node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GABBR1 | JAKMIP2 | ENSP00000366233 | ENSP00000479248 | Gamma-aminobutyric acid type B receptor subunit 1; Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-depend [...] | Janus kinase and microtubule interacting protein 2; Belongs to the JAKMIP family | 0.655 |
GRXCR2 | JAKMIP2 | ENSP00000367214 | ENSP00000479248 | Glutaredoxin domain-containing cysteine-rich protein 2; Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection; Deafness associated genes | Janus kinase and microtubule interacting protein 2; Belongs to the JAKMIP family | 0.517 |
GRXCR2 | STK32A | ENSP00000367214 | ENSP00000381535 | Glutaredoxin domain-containing cysteine-rich protein 2; Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection; Deafness associated genes | Serine/threonine kinase 32A | 0.485 |
GRXCR2 | YIPF5 | ENSP00000367214 | ENSP00000274496 | Glutaredoxin domain-containing cysteine-rich protein 2; Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection; Deafness associated genes | Protein YIPF5; Plays a role in transport between endoplasmic reticulum and Golgi; Yip1 domain containing | 0.761 |
IFNLR1 | IL4I1 | ENSP00000327824 | ENSP00000472474 | Interferon lambda receptor 1; The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, [...] | L-amino-acid oxidase; Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity); Belongs to the flavin monoamine oxidase family. FIG1 subfamily | 0.466 |
IFNLR1 | JAKMIP2 | ENSP00000327824 | ENSP00000479248 | Interferon lambda receptor 1; The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, [...] | Janus kinase and microtubule interacting protein 2; Belongs to the JAKMIP family | 0.517 |
IL4I1 | IFNLR1 | ENSP00000472474 | ENSP00000327824 | L-amino-acid oxidase; Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity); Belongs to the flavin monoamine oxidase family. FIG1 subfamily | Interferon lambda receptor 1; The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, [...] | 0.466 |
IL4I1 | JAKMIP2 | ENSP00000472474 | ENSP00000479248 | L-amino-acid oxidase; Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity); Belongs to the flavin monoamine oxidase family. FIG1 subfamily | Janus kinase and microtubule interacting protein 2; Belongs to the JAKMIP family | 0.588 |
JAKMIP2 | GABBR1 | ENSP00000479248 | ENSP00000366233 | Janus kinase and microtubule interacting protein 2; Belongs to the JAKMIP family | Gamma-aminobutyric acid type B receptor subunit 1; Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-depend [...] | 0.655 |
JAKMIP2 | GRXCR2 | ENSP00000479248 | ENSP00000367214 | Janus kinase and microtubule interacting protein 2; Belongs to the JAKMIP family | Glutaredoxin domain-containing cysteine-rich protein 2; Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection; Deafness associated genes | 0.517 |
JAKMIP2 | IFNLR1 | ENSP00000479248 | ENSP00000327824 | Janus kinase and microtubule interacting protein 2; Belongs to the JAKMIP family | Interferon lambda receptor 1; The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, [...] | 0.517 |
JAKMIP2 | IL4I1 | ENSP00000479248 | ENSP00000472474 | Janus kinase and microtubule interacting protein 2; Belongs to the JAKMIP family | L-amino-acid oxidase; Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity); Belongs to the flavin monoamine oxidase family. FIG1 subfamily | 0.588 |
JAKMIP2 | SRRM4 | ENSP00000479248 | ENSP00000267260 | Janus kinase and microtubule interacting protein 2; Belongs to the JAKMIP family | Serine/arginine repetitive matrix protein 4; Splicing factor specifically required for neural cell differentiation. Acts in conjuction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural- specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural- specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts (By similarity) | 0.549 |
JAKMIP2 | STK32A | ENSP00000479248 | ENSP00000381535 | Janus kinase and microtubule interacting protein 2; Belongs to the JAKMIP family | Serine/threonine kinase 32A | 0.787 |
JAKMIP2 | THSD7A | ENSP00000479248 | ENSP00000406482 | Janus kinase and microtubule interacting protein 2; Belongs to the JAKMIP family | Thrombospondin type-1 domain-containing protein 7A; The soluble form promotes endothelial cell migration and filopodia formationduring angiogenesis via a FAK-dependent mechanism | 0.529 |
JAKMIP2 | TMEM177 | ENSP00000479248 | ENSP00000402661 | Janus kinase and microtubule interacting protein 2; Belongs to the JAKMIP family | Transmembrane protein 177 | 0.519 |
JAKMIP2 | VAT1L | ENSP00000479248 | ENSP00000303129 | Janus kinase and microtubule interacting protein 2; Belongs to the JAKMIP family | Synaptic vesicle membrane protein VAT-1 homolog-like; Vesicle amine transport 1 like; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily | 0.582 |
JAKMIP2 | YIPF5 | ENSP00000479248 | ENSP00000274496 | Janus kinase and microtubule interacting protein 2; Belongs to the JAKMIP family | Protein YIPF5; Plays a role in transport between endoplasmic reticulum and Golgi; Yip1 domain containing | 0.517 |
SRRM4 | JAKMIP2 | ENSP00000267260 | ENSP00000479248 | Serine/arginine repetitive matrix protein 4; Splicing factor specifically required for neural cell differentiation. Acts in conjuction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural- specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural- specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts (By similarity) | Janus kinase and microtubule interacting protein 2; Belongs to the JAKMIP family | 0.549 |
SRRM4 | THSD7A | ENSP00000267260 | ENSP00000406482 | Serine/arginine repetitive matrix protein 4; Splicing factor specifically required for neural cell differentiation. Acts in conjuction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural- specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural- specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts (By similarity) | Thrombospondin type-1 domain-containing protein 7A; The soluble form promotes endothelial cell migration and filopodia formationduring angiogenesis via a FAK-dependent mechanism | 0.404 |