| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGFG1 | ENSG00000274611 | ENSP00000387282 | ENSP00000478683 | Arf-GAP domain and FG repeat-containing protein 1; Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element- containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication; ArfGAPs | TBC1 domain family, member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 | 0.554 |
| AGFG1 | RAB5A | ENSP00000387282 | ENSP00000273047 | Arf-GAP domain and FG repeat-containing protein 1; Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element- containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication; ArfGAPs | Ras-related protein Rab-5A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6I [...] | 0.970 |
| ENSG00000274611 | AGFG1 | ENSP00000478683 | ENSP00000387282 | TBC1 domain family, member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 | Arf-GAP domain and FG repeat-containing protein 1; Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element- containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication; ArfGAPs | 0.554 |
| ENSG00000274611 | FBXW8 | ENSP00000478683 | ENSP00000310686 | TBC1 domain family, member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 | F-box/WD repeat-containing protein 8; Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner- the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 ki [...] | 0.678 |
| ENSG00000274611 | IRS1 | ENSP00000478683 | ENSP00000304895 | TBC1 domain family, member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 | Insulin receptor substrate 1; May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity) | 0.528 |
| ENSG00000274611 | NBPF26 | ENSP00000478683 | ENSP00000479693 | TBC1 domain family, member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 | Neuroblastoma breakpoint family member 14; NBPF member 14 | 0.489 |
| ENSG00000274611 | NPIPA1 | ENSP00000478683 | ENSP00000331843 | TBC1 domain family, member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 | Nuclear pore complex interacting protein family member A1 | 0.489 |
| ENSG00000274611 | PRR20A | ENSP00000478683 | ENSP00000367164 | TBC1 domain family, member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 | Proline rich 20A | 0.556 |
| ENSG00000274611 | RAB5A | ENSP00000478683 | ENSP00000273047 | TBC1 domain family, member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 | Ras-related protein Rab-5A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6I [...] | 0.698 |
| ENSG00000274611 | TBC1D30 | ENSP00000478683 | ENSP00000440207 | TBC1 domain family, member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 | TBC1 domain family member 30; GTPase-activating protein (GAP) with broad specificity. Acts as a GAP for RAB3A. Also exhibits significant GAP activity toward RAB22A, RAB27A, and RAB35 in vitro | 0.480 |
| ENSG00000274611 | TRNP1 | ENSP00000478683 | ENSP00000429216 | TBC1 domain family, member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 | TMF-regulated nuclear protein 1; DNA-binding factor that regulates the expression of a subset of genes and plays a key role in tangential, radial, and lateral expansion of the brain neocortex. Regulates neural stem cells proliferation and the production of intermediate neural progenitors and basal radial glial cells affecting the process of cerebral cortex gyrification. May control the proliferation rate of cells by regulating their progression through key cell-cycle transition points (By similarity) | 0.557 |
| ENSG00000274611 | USP32 | ENSP00000478683 | ENSP00000300896 | TBC1 domain family, member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 | Ubiquitin specific peptidase 32; Belongs to the peptidase C19 family | 0.912 |
| FBXW8 | ENSG00000274611 | ENSP00000310686 | ENSP00000478683 | F-box/WD repeat-containing protein 8; Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner- the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 ki [...] | TBC1 domain family, member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 | 0.678 |
| FBXW8 | IRS1 | ENSP00000310686 | ENSP00000304895 | F-box/WD repeat-containing protein 8; Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner- the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 ki [...] | Insulin receptor substrate 1; May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity) | 0.687 |
| IRS1 | ENSG00000274611 | ENSP00000304895 | ENSP00000478683 | Insulin receptor substrate 1; May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity) | TBC1 domain family, member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 | 0.528 |
| IRS1 | FBXW8 | ENSP00000304895 | ENSP00000310686 | Insulin receptor substrate 1; May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity) | F-box/WD repeat-containing protein 8; Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner- the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 ki [...] | 0.687 |
| NBPF26 | ENSG00000274611 | ENSP00000479693 | ENSP00000478683 | Neuroblastoma breakpoint family member 14; NBPF member 14 | TBC1 domain family, member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 | 0.489 |
| NBPF26 | PRR20A | ENSP00000479693 | ENSP00000367164 | Neuroblastoma breakpoint family member 14; NBPF member 14 | Proline rich 20A | 0.440 |
| NPIPA1 | ENSG00000274611 | ENSP00000331843 | ENSP00000478683 | Nuclear pore complex interacting protein family member A1 | TBC1 domain family, member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 | 0.489 |
| PRR20A | ENSG00000274611 | ENSP00000367164 | ENSP00000478683 | Proline rich 20A | TBC1 domain family, member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 | 0.556 |
