LENG9 protein (human) - STRING database

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LENG9

Leukocyte receptor cluster member 9 (478 aa)

Predicted Functional Partners:

FAM45A

0.715

ZC3HAV1L

0.544

ZC3H15

0.530

MTRNR2L6

0.529

NOLC1

0.504

RAB31

0.491

EIF4EBP2

0.485

RBM26

0.478

ZC3H7A

0.476

ZC3H12B

0.476

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIF4EBP2	LENG9	ENSP00000362314	ENSP00000479355	Eukaryotic translation initiation factor 4E-binding protein 2; Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (By similarity). Regulates EIF4E activity by preventing its assembly into the eIF4F complex- hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. EIF4EBP2 is enriched in brain and acts as a regulator of s [...]	Leukocyte receptor cluster member 9	0.485
FAM45A	LENG9	ENSP00000354688	ENSP00000479355	Protein FAM45A; Family with sequence similarity 45 member A	Leukocyte receptor cluster member 9	0.715
FAM45A	NOLC1	ENSP00000354688	ENSP00000385410	Protein FAM45A; Family with sequence similarity 45 member A	Nucleolar and coiled-body phosphoprotein 1; Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification- following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification. Involved in nucleologenesis, possibly [...]	0.514
FAM45A	RAB31	ENSP00000354688	ENSP00000461945	Protein FAM45A; Family with sequence similarity 45 member A	Ras-related protein Rab-31; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Pl [...]	0.577
LENG9	EIF4EBP2	ENSP00000479355	ENSP00000362314	Leukocyte receptor cluster member 9	Eukaryotic translation initiation factor 4E-binding protein 2; Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (By similarity). Regulates EIF4E activity by preventing its assembly into the eIF4F complex- hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. EIF4EBP2 is enriched in brain and acts as a regulator of s [...]	0.485
LENG9	FAM45A	ENSP00000479355	ENSP00000354688	Leukocyte receptor cluster member 9	Protein FAM45A; Family with sequence similarity 45 member A	0.715
LENG9	MTRNR2L6	ENSP00000479355	ENSP00000473686	Leukocyte receptor cluster member 9	Humanin-like 6; Plays a role as a neuroprotective and antiapoptotic factor; Belongs to the humanin family	0.529
LENG9	NOLC1	ENSP00000479355	ENSP00000385410	Leukocyte receptor cluster member 9	Nucleolar and coiled-body phosphoprotein 1; Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification- following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification. Involved in nucleologenesis, possibly [...]	0.504
LENG9	RAB31	ENSP00000479355	ENSP00000461945	Leukocyte receptor cluster member 9	Ras-related protein Rab-31; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Pl [...]	0.491
LENG9	RBM26	ENSP00000479355	ENSP00000483408	Leukocyte receptor cluster member 9	RNA-binding protein 26; Protein phosphatase 1 regulatory subunits	0.478
LENG9	ZC3H12B	ENSP00000479355	ENSP00000340839	Leukocyte receptor cluster member 9	Probable ribonuclease ZC3H12B; May function as RNase and regulate the levels of target RNA species; Zinc fingers CCCH-type	0.476
LENG9	ZC3H15	ENSP00000479355	ENSP00000338788	Leukocyte receptor cluster member 9	Zinc finger CCCH domain-containing protein 15; Protects DRG1 from proteolytic degradation; Zinc fingers CCCH-type	0.530
LENG9	ZC3H7A	ENSP00000479355	ENSP00000379773	Leukocyte receptor cluster member 9	Zinc finger CCCH domain-containing protein 7A; May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3’-ATA(A/T)-5’ motif in the apical loop; Tetratricopeptide repeat domain containing	0.476
LENG9	ZC3HAV1L	ENSP00000479355	ENSP00000275766	Leukocyte receptor cluster member 9	Zinc finger CCCH-type containing, antiviral 1 like	0.544
MTRNR2L6	LENG9	ENSP00000473686	ENSP00000479355	Humanin-like 6; Plays a role as a neuroprotective and antiapoptotic factor; Belongs to the humanin family	Leukocyte receptor cluster member 9	0.529
NOLC1	FAM45A	ENSP00000385410	ENSP00000354688	Nucleolar and coiled-body phosphoprotein 1; Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification- following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification. Involved in nucleologenesis, possibly [...]	Protein FAM45A; Family with sequence similarity 45 member A	0.514
NOLC1	LENG9	ENSP00000385410	ENSP00000479355	Nucleolar and coiled-body phosphoprotein 1; Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification- following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification. Involved in nucleologenesis, possibly [...]	Leukocyte receptor cluster member 9	0.504
RAB31	FAM45A	ENSP00000461945	ENSP00000354688	Ras-related protein Rab-31; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Pl [...]	Protein FAM45A; Family with sequence similarity 45 member A	0.577
RAB31	LENG9	ENSP00000461945	ENSP00000479355	Ras-related protein Rab-31; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Pl [...]	Leukocyte receptor cluster member 9	0.491
RBM26	LENG9	ENSP00000483408	ENSP00000479355	RNA-binding protein 26; Protein phosphatase 1 regulatory subunits	Leukocyte receptor cluster member 9	0.478

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