443 | ENSP00000414558 | Hydroxysteroid 11-beta-dehydrogenase 1-like protein; Short chain dehydrogenase/reductase superfamily; Belongs to the short-chain dehydrogenases/reductases (SDR) family | Protein ABHD4; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethan [...] | 0.421 |
HSD11B1L | CCDC3 | ENSP00000480443 | ENSP00000368102 | Hydroxysteroid 11-beta-dehydrogenase 1-like protein; Short chain dehydrogenase/reductase superfamily; Belongs to the short-chain dehydrogenases/reductases (SDR) family | Coiled-coil domain-containing protein 3; Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha- induced NF-kappaB activation in ECs. Positively regulates lipid accumulation in adipose cells (By similarity) | 0.424 |
HSD11B1L | DYSF | ENSP00000480443 | ENSP00000386881 | Hydroxysteroid 11-beta-dehydrogenase 1-like protein; Short chain dehydrogenase/reductase superfamily; Belongs to the short-chain dehydrogenases/reductases (SDR) family | Dysferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity); Ferlin family | 0.467 |
HSD11B1L | KLF13 | ENSP00000480443 | ENSP00000302456 | Hydroxysteroid 11-beta-dehydrogenase 1-like protein; Short chain dehydrogenase/reductase superfamily; Belongs to the short-chain dehydrogenases/reductases (SDR) family | Krueppel-like factor 13; Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells; Belongs to the Sp1 C2H2-type zinc-finger protein family | 0.439 |
HSD11B1L | LONP1 | ENSP00000480443 | ENSP00000353826 | Hydroxysteroid 11-beta-dehydrogenase 1-like protein; Short chain dehydrogenase/reductase superfamily; Belongs to the short-chain dehydrogenases/reductases (SDR) family | Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single- stranded, site-specific, and strand-specific manner. May regulate mi [...] | 0.559 |
HSD11B1L | MFSD3 | ENSP00000480443 | ENSP00000301327 | Hydroxysteroid 11-beta-dehydrogenase 1-like protein; Short chain dehydrogenase/reductase superfamily; Belongs to the short-chain dehydrogenases/reductases (SDR) family | Major facilitator superfamily domain containing 3 | 0.471 |
HSD11B1L | PPP2R1B | ENSP00000480443 | ENSP00000311344 | Hydroxysteroid 11-beta-dehydrogenase 1-like protein; Short chain dehydrogenase/reductase superfamily; Belongs to the short-chain dehydrogenases/reductases (SDR) family | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit; Armadillo-like helical domain containing | 0.500 |
HSD11B1L | PPP3R1 | ENSP00000480443 | ENSP00000234310 | Hydroxysteroid 11-beta-dehydrogenase 1-like protein; Short chain dehydrogenase/reductase superfamily; Belongs to the short-chain dehydrogenases/reductases (SDR) family | Calcineurin subunit B type 1; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity; EF-hand domain containing | 0.477 |
HSD11B1L | ROGDI | ENSP00000480443 | ENSP00000322832 | Hydroxysteroid 11-beta-dehydrogenase 1-like protein; Short chain dehydrogenase/reductase superfamily; Belongs to the short-chain dehydrogenases/reductases (SDR) family | Protein rogdi homolog; May act as a positive regulator of cell proliferation; Belongs to the rogdi family | 0.452 |
HSD11B1L | STEAP3 | ENSP00000480443 | ENSP00000376822 | Hydroxysteroid 11-beta-dehydrogenase 1-like protein; Short chain dehydrogenase/reductase superfamily; Belongs to the short-chain dehydrogenases/reductases (SDR) family | Metalloreductase STEAP3; Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP; STEAP family | 0.430 |
KLF13 | HSD11B1L | ENSP00000302456 | ENSP00000480443 | Krueppel-like factor 13; Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells; Belongs to the Sp1 C2H2-type zinc-finger protein family | Hydroxysteroid 11-beta-dehydrogenase 1-like protein; Short chain dehydrogenase/reductase superfamily; Belongs to the short-chain dehydrogenases/reductases (SDR) family | 0.439 |
LONP1 | HSD11B1L | ENSP00000353826 | ENSP00000480443 | Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single- stranded, site-specific, and strand-specific manner. May regulate mi [...] | Hydroxysteroid 11-beta-dehydrogenase 1-like protein; Short chain dehydrogenase/reductase superfamily; Belongs to the short-chain dehydrogenases/reductases (SDR) family | 0.559 |
MFSD3 | ABHD4 | ENSP00000301327 | ENSP00000414558 | Major facilitator superfamily domain containing 3 | Protein ABHD4; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethan [...] | 0.407 |
MFSD3 | CCDC3 | ENSP00000301327 | ENSP00000368102 | Major facilitator superfamily domain containing 3 | Coiled-coil domain-containing protein 3; Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha- induced NF-kappaB activation in ECs. Positively regulates lipid accumulation in adipose cells (By similarity) | 0.463 |