DGKK protein (human) - STRING database

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DGKK

Diacylglycerol kinase kappa; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA) (1271 aa)

Predicted Functional Partners:

PLCB4

0.708

PLCE1

0.695

CDS2

0.695

CDS1

0.695

PLCG2

0.683

PLCG1

0.683

PLCB3

0.662

PLCB1

0.662

PLCB2

0.662

CEPT1

0.662

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDS1	CDS2	ENSP00000295887	ENSP00000419879	Phosphatidate cytidylyltransferase 1; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells	Phosphatidate cytidylyltransferase 2; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin	0.806
CDS1	CEPT1	ENSP00000295887	ENSP00000441980	Phosphatidate cytidylyltransferase 1; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells	Choline/ethanolaminephosphotransferase 1; Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity; Belongs to the CDP-alcohol phosphatidyltransferase class-I family	0.601
CDS1	DGKK	ENSP00000295887	ENSP00000477515	Phosphatidate cytidylyltransferase 1; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells	Diacylglycerol kinase kappa; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA)	0.695
CDS2	CDS1	ENSP00000419879	ENSP00000295887	Phosphatidate cytidylyltransferase 2; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin	Phosphatidate cytidylyltransferase 1; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells	0.806
CDS2	CEPT1	ENSP00000419879	ENSP00000441980	Phosphatidate cytidylyltransferase 2; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin	Choline/ethanolaminephosphotransferase 1; Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity; Belongs to the CDP-alcohol phosphatidyltransferase class-I family	0.536
CDS2	DGKK	ENSP00000419879	ENSP00000477515	Phosphatidate cytidylyltransferase 2; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin	Diacylglycerol kinase kappa; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA)	0.695
CEPT1	CDS1	ENSP00000441980	ENSP00000295887	Choline/ethanolaminephosphotransferase 1; Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity; Belongs to the CDP-alcohol phosphatidyltransferase class-I family	Phosphatidate cytidylyltransferase 1; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells	0.601
CEPT1	CDS2	ENSP00000441980	ENSP00000419879	Choline/ethanolaminephosphotransferase 1; Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity; Belongs to the CDP-alcohol phosphatidyltransferase class-I family	Phosphatidate cytidylyltransferase 2; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin	0.536
CEPT1	DGKK	ENSP00000441980	ENSP00000477515	Choline/ethanolaminephosphotransferase 1; Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity; Belongs to the CDP-alcohol phosphatidyltransferase class-I family	Diacylglycerol kinase kappa; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA)	0.662
DGKK	CDS1	ENSP00000477515	ENSP00000295887	Diacylglycerol kinase kappa; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA)	Phosphatidate cytidylyltransferase 1; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells	0.695
DGKK	CDS2	ENSP00000477515	ENSP00000419879	Diacylglycerol kinase kappa; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA)	Phosphatidate cytidylyltransferase 2; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin	0.695
DGKK	CEPT1	ENSP00000477515	ENSP00000441980	Diacylglycerol kinase kappa; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA)	Choline/ethanolaminephosphotransferase 1; Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity; Belongs to the CDP-alcohol phosphatidyltransferase class-I family	0.662
DGKK	PLCB1	ENSP00000477515	ENSP00000338185	Diacylglycerol kinase kappa; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA)	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes; C2 domain containing phospholipases	0.662
DGKK	PLCB2	ENSP00000477515	ENSP00000260402	Diacylglycerol kinase kappa; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA)	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes; C2 domain containing phospholipases	0.662
DGKK	PLCB3	ENSP00000477515	ENSP00000443631	Diacylglycerol kinase kappa; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA)	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes; C2 domain containing phospholipases	0.662
DGKK	PLCB4	ENSP00000477515	ENSP00000367762	Diacylglycerol kinase kappa; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA)	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction; C2 domain containing phospholipases	0.708
DGKK	PLCE1	ENSP00000477515	ENSP00000360431	Diacylglycerol kinase kappa; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA)	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine- exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation; C2 domain containing phospholipases	0.695
DGKK	PLCG1	ENSP00000477515	ENSP00000244007	Diacylglycerol kinase kappa; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA)	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration; C2 domain containing phospholipases	0.683
DGKK	PLCG2	ENSP00000477515	ENSP00000482457	Diacylglycerol kinase kappa; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA)	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling; C2 domain containing phospholipases	0.683
PLCB1	DGKK	ENSP00000338185	ENSP00000477515	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes; C2 domain containing phospholipases	Diacylglycerol kinase kappa; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA)	0.662

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