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  • 11.0 [archived version]
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CNPY4 CNPY4 FASTKD5 FASTKD5 ETFDH ETFDH TYSND1 TYSND1 AIFM2 AIFM2 SUOX SUOX CYCS CYCS GSR GSR TP53 TP53 GADD45GIP1 GADD45GIP1 ENDOG ENDOG
"AIFM2" - Apoptosis-inducing factor 2 in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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AIFM2Apoptosis-inducing factor 2; Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest; Belongs to the FAD-dependent oxidoreductase family (373 aa)    
Predicted Functional Partners:
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in [...] (393 aa)
       
  0.931
GADD45GIP1
Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis (222 aa)
           
  0.800
TYSND1
Peroxisomal leader peptide-processing protease; Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta- oxidation of fatty acids (566 aa)
 
 
   
  0.627
SUOX
Sulfite oxidase, mitochondrial; Sulfite oxidase (545 aa)
         
  0.572
GSR
Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol (522 aa)
   
   
  0.564
ETFDH
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial; Accepts electrons from ETF and reduces ubiquinone; Belongs to the ETF-QO/FixC family (617 aa)
   
 
  0.553
FASTKD5
FAST kinase domain-containing protein 5, mitochondrial; Plays an important role in the processing of non- canonical mitochondrial mRNA precursors; FASTK mitochondrial RNA binding family (764 aa)
           
  0.552
CYCS
Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (105 aa)
     
   
  0.551
ENDOG
Endonuclease G, mitochondrial; Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity); Belongs to the DNA/RNA non-specific endonuclease family (297 aa)
     
 
  0.544
CNPY4
Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4 (248 aa)
       
      0.533
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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