node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AQP10 | AQP11 | ENSP00000318355 | ENSP00000318770 | Aquaporin-10; Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol; Belongs to the MIP/aquaporin (TC 1.A.8) family | Aquaporin-11; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes | 0.826 |
AQP10 | AQP12A | ENSP00000318355 | ENSP00000405899 | Aquaporin-10; Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol; Belongs to the MIP/aquaporin (TC 1.A.8) family | Aquaporin-12A; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes; Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily | 0.886 |
AQP10 | AQP6 | ENSP00000318355 | ENSP00000477688 | Aquaporin-10; Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol; Belongs to the MIP/aquaporin (TC 1.A.8) family | Aquaporin-6; Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism; Aquaporins | 0.906 |
AQP11 | AQP10 | ENSP00000318770 | ENSP00000318355 | Aquaporin-11; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes | Aquaporin-10; Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol; Belongs to the MIP/aquaporin (TC 1.A.8) family | 0.826 |
AQP11 | AQP6 | ENSP00000318770 | ENSP00000477688 | Aquaporin-11; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes | Aquaporin-6; Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism; Aquaporins | 0.844 |
AQP12A | AQP10 | ENSP00000405899 | ENSP00000318355 | Aquaporin-12A; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes; Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily | Aquaporin-10; Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol; Belongs to the MIP/aquaporin (TC 1.A.8) family | 0.886 |
AQP12A | AQP6 | ENSP00000405899 | ENSP00000477688 | Aquaporin-12A; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes; Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily | Aquaporin-6; Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism; Aquaporins | 0.867 |
AQP6 | AQP10 | ENSP00000477688 | ENSP00000318355 | Aquaporin-6; Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism; Aquaporins | Aquaporin-10; Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol; Belongs to the MIP/aquaporin (TC 1.A.8) family | 0.906 |
AQP6 | AQP11 | ENSP00000477688 | ENSP00000318770 | Aquaporin-6; Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism; Aquaporins | Aquaporin-11; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes | 0.844 |
AQP6 | AQP12A | ENSP00000477688 | ENSP00000405899 | Aquaporin-6; Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism; Aquaporins | Aquaporin-12A; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes; Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily | 0.867 |
AQP6 | CLDN19 | ENSP00000477688 | ENSP00000296387 | Aquaporin-6; Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism; Aquaporins | Claudin-19; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins | 0.443 |
AQP6 | MTF2 | ENSP00000477688 | ENSP00000359321 | Aquaporin-6; Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism; Aquaporins | Metal-response element-binding transcription factor 2; Polycomb group (PcG) that specifically binds histone H3 trimethylated at ’Lys-36’ (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated [...] | 0.656 |
AQP6 | PVRL3 | ENSP00000477688 | ENSP00000418070 | Aquaporin-6; Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism; Aquaporins | Nectin-3; Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis- mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morpholo [...] | 0.645 |
AQP6 | RHAG | ENSP00000477688 | ENSP00000360217 | Aquaporin-6; Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism; Aquaporins | Ammonium transporter Rh type A; Associated with rhesus blood group antigen expression. May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. Involved in ammonia transport across the erythrocyte membrane. Seems to act in monovalent cation transport; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily | 0.514 |
AQP6 | RHBG | ENSP00000477688 | ENSP00000441197 | Aquaporin-6; Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism; Aquaporins | Ammonium transporter Rh type B; Functions as a specific ammonium transporter; Solute carriers | 0.520 |
AQP6 | RHCG | ENSP00000477688 | ENSP00000268122 | Aquaporin-6; Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism; Aquaporins | Ammonium transporter Rh type C; Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion; Solute carriers | 0.491 |
AQP6 | STUB1 | ENSP00000477688 | ENSP00000219548 | Aquaporin-6; Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism; Aquaporins | E3 ubiquitin-protein ligase CHIP; E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates- ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Me [...] | 0.488 |
CLDN19 | AQP6 | ENSP00000296387 | ENSP00000477688 | Claudin-19; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins | Aquaporin-6; Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism; Aquaporins | 0.443 |
MTF2 | AQP6 | ENSP00000359321 | ENSP00000477688 | Metal-response element-binding transcription factor 2; Polycomb group (PcG) that specifically binds histone H3 trimethylated at ’Lys-36’ (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated [...] | Aquaporin-6; Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism; Aquaporins | 0.656 |
MTF2 | PVRL3 | ENSP00000359321 | ENSP00000418070 | Metal-response element-binding transcription factor 2; Polycomb group (PcG) that specifically binds histone H3 trimethylated at ’Lys-36’ (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated [...] | Nectin-3; Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis- mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morpholo [...] | 0.564 |