node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRA2 | ZFYVE16 | ENSP00000296785 | ENSP00000337159 | Ankyrin repeat family A protein 2; May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5. May also regulate LRP2/megalin (By similarity); Ankyrin repeat domain containing | Zinc finger FYVE domain-containing protein 16; May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes; Protein phosphatase 1 regulatory subunits | 0.530 |
ANKRA2 | ZNF761 | ENSP00000296785 | ENSP00000480218 | Ankyrin repeat family A protein 2; May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5. May also regulate LRP2/megalin (By similarity); Ankyrin repeat domain containing | Zinc finger protein 761; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.436 |
CARD8 | ZNF761 | ENSP00000375767 | ENSP00000480218 | Caspase recruitment domain-containing protein 8; Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases; Caspase recruitment domain containing | Zinc finger protein 761; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.476 |
CREG2 | RELL1 | ENSP00000315203 | ENSP00000398778 | Protein CREG2; Cellular repressor of E1A stimulated genes 2 | RELT-like protein 1; RELT family; Belongs to the RELT family | 0.422 |
CREG2 | SFXN3 | ENSP00000315203 | ENSP00000224807 | Protein CREG2; Cellular repressor of E1A stimulated genes 2 | Sideroflexin-3; Potential iron transporter; Sideroflexins | 0.444 |
CREG2 | SREK1IP1 | ENSP00000315203 | ENSP00000427401 | Protein CREG2; Cellular repressor of E1A stimulated genes 2 | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival | 0.447 |
CREG2 | ZNF761 | ENSP00000315203 | ENSP00000480218 | Protein CREG2; Cellular repressor of E1A stimulated genes 2 | Zinc finger protein 761; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.457 |
HTATIP2 | ZNF761 | ENSP00000392985 | ENSP00000480218 | Oxidoreductase HTATIP2; Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect; Short chain dehydrogenase/reductase superfamily | Zinc finger protein 761; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.446 |
IER5 | ZNF761 | ENSP00000356549 | ENSP00000480218 | Immediate early response gene 5 protein; Plays a role as a transcription factor. Mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1- dependent manner. Mediates negative transcriptional regulation of CDC25B expression. Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A. Involved in the regulation of cell proliferation and resistance to thermal stress. Involved in the cell cycle checkpoint and survival in response to ionizing radiation. Asso [...] | Zinc finger protein 761; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.416 |
RELL1 | CREG2 | ENSP00000398778 | ENSP00000315203 | RELT-like protein 1; RELT family; Belongs to the RELT family | Protein CREG2; Cellular repressor of E1A stimulated genes 2 | 0.422 |
RELL1 | SREK1IP1 | ENSP00000398778 | ENSP00000427401 | RELT-like protein 1; RELT family; Belongs to the RELT family | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival | 0.418 |
RELL1 | ZNF761 | ENSP00000398778 | ENSP00000480218 | RELT-like protein 1; RELT family; Belongs to the RELT family | Zinc finger protein 761; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.422 |
SFXN3 | CREG2 | ENSP00000224807 | ENSP00000315203 | Sideroflexin-3; Potential iron transporter; Sideroflexins | Protein CREG2; Cellular repressor of E1A stimulated genes 2 | 0.444 |
SFXN3 | SREK1IP1 | ENSP00000224807 | ENSP00000427401 | Sideroflexin-3; Potential iron transporter; Sideroflexins | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival | 0.426 |
SFXN3 | ZNF761 | ENSP00000224807 | ENSP00000480218 | Sideroflexin-3; Potential iron transporter; Sideroflexins | Zinc finger protein 761; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.440 |
SREK1IP1 | CREG2 | ENSP00000427401 | ENSP00000315203 | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival | Protein CREG2; Cellular repressor of E1A stimulated genes 2 | 0.447 |
SREK1IP1 | RELL1 | ENSP00000427401 | ENSP00000398778 | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival | RELT-like protein 1; RELT family; Belongs to the RELT family | 0.418 |
SREK1IP1 | SFXN3 | ENSP00000427401 | ENSP00000224807 | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival | Sideroflexin-3; Potential iron transporter; Sideroflexins | 0.426 |
SREK1IP1 | ZNF761 | ENSP00000427401 | ENSP00000480218 | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival | Zinc finger protein 761; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.447 |
TRIM28 | ZNF761 | ENSP00000253024 | ENSP00000480218 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 761; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.908 |