| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DFNB59 | GJB2 | ENSP00000386647 | ENSP00000372295 | Pejvakin; Essential in the activity of auditory pathway neurons | Gap junction beta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Deafness associated genes | 0.671 |
| DFNB59 | MYO15A | ENSP00000386647 | ENSP00000205890 | Pejvakin; Essential in the activity of auditory pathway neurons | Unconventional myosin-XV; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles (By similarity); Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | 0.669 |
| DFNB59 | OTOA | ENSP00000386647 | ENSP00000373610 | Pejvakin; Essential in the activity of auditory pathway neurons | Otoancorin; May act as an adhesion molecule; Belongs to the stereocilin family | 0.678 |
| DFNB59 | OTOF | ENSP00000386647 | ENSP00000272371 | Pejvakin; Essential in the activity of auditory pathway neurons | Otoferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes (By similarity); Deafness associated genes | 0.791 |
| DFNB59 | SLC26A4 | ENSP00000386647 | ENSP00000265715 | Pejvakin; Essential in the activity of auditory pathway neurons | Pendrin; Sodium-independent transporter of chloride and iodide; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family | 0.675 |
| DFNB59 | STRC | ENSP00000386647 | ENSP00000401513 | Pejvakin; Essential in the activity of auditory pathway neurons | Stereocilin; Essential to the formation of horizontal top connectors between outer hair cell stereocilia; Belongs to the stereocilin family | 0.557 |
| DFNB59 | TMC1 | ENSP00000386647 | ENSP00000297784 | Pejvakin; Essential in the activity of auditory pathway neurons | Transmembrane channel-like protein 1; Probable ion channel required for the normal function of cochlear hair cells; Belongs to the TMC family | 0.739 |
| DFNB59 | TMPRSS4 | ENSP00000386647 | ENSP00000477949 | Pejvakin; Essential in the activity of auditory pathway neurons | Transmembrane protease serine 4; Probable protease. Seems to be capable of activating ENaC (By similarity); Scavenger receptor cysteine rich domain containing | 0.642 |
| FURIN | TMPRSS2 | ENSP00000483552 | ENSP00000381588 | Furin; Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif; Proprotein convertase subtilisin/kexin family | Transmembrane protease serine 2; Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus- cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which ac [...] | 0.531 |
| FURIN | TMPRSS4 | ENSP00000483552 | ENSP00000477949 | Furin; Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif; Proprotein convertase subtilisin/kexin family | Transmembrane protease serine 4; Probable protease. Seems to be capable of activating ENaC (By similarity); Scavenger receptor cysteine rich domain containing | 0.663 |
| GJB2 | DFNB59 | ENSP00000372295 | ENSP00000386647 | Gap junction beta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Deafness associated genes | Pejvakin; Essential in the activity of auditory pathway neurons | 0.671 |
| GJB2 | MYO15A | ENSP00000372295 | ENSP00000205890 | Gap junction beta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Deafness associated genes | Unconventional myosin-XV; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles (By similarity); Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | 0.738 |
| GJB2 | OTOA | ENSP00000372295 | ENSP00000373610 | Gap junction beta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Deafness associated genes | Otoancorin; May act as an adhesion molecule; Belongs to the stereocilin family | 0.603 |
| GJB2 | OTOF | ENSP00000372295 | ENSP00000272371 | Gap junction beta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Deafness associated genes | Otoferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes (By similarity); Deafness associated genes | 0.739 |
| GJB2 | SLC26A4 | ENSP00000372295 | ENSP00000265715 | Gap junction beta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Deafness associated genes | Pendrin; Sodium-independent transporter of chloride and iodide; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family | 0.899 |
| GJB2 | STRC | ENSP00000372295 | ENSP00000401513 | Gap junction beta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Deafness associated genes | Stereocilin; Essential to the formation of horizontal top connectors between outer hair cell stereocilia; Belongs to the stereocilin family | 0.676 |
| GJB2 | TMC1 | ENSP00000372295 | ENSP00000297784 | Gap junction beta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Deafness associated genes | Transmembrane channel-like protein 1; Probable ion channel required for the normal function of cochlear hair cells; Belongs to the TMC family | 0.741 |
| GJB2 | TMPRSS4 | ENSP00000372295 | ENSP00000477949 | Gap junction beta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Deafness associated genes | Transmembrane protease serine 4; Probable protease. Seems to be capable of activating ENaC (By similarity); Scavenger receptor cysteine rich domain containing | 0.641 |
| MYO15A | DFNB59 | ENSP00000205890 | ENSP00000386647 | Unconventional myosin-XV; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles (By similarity); Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | Pejvakin; Essential in the activity of auditory pathway neurons | 0.669 |
| MYO15A | GJB2 | ENSP00000205890 | ENSP00000372295 | Unconventional myosin-XV; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles (By similarity); Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | Gap junction beta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Deafness associated genes | 0.738 |
