| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C14orf169 | HSPBAP1 | ENSP00000477507 | ENSP00000302562 | Ribosomal oxygenase 1; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates ’Lys-4’ (H3K4me) and ’Lys-36’ (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ (H3K4me3) and monomethylated H3 ’Lys-4’ (H3K4me1) residues, while it has weaker activity for dimethylated H3 ’Lys-36’ (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on ’His-216’. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX [...] | HSPB1-associated protein 1; May play a role in cellular stress response | 0.805 |
| C14orf169 | JMJD4 | ENSP00000477507 | ENSP00000355720 | Ribosomal oxygenase 1; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates ’Lys-4’ (H3K4me) and ’Lys-36’ (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ (H3K4me3) and monomethylated H3 ’Lys-4’ (H3K4me1) residues, while it has weaker activity for dimethylated H3 ’Lys-36’ (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on ’His-216’. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX [...] | JmjC domain-containing protein 4; Jumonji domain containing 4 | 0.809 |
| C14orf169 | JMJD7 | ENSP00000477507 | ENSP00000380467 | Ribosomal oxygenase 1; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates ’Lys-4’ (H3K4me) and ’Lys-36’ (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ (H3K4me3) and monomethylated H3 ’Lys-4’ (H3K4me1) residues, while it has weaker activity for dimethylated H3 ’Lys-36’ (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on ’His-216’. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX [...] | JmjC domain-containing protein 7; Jumonji domain containing 7 | 0.693 |
| C14orf169 | KDM2B | ENSP00000477507 | ENSP00000366271 | Ribosomal oxygenase 1; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates ’Lys-4’ (H3K4me) and ’Lys-36’ (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ (H3K4me3) and monomethylated H3 ’Lys-4’ (H3K4me1) residues, while it has weaker activity for dimethylated H3 ’Lys-36’ (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on ’His-216’. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX [...] | Lysine-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin lig [...] | 0.661 |
| C14orf169 | KDM8 | ENSP00000477507 | ENSP00000398410 | Ribosomal oxygenase 1; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates ’Lys-4’ (H3K4me) and ’Lys-36’ (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ (H3K4me3) and monomethylated H3 ’Lys-4’ (H3K4me1) residues, while it has weaker activity for dimethylated H3 ’Lys-36’ (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on ’His-216’. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX [...] | JmjC domain-containing protein 5; Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated ’Lys-36’ (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation. In a complex with coregulator RCCD1, is also able to demethylate trimethylated ’Lys-36’ (H3K36me3) of histone H3. Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions [...] | 0.798 |
| C14orf169 | OGFOD2 | ENSP00000477507 | ENSP00000380544 | Ribosomal oxygenase 1; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates ’Lys-4’ (H3K4me) and ’Lys-36’ (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ (H3K4me3) and monomethylated H3 ’Lys-4’ (H3K4me1) residues, while it has weaker activity for dimethylated H3 ’Lys-36’ (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on ’His-216’. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX [...] | 2-oxoglutarate and iron dependent oxygenase domain containing 2 | 0.698 |
| C14orf169 | PHF19 | ENSP00000477507 | ENSP00000483946 | Ribosomal oxygenase 1; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates ’Lys-4’ (H3K4me) and ’Lys-36’ (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ (H3K4me3) and monomethylated H3 ’Lys-4’ (H3K4me1) residues, while it has weaker activity for dimethylated H3 ’Lys-36’ (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on ’His-216’. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX [...] | PHD finger protein 19; Polycomb group (PcG) that specifically binds histone H3 trimethylated at ’Lys-36’ (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells- acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem c [...] | 0.783 |
