| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GPBP1L1 | MAST2 | ENSP00000347224 | ENSP00000354671 | Vasculin-like protein 1; Possible transcription factor | Microtubule-associated serine/threonine-protein kinase 2; Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity); PDZ domain containing | 0.438 |
| GPBP1L1 | TADA2A | ENSP00000347224 | ENSP00000481091 | Vasculin-like protein 1; Possible transcription factor | Transcriptional adapter 2-alpha; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 ’Lys-321’ acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in [...] | 0.520 |
| GPBP1L1 | ZNF700 | ENSP00000347224 | ENSP00000479449 | Vasculin-like protein 1; Possible transcription factor | Zinc finger protein 700; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.668 |
| MAST2 | GPBP1L1 | ENSP00000354671 | ENSP00000347224 | Microtubule-associated serine/threonine-protein kinase 2; Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity); PDZ domain containing | Vasculin-like protein 1; Possible transcription factor | 0.438 |
| MAST2 | ZNF700 | ENSP00000354671 | ENSP00000479449 | Microtubule-associated serine/threonine-protein kinase 2; Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity); PDZ domain containing | Zinc finger protein 700; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.409 |
| TADA2A | GPBP1L1 | ENSP00000481091 | ENSP00000347224 | Transcriptional adapter 2-alpha; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 ’Lys-321’ acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in [...] | Vasculin-like protein 1; Possible transcription factor | 0.520 |
| TADA2A | ZNF700 | ENSP00000481091 | ENSP00000479449 | Transcriptional adapter 2-alpha; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 ’Lys-321’ acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in [...] | Zinc finger protein 700; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.481 |
| TRIM28 | ZNF700 | ENSP00000253024 | ENSP00000479449 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 700; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.903 |
| ZNF321P | ZNF700 | ENSP00000375656 | ENSP00000479449 | Putative protein ZNF321; Zinc finger protein 321, pseudogene | Zinc finger protein 700; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.669 |
| ZNF638 | ZNF700 | ENSP00000386433 | ENSP00000479449 | Zinc finger protein 638; Early regulator of adipogenesis that works as a transcription cofactor of CEBPs, controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). Binds to cytidine clusters in double-stranded DNA. May also regulate alternative splicing of target genes during adipogenesis (By similarity); RNA binding motif containing | Zinc finger protein 700; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.442 |
| ZNF700 | GPBP1L1 | ENSP00000479449 | ENSP00000347224 | Zinc finger protein 700; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Vasculin-like protein 1; Possible transcription factor | 0.668 |
| ZNF700 | MAST2 | ENSP00000479449 | ENSP00000354671 | Zinc finger protein 700; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Microtubule-associated serine/threonine-protein kinase 2; Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity); PDZ domain containing | 0.409 |
| ZNF700 | TADA2A | ENSP00000479449 | ENSP00000481091 | Zinc finger protein 700; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Transcriptional adapter 2-alpha; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 ’Lys-321’ acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in [...] | 0.481 |
| ZNF700 | TRIM28 | ENSP00000479449 | ENSP00000253024 | Zinc finger protein 700; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.903 |
| ZNF700 | ZNF321P | ENSP00000479449 | ENSP00000375656 | Zinc finger protein 700; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Putative protein ZNF321; Zinc finger protein 321, pseudogene | 0.669 |
| ZNF700 | ZNF638 | ENSP00000479449 | ENSP00000386433 | Zinc finger protein 700; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Zinc finger protein 638; Early regulator of adipogenesis that works as a transcription cofactor of CEBPs, controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). Binds to cytidine clusters in double-stranded DNA. May also regulate alternative splicing of target genes during adipogenesis (By similarity); RNA binding motif containing | 0.442 |
