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STRINGSTRING
IER5 IER5 HTATIP2 HTATIP2 ZFYVE16 ZFYVE16 TRIM28 TRIM28 CARD8 CARD8 ZNF761 ZNF761 ANKRA2 ANKRA2 SFXN3 SFXN3 CREG2 CREG2 RELL1 RELL1 SREK1IP1 SREK1IP1
"ZNF761" - Zinc finger protein 761 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
ZNF761Zinc finger protein 761; May be involved in transcriptional regulation; Zinc fingers C2H2-type (746 aa)    
Predicted Functional Partners:
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
      
  0.908
CARD8
Caspase recruitment domain-containing protein 8; Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases; Caspase recruitment domain containing (537 aa)
        
 
  0.476
CREG2
Protein CREG2; Cellular repressor of E1A stimulated genes 2 (290 aa)
            
  0.457
SREK1IP1
Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival (155 aa)
            
  0.447
ZFYVE16
Zinc finger FYVE domain-containing protein 16; May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes; Protein phosphatase 1 regulatory subunits (1539 aa)
      
   
  0.446
HTATIP2
Oxidoreductase HTATIP2; Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect; Short chain dehydrogenase/reductase superfamily (276 aa)
            
  0.446
SFXN3
Sideroflexin-3; Potential iron transporter; Sideroflexins (325 aa)
            
  0.440
ANKRA2
Ankyrin repeat family A protein 2; May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5. May also regulate LRP2/megalin (By similarity); Ankyrin repeat domain containing (313 aa)
      
 
  0.436
RELL1
RELT-like protein 1; RELT family; Belongs to the RELT family (271 aa)
            
  0.422
IER5
Immediate early response gene 5 protein; Plays a role as a transcription factor. Mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1- dependent manner. Mediates negative transcriptional regulation of CDC25B expression. Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A. Involved in the regulation of cell proliferation and resistance to thermal stress. Involved in the cell cycle checkpoint and survival in response to ionizing radiation. Asso [...] (327 aa)
            
  0.416
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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