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  • 11.0 [archived version]
STRINGSTRING
SRPK3 SRPK3 PICK1 PICK1 SGSM1 SGSM1 C8orf44 C8orf44 ICA1L ICA1L CYP20A1 CYP20A1 OPA3 OPA3 GK5 GK5 JAKMIP3 JAKMIP3 PRR11 PRR11 OR2L13 OR2L13
"ICA1L" - Islet cell autoantigen 1-like protein in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
ICA1LIslet cell autoantigen 1-like protein; Classical BAR domain containing (482 aa)    
Predicted Functional Partners:
PICK1
PRKCA-binding protein; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive w [...] (415 aa)
      
 
  0.812
C8orf44
Putative uncharacterized protein C8orf44; Chromosome 8 open reading frame 44 (159 aa)
            
  0.765
CYP20A1
Cytochrome P450 family 20 subfamily A member 1 (462 aa)
        
 
  0.763
GK5
Glycerol kinase 5 (529 aa)
            
  0.734
OPA3
Optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia); OPA3, outer mitochondrial membrane lipid metabolism regulator (180 aa)
            
  0.730
SRPK3
SRSF protein kinase 3; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development (By similarity) (567 aa)
            
  0.692
PRR11
Proline-rich protein 11; Plays a critical role in cell cycle progression (360 aa)
            
  0.683
JAKMIP3
Janus kinase and microtubule interacting protein 3 (844 aa)
      
   
  0.611
OR2L13
Olfactory receptor 2L13; Odorant receptor; Olfactory receptors, family 2 (312 aa)
            
  0.602
SGSM1
Small G protein signaling modulator 1; Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. Promotes GTP hydrolysis by RAB34 and RAB36. Probably functions as GTPase effector with RAB9A and RAB9B; does not stimulate GTP hydrolysis with RAB9A and RAB9B; Belongs to the RUTBC family (1148 aa)
      
 
  0.583
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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