node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALDH18A1 | CCNI2 | ENSP00000360268 | ENSP00000478257 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine | Cyclin-I2; Cyclin I family member 2; Cyclins | 0.731 |
ALDH18A1 | CDC6 | ENSP00000360268 | ENSP00000209728 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | 0.446 |
ALDH18A1 | CKS2 | ENSP00000360268 | ENSP00000364976 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine | Cyclin-dependent kinases regulatory subunit 2; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function | 0.814 |
ALDH18A1 | ORC1 | ENSP00000360268 | ENSP00000360623 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication; Belongs to the ORC1 family | 0.424 |
CCNI2 | ALDH18A1 | ENSP00000478257 | ENSP00000360268 | Cyclin-I2; Cyclin I family member 2; Cyclins | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine | 0.731 |
CCNI2 | CDC6 | ENSP00000478257 | ENSP00000209728 | Cyclin-I2; Cyclin I family member 2; Cyclins | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | 0.555 |
CCNI2 | CDK1 | ENSP00000478257 | ENSP00000378699 | Cyclin-I2; Cyclin I family member 2; Cyclins | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl- xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, [...] | 0.512 |
CCNI2 | CDK16 | ENSP00000478257 | ENSP00000276052 | Cyclin-I2; Cyclin I family member 2; Cyclins | Cyclin-dependent kinase 16; Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at ’Ser- 336’ (in vitro); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily | 0.626 |
CCNI2 | CDK18 | ENSP00000478257 | ENSP00000423665 | Cyclin-I2; Cyclin I family member 2; Cyclins | Cyclin-dependent kinase 18; May play a role in signal transduction cascades in terminally differentiated cells; Cyclin dependent kinases | 0.731 |
CCNI2 | CDK3 | ENSP00000478257 | ENSP00000410561 | Cyclin-I2; Cyclin I family member 2; Cyclins | Cyclin-dependent kinase 3; Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0- G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1 [...] | 0.610 |
CCNI2 | CKS2 | ENSP00000478257 | ENSP00000364976 | Cyclin-I2; Cyclin I family member 2; Cyclins | Cyclin-dependent kinases regulatory subunit 2; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function | 0.497 |
CCNI2 | ENSG00000272772 | ENSP00000478257 | ENSP00000430774 | Cyclin-I2; Cyclin I family member 2; Cyclins | Uncharacterized protein; Belongs to the SKP1 family | 0.673 |
CCNI2 | ORC1 | ENSP00000478257 | ENSP00000360623 | Cyclin-I2; Cyclin I family member 2; Cyclins | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication; Belongs to the ORC1 family | 0.503 |
CCNI2 | TEN1-CDK3 | ENSP00000478257 | ENSP00000400088 | Cyclin-I2; Cyclin I family member 2; Cyclins | TEN1-CDK3 readthrough (NMD candidate); Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0- G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E [...] | 0.610 |
CDC6 | ALDH18A1 | ENSP00000209728 | ENSP00000360268 | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine | 0.446 |
CDC6 | CCNI2 | ENSP00000209728 | ENSP00000478257 | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | Cyclin-I2; Cyclin I family member 2; Cyclins | 0.555 |
CDC6 | CDK1 | ENSP00000209728 | ENSP00000378699 | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl- xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, [...] | 0.992 |
CDC6 | CDK16 | ENSP00000209728 | ENSP00000276052 | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | Cyclin-dependent kinase 16; Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at ’Ser- 336’ (in vitro); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily | 0.720 |
CDC6 | CDK18 | ENSP00000209728 | ENSP00000423665 | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | Cyclin-dependent kinase 18; May play a role in signal transduction cascades in terminally differentiated cells; Cyclin dependent kinases | 0.725 |
CDC6 | CDK3 | ENSP00000209728 | ENSP00000410561 | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | Cyclin-dependent kinase 3; Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0- G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1 [...] | 0.848 |