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  • 11.0 [archived version]
STRINGSTRING
VGLL1 VGLL1 TBR1 TBR1 PTCHD3 PTCHD3 GPR85 GPR85 SNX33 SNX33 NFE2L2 NFE2L2 ENC1 ENC1 NUDCD3 NUDCD3 CUL3 CUL3 KLHL25 KLHL25 HEXB HEXB
"ENC1" - Ectoderm-neural cortex protein 1 in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ENC1Ectoderm-neural cortex protein 1; Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin- mediated proteasomal degradation mechanism; BTB domain containing (589 aa)    
Predicted Functional Partners:
VGLL1
Transcription cofactor vestigial-like protein 1; May act as a specific coactivator for the mammalian TEFs; Belongs to the vestigial family (258 aa)
           
  0.920
KLHL25
Kelch-like protein 25; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1)- ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E; BTB domain con [...] (589 aa)
       
 
0.855
HEXB
Beta-hexosaminidase subunit beta; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues; Belongs to the glycosyl hydrolase 20 family (556 aa)
     
   
  0.807
SNX33
Sorting nexin-33; Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macr [...] (574 aa)
           
  0.799
CUL3
Cullin-3; Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cu [...] (768 aa)
     
 
  0.753
GPR85
Probable G-protein coupled receptor 85; Orphan receptor; Belongs to the G-protein coupled receptor 1 family (370 aa)
           
  0.740
NFE2L2
Nuclear factor erythroid 2-related factor 2; Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region; Basic leucine zipper proteins (605 aa)
       
 
  0.717
PTCHD3
Patched domain-containing protein 3; May play a role in sperm development or sperm function (767 aa)
     
   
  0.716
TBR1
T-box brain protein 1; Probable transcriptional regulator involved in developmental processes. Required for normal brain development; T-boxes (682 aa)
           
  0.715
NUDCD3
NudC domain containing 3 (361 aa)
     
      0.694
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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