TPT1 protein (human) - STRING database

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TPT1

Translationally-controlled tumor protein; Involved in calcium binding and microtubule stabilization (197 aa)

Predicted Functional Partners:

BCL2L1

0.989

PLK1

0.982

RPS25

0.981

RPL27

0.980

RPS3A

0.973

EEF1B2

0.973

STEAP3

0.974

RPL30

0.971

RPS12

0.969

RPL9

0.968

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2L1	PLK1	ENSP00000302564	ENSP00000300093	Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis; Belongs to the Bcl-2 family	Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CC [...]	0.611
BCL2L1	TPT1	ENSP00000302564	ENSP00000477781	Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis; Belongs to the Bcl-2 family	Translationally-controlled tumor protein; Involved in calcium binding and microtubule stabilization	0.989
EEF1B2	RPL27	ENSP00000376056	ENSP00000464813	Elongation factor 1-beta; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP	60S ribosomal protein L27; Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs	0.986
EEF1B2	RPL30	ENSP00000376056	ENSP00000428085	Elongation factor 1-beta; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP	Ribosomal protein L30; Belongs to the eukaryotic ribosomal protein eL30 family	0.968
EEF1B2	RPL9	ENSP00000376056	ENSP00000400467	Elongation factor 1-beta; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP	L ribosomal proteins	0.987
EEF1B2	RPS12	ENSP00000376056	ENSP00000230050	Elongation factor 1-beta; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP	Ribosomal protein S12	0.940
EEF1B2	RPS25	ENSP00000376056	ENSP00000435096	Elongation factor 1-beta; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP	Ribosomal protein S25	0.932
EEF1B2	RPS3A	ENSP00000376056	ENSP00000346050	Elongation factor 1-beta; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP	40S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3; Belongs to the eukaryotic ribosomal protein eS1 family	0.964
EEF1B2	TPT1	ENSP00000376056	ENSP00000477781	Elongation factor 1-beta; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP	Translationally-controlled tumor protein; Involved in calcium binding and microtubule stabilization	0.973
PLK1	BCL2L1	ENSP00000300093	ENSP00000302564	Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CC [...]	Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis; Belongs to the Bcl-2 family	0.611
PLK1	TPT1	ENSP00000300093	ENSP00000477781	Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CC [...]	Translationally-controlled tumor protein; Involved in calcium binding and microtubule stabilization	0.982
RPL27	EEF1B2	ENSP00000464813	ENSP00000376056	60S ribosomal protein L27; Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs	Elongation factor 1-beta; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP	0.986
RPL27	RPL30	ENSP00000464813	ENSP00000428085	60S ribosomal protein L27; Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs	Ribosomal protein L30; Belongs to the eukaryotic ribosomal protein eL30 family	0.999
RPL27	RPL9	ENSP00000464813	ENSP00000400467	60S ribosomal protein L27; Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs	L ribosomal proteins	0.999
RPL27	RPS12	ENSP00000464813	ENSP00000230050	60S ribosomal protein L27; Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs	Ribosomal protein S12	0.999
RPL27	RPS25	ENSP00000464813	ENSP00000435096	60S ribosomal protein L27; Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs	Ribosomal protein S25	0.999
RPL27	RPS3A	ENSP00000464813	ENSP00000346050	60S ribosomal protein L27; Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs	40S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3; Belongs to the eukaryotic ribosomal protein eS1 family	0.999
RPL27	TPT1	ENSP00000464813	ENSP00000477781	60S ribosomal protein L27; Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs	Translationally-controlled tumor protein; Involved in calcium binding and microtubule stabilization	0.980
RPL30	EEF1B2	ENSP00000428085	ENSP00000376056	Ribosomal protein L30; Belongs to the eukaryotic ribosomal protein eL30 family	Elongation factor 1-beta; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP	0.968
RPL30	RPL27	ENSP00000428085	ENSP00000464813	Ribosomal protein L30; Belongs to the eukaryotic ribosomal protein eL30 family	60S ribosomal protein L27; Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs	0.999

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