| C14orf169 | RPL8 | ENSP00000477507 | ENSP00000262584 | Ribosomal oxygenase 1; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates ’Lys-4’ (H3K4me) and ’Lys-36’ (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ (H3K4me3) and monomethylated H3 ’Lys-4’ (H3K4me1) residues, while it has weaker activity for dimethylated H3 ’Lys-36’ (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on ’His-216’. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX [...] | 60S ribosomal protein L8; Component of the large ribosomal subunit | 0.969 |
| C14orf169 | SP7 | ENSP00000477507 | ENSP00000443827 | Ribosomal oxygenase 1; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates ’Lys-4’ (H3K4me) and ’Lys-36’ (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ (H3K4me3) and monomethylated H3 ’Lys-4’ (H3K4me1) residues, while it has weaker activity for dimethylated H3 ’Lys-36’ (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on ’His-216’. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX [...] | Transcription factor Sp7; Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity) | 0.784 |
| C14orf169 | TYW5 | ENSP00000477507 | ENSP00000346627 | Ribosomal oxygenase 1; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates ’Lys-4’ (H3K4me) and ’Lys-36’ (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ (H3K4me3) and monomethylated H3 ’Lys-4’ (H3K4me1) residues, while it has weaker activity for dimethylated H3 ’Lys-36’ (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on ’His-216’. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX [...] | tRNA wybutosine-synthesizing protein 5; tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3’-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes; Belongs to the TYW5 family | 0.751 |
| HSPBAP1 | C14orf169 | ENSP00000302562 | ENSP00000477507 | HSPB1-associated protein 1; May play a role in cellular stress response | Ribosomal oxygenase 1; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates ’Lys-4’ (H3K4me) and ’Lys-36’ (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ (H3K4me3) and monomethylated H3 ’Lys-4’ (H3K4me1) residues, while it has weaker activity for dimethylated H3 ’Lys-36’ (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on ’His-216’. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX [...] | 0.805 |
| HSPBAP1 | JMJD4 | ENSP00000302562 | ENSP00000355720 | HSPB1-associated protein 1; May play a role in cellular stress response | JmjC domain-containing protein 4; Jumonji domain containing 4 | 0.805 |
| HSPBAP1 | OGFOD2 | ENSP00000302562 | ENSP00000380544 | HSPB1-associated protein 1; May play a role in cellular stress response | 2-oxoglutarate and iron dependent oxygenase domain containing 2 | 0.743 |
| JMJD4 | C14orf169 | ENSP00000355720 | ENSP00000477507 | JmjC domain-containing protein 4; Jumonji domain containing 4 | Ribosomal oxygenase 1; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates ’Lys-4’ (H3K4me) and ’Lys-36’ (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ (H3K4me3) and monomethylated H3 ’Lys-4’ (H3K4me1) residues, while it has weaker activity for dimethylated H3 ’Lys-36’ (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on ’His-216’. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX [...] | 0.809 |
| JMJD4 | HSPBAP1 | ENSP00000355720 | ENSP00000302562 | JmjC domain-containing protein 4; Jumonji domain containing 4 | HSPB1-associated protein 1; May play a role in cellular stress response | 0.805 |
| JMJD4 | JMJD7 | ENSP00000355720 | ENSP00000380467 | JmjC domain-containing protein 4; Jumonji domain containing 4 | JmjC domain-containing protein 7; Jumonji domain containing 7 | 0.784 |
| JMJD4 | KDM2B | ENSP00000355720 | ENSP00000366271 | JmjC domain-containing protein 4; Jumonji domain containing 4 | Lysine-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin lig [...] | 0.499 |
| JMJD4 | KDM8 | ENSP00000355720 | ENSP00000398410 | JmjC domain-containing protein 4; Jumonji domain containing 4 | JmjC domain-containing protein 5; Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated ’Lys-36’ (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation. In a complex with coregulator RCCD1, is also able to demethylate trimethylated ’Lys-36’ (H3K36me3) of histone H3. Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions [...] | 0.406 |
| JMJD4 | OGFOD2 | ENSP00000355720 | ENSP00000380544 | JmjC domain-containing protein 4; Jumonji domain containing 4 | 2-oxoglutarate and iron dependent oxygenase domain containing 2 | 0.455 |
| JMJD4 | RPL8 | ENSP00000355720 | ENSP00000262584 | JmjC domain-containing protein 4; Jumonji domain containing 4 | 60S ribosomal protein L8; Component of the large ribosomal subunit | 0.477 |